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| 1 | Derivatization in Liquid Chromatography/Mass Spectrometric Analysis of Neurosteroids显示文摘Liquid chromatography/mass spectrometry (LC/MS) is now considered to be the most promising analytical method for the determination of biological substances, especially nonvolatile or highly polar substances However, some compounds do not show enough sensitivity in LC/MS and soft ionization methods commonly used in LC/MS, such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), sometimes do not give satisfactory structural information This report presents an overview of the derivatization methods in the LC/MS analysis of neurosteroids or neuroactive neurosteroids, which are synthesized and accumulated in the nervous system The derivatization of pregnenolone 3 sulfate, one of these steroids, with 4 ( N,N dimethylaminosulfonyl) 7 hydrazino 2,1,3 benzoxadiazole gave a satisfactory sensitivity during the quantitative analysis using LC/ESI MS The obtained results are much lower than those previously obtained using gas chromatography/mass spectrometry or radioimmunoassay On the other hand, the derivatization to acetate was useful for the treatment of labile catechol estrogens in rat brains and gave enough structural information in LC/APCI MS, which confirmed the existence of catechol estrogens in mammalian | Kuniko MITAMURA, Kazutake SHIMADA (Faculty of Pharmaceutical Sciences, Kanazawa University 13 1, Takara machi, Kanazawa 920 0934, Japan) | 2001 | 色谱2001，19，6： | 5 |
| 2 | Safety and efficacy of radiofrequency thermal ablation in advanced liver tumors显示文摘 | Bowles BJ Machi J Limm WML | 2001 | Arch Surg2001，136，： | 1 |
| 3 | Long-term follow-up outcomeofpa- tients undergoing radiofrequency ablation founresectablehepatocel- lular carcinoma显示文摘 | Machi J Bueno RS Wong LL | 2012 | World J Surg2012，29，11： | 1 |
| 4 | Solitaire FR thrombectomy system: immediate results in 56 consecutive acute ischemic stroke patients显示文摘 | Machi P Costalat V Lobotesis K | 2012 | J Neurointery Surg2012，4，： | 1 |
| 5 | Intraoperative ultrasound显示文摘 | Junji Machi Andrew J Oishi Nancy L Furumoto Robert H Oishi | 2004 | Surgical Clinics of North America2004，，4： | 1 |
| 6 | Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein显示文摘 | Yasuhiro Itsui Naoya Sakamoto Sei Kakinuma Mina Nakagawa Yuko Sekine‐Osajima Megumi Tasaka‐Fujita Yuki Nishimura‐Sakurai Gouki Suda Yuko Karakama Kako Mishima Machi Yamamoto Takako Watanabe Mayumi Ueyama Yusuke Funaoka Seishin Azuma Mamoru Watanabe | 2009 | Hepatology2009，，6： | 1 |
| 7 | SonographicaUy guided radiofrequency thermal ablation for unresectable recurrent tumors in the retroperitoneum and the pelvis显示文摘 | Machi J oishi A J Furumoto NL | 2003 | J Ultrasound Med2003，22，5： | 1 |
| 8 | Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphophate显示文摘 | Machi L Christaens L Brabant S | 2002 | Thromb Res2002，107，12： | 1 |
| 9 | Operative ultrasound in general surgery显示文摘 | Machi J Sigel B | 1996 | Am J Surg1996，172，： | 1 |
| 10 | In vitro investgation of lymph node metasis of colorectal cancer using ultrasonic spectral parameters显示文摘 | T Machi J Feleppa EJ | 1998 | Ultrasound Med Boil1998，24，： | 1 |
| 11 | bcl-2/bax ratio as a predictive marker for the rapeutic response to radiotherapy in patients with prostate cancer显示文摘 | Machy TJ Borkowski A Amin | 1998 | Urol1998，56，2： | 1 |
| 12 | Ultrasound -guided radiofrequency thermal ablation of liver tumors : percutaneous, laparoscopic, and open surgical approaches 显示文摘 | Machi J Uchida S Sumida K | 2001 | J Gastrointest Surg2001，10，5： | 1 |
| 13 | Operative ultrasonography during hepatobiliary and pancreatic surgery显示文摘 | Machi J Sigel BZ aren HA etal | 1993 | World J Surg1993，17，5： | 1 |
| 14 | Copper sheath MgB2 Wires fabricated by an in situ PIT method 显示文摘 | Shimura S Machi T Murakami M | 2004 | Physica C2004，，11： | 1 |
| 15 | New trends of radiation processing application显示文摘 | Machi A U Sueo T I | | 0，，： | 1 |
| 16 | Criteria for using imaging ultrasound during brain and spinal cord surgery显示文摘 | Machi J Sigel B Jafar J J | 1984 | J Ultra- sound Med1984，3，4： | 1 |
| 17 | Intraoperative and laparoscopic ultrasound显示文摘 | Machi J | 1999 | Surg Oncol Clin N Am1999，8，1： | 1 |
| 18 | Intraoperative ultrasound 显示文摘 | Machi J Oishi AJ Furumoto NL | 2004 | Surg Clin North Am2004，84，4： | 1 |
| 19 | Neuroform stent-assisted coiling of unruptured intracranial aneurysms:short-and midterm results from a single-center experience with 68 patients显示文摘 | Maldonado IL Machi P Costalat V | 2011 | Am J Neuroradiol2011，32，： | 1 |
| 20 | 无机填料对聚氨酯阻尼材料性能影响的研究进展[J]显示文摘 | GouChuanping(苟川平) ChenErfan(陈尔凡) MaChi(马驰) | 2012 | 辽宁化工2012，41，5： | 1 |
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