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| 1 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 2 | 烧结工艺使用气体燃料喷入技术减少CO_2排放显示文摘JFE钢铁公司开发了在烧结矿表面喷入含氢的气体燃料技术,可不增加焦粉配比,提高烧结矿质量。使用该技术,含氢气体可部分替代焦粉,使1200~1400℃的燃烧层变宽成为可能。通过X射线对多孔状的烧结饼进行CT检查与烧结锅试验,从理论到实践都证明了喷入燃料气体技术的使用效果。保持1200~1400℃的温度带,为生产高强度、高还原性的烧结矿至关重要,它能使合适的温度带变宽、液相率增加、提高1~5mm孔隙间的熔合并提升烧结矿强度。大于5mm的孔隙的烧结矿数量增多提高了料层的透气性,低温烧结工艺也抑制了铁矿石的自身熔化。而在未熔化的铁矿石中,小于1μm的微孔隙的存在也使烧结矿的还原性提高,从而改善烧结饼的孔隙结构,提高烧结矿质量。2009年1月,京浜1号烧结机应用了该技术,到目前为止工况稳定。结果,烧结工序的能源利用率大幅提升,减排CO2约6万t/a。 | Nobuyuki Oyama Yuji Iwami Satoshi Machida Takahide Higuchi Tetsuya Yamamoto Yushinori Watanabe Michitaka Sato Kanji Takeda Masakata Shimizu Koki Nishioka 何海良 | 2013 | 世界钢铁2013，，1： | 11 |
| 3 | 抗甲氧西林金葡球菌耐药性的研究显示文摘抗甲氧西林金葡球菌(MRSA)感染发病率有逐年增加趋势。为了解MRSa耐药特点及合理选用抗菌药物,本文测定了18种抗菌药物对临床分离金葡球菌(SA)的最低抑菌浓度(MIC)、受试菌的β-内酰胺酶及凝固酶分型。结果表明MRSA占临床分离SA的50.7%,其中产β-内酰胺酶菌株占85.1%,MRSA凝固酶均为Ⅱ型。MRSA对多数β-内酰胺类及某些氨基糖苷类抗生素呈多重耐药性。万古霉素、Arbikacin对MRSA显示最强的抗菌活性;二甲胺四环素、丁胺卡那霉素、Tosufloxacin、Imipenam亦显示较强抗菌活性,提示上述抗菌药物可用于MRSA所致严重感染。 | 王睿 Nishioka K Tanneo Y | 1992 | 中国抗生素杂志1992，17，6： | 7 |
| 4 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 5 | STUDIES ON TANNIN CONSTITUENTS OF ROOT FROM Potentilla viscosa显示文摘Potentilla viscosa J. Don is widely distributed over the districts of Baicheng and Yanbian in Jilin Province. The root of P. viscosa can be used for the treatment of hepatitis. In our chemical investigation of tannin, we isolated seven compounds. Now we will describe them as follows. | 张本 黄青 张洪岩 李超生 吕琳 GEN-ICHIRO NONAKA ITSUO NISHIOKA | 1990 | Chinese Science Bulletin1990，35，3： | 3 |
| 6 | Role of diffusion-weighted imaging in evaluating therapeutic efficacyafter transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘 | Kei Kubota Tomoaki Yamanishi Satoshi Itoh Yoriko Murata Kana Miyatake Hiroaki Yasunami Kazuo Morio Norihiko Hamada Akihito Nishioka Yasuhiro Ogawa | 2010 | Oncology Reports2010，，3： | 3 |
| 7 | 经皮冠状动脉成形术中的冠状动脉破裂原因分析显示文摘目的:探讨冠状动脉成形术中冠状动脉破裂的可能原因。方法:对所有介入治疗前的靶病变行定性和定量造影分析,并选择在发生冠状动脉破裂前最近一次的血管内超声(IVUS)图像进行分析。结果:在5个心脏介入中心总共1 506例经皮冠状动脉成形术(PCI)患者中,发生冠状动脉破裂15例(1.0%),其中6例与操作导丝相关,1例与单纯球囊扩张相关,8例与支架植入相关。6例与导丝相关的破裂均由亲水涂层或中等硬度导丝所致,靶病变包括3例闭塞、4例偏心和3例分叉病变。与球囊或支架相关冠状动脉破裂包括6例偏心、6例中等至严重钙化病变。有血管内超声分析的5例,其病变偏心率均小于0.4,钙化弓在42~109度。除了单纯球囊破裂病例,在所有支架植入导致的破裂,球囊/管腔比值均超过1.3。所有与导丝相关冠状动脉破裂属于EllisⅡ级,与球囊或支架相关的2例属Ⅱ级,7例属Ⅲ级。结论:导丝相关的冠状动脉破裂常发生在采用亲水涂层或中等硬度导丝对偏心、分叉或闭塞病变进行操作;球囊或支架相关冠状动脉破裂经常与球囊尺寸过大或压力过大有关,常发生在偏心和伴钙化的病变处。 | 邱朝晖 Kataoka Toru 郭新贵 Kobayashi Yoshiki Nishioka Hiroki 张煜 Sakamoto Kazuo Yoshi mura Takayoshi Shi mada Kenei Yoshikawa Junichi | 2010 | 中国临床医学2010，17，4： | 3 |
| 8 | The Cost Effectiveness of Radiofrequency Ablation for Barrett’s Esophagus显示文摘 | Chin Hur Sung Eun Choi Joel H. Rubenstein Chung Yin Kong Norman S. Nishioka Dawn T. Provenzale John M. Inadomi | 2012 | Gastroenterology2012，，3： | 2 |
| 9 | Hepatitis B virus infection in Indonesia显示文摘Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 10 | 在有 vasospastic 咽峡炎的病人的冠的 microvascular 功能的评估显示文摘 AIM: To investigate endothelium-dependent and independent coronary microvascular functions in patients with vasospastic angina (VSA). METHODS: Thirty-six patients with VSA (30 men and 6 women; mean age, 58 years) were enrolled in this study. VSA was defined as ≥ 90% narrowing of the epicardial coronary arteries on angiography performed during a spasm provocation test, presence of chest pain, and/or ST-segment deviation on an electrocardiogram (ECG). Patients (n = 36) with negative spasm provocation test results and those matched for age and sex were enrolled as a control group (nonVSA group). Low-dose acetylcholine (ACh; 3 μg/min) was infused into the left coronary ostium for 2 min during the spasm provocation test. Following the spasm provocation test, nitroglycerin (0.2 mg) was administered intracoronally. Coronary blood flow (was calculated from quantitativeangiography and Doppler flow velocity measurements, and the coronary flow reserve was calculated as the ratio of coronary flow velocity after injection of adenosine triphosphate (20 μg) to the baseline value. Changes in the coronary artery diameter in response to ACh and nitroglycerin infusion were expressed as percentage changes from baseline measurements. RESULTS: Body mass index was significantly lower in the VSA group than in the nonVSA group. The fre- quency of conventional coronary risk factors and the rate of statin use were similar between the 2 groups. The left ventricular ejection fraction as evaluated by echocardiography was similar between the 2 groups. The duration of angina was 9 ± 2 mo. The results of blood chemistry analysis were similar between the 2 groups. Low-dose ACh did not cause coronary spasms. The change in coronary artery diameter in response to ACh was lower in the VSA group (-1.4% ± 9.3%) than in the nonVSA group (3.1% ± 6.5%, P < 0.05), whereas nitroglycerin-induced coronary artery dilatation and coronary blood flow increase in response to ACh or coronary flow reserve did not differ significantly between the 2 groups. CONCLUSION: These findings suggest that microvascular coronary function may be preserved despite endothelial dysfunction of the epicardial coronary arteries in patients with VSA. | Hiroki Teragawa Naoya Mitsuba Ken Ishibashi Kenji Nishioka Satoshi Kurisu Yasuki Kihara | 2013 | World Journal of Cardiology2013，5，1： | 2 |
| 11 | Impaired coronary microvascular endothelial function in men with metabolic syndrome显示文摘AIM: To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS: Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%). The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION: Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study. | Hiroki Teragawa Naoya Mitsuba Kenji Nishioka Kentaro Ueda Shingo Kono Yukihito Higashi Kazuaki Chayama Yasuki Kihara | 2010 | World Journal of Cardiology2010，2，7： | 2 |
| 12 | Plasma depletions lasting into daytime during the recovery phase of a geomagnetic storm in May 2017:Analysis and simulation of GPS total electron content observations显示文摘This paper reports that plasma density depletions appearing at middle latitudes near sunrise survived until afternoon on 29 May 2017 during the recovery phase of a geomagnetic storm.By analyzing GPS data collected in Japan,we investigate temporal variations in the horizontal two-dimensional distribution of total electron content(TEC)during the geomagnetic storm.The SYM-H index reached-142 n T around 08 UT on 28 May 2017.TEC depletions extending up to approximately 38°N along the meridional direction appeared over Japan around 05 LT(LT=UT+9 hours)on 29 May 2017,when TEC rapidly increased at sunrise due to the solar extreme ultraviolet(EUV)radiation.The TEC depletions appeared sequentially over Japan for approximately 8 hours in sunlit conditions.At 06 LT on 29 May,when the plasma depletions first appeared over Japan,the background TEC was enhanced to approximately 17 TECU,and then decreased to approximately 80%of the TEC typical of magnetically quiet conditions.We conclude that this temporal variation of background plasma density in the ionosphere was responsible for the persistence of these plasma depletions for so long in daytime.By using the Naval Research Laboratory:Sami2 is Another Model of the Ionosphere(SAMI2),we have evaluated how plasma production and ambipolar diffusion along the magnetic field may affect the rate of plasma depletion disappearance.Simulation shows that the plasma density increases at the time of plasma depletion appearance;subsequent decreases in the plasma density appear to be responsible for the long-lasting persistence of plasma depletions during daytime.The plasma density depletion in the top side ionosphere is not filled by the plasma generated by the solar EUV productions because plasma production occurs mainly at the bottom side of the ionosphere. | Yuichi Otsuka Atsuki Shinbori Takuya Sori Takuya Tsugawa Michi Nishioka Joseph D.Huba | 2021 | Earth and Planetary Physics2021，5，5： | 2 |
| 13 | A Central Pancreatectomy for Benign or Low-Grade Malignant Neoplasms显示文摘 | Seiko Hirono Masaji Tani Manabu Kawai Shinomi Ina Ryohei Nishioka Motoki Miyazawa Atsushi Shimizu Kazuhisa Uchiyama Hiroki Yamaue | 2009 | Journal of Gastrointestinal Surgery2009，，9： | 2 |
| 14 | Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction显示文摘 | Satoshi Kurisu Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Kenji Nishioka Takashi Umemura Suji Nakamura Masashi Yoshida Hikaru Sato | 2003 | Journal of the American College of Cardiology2003，，： | 2 |
| 15 | L-精氨酸能改善MELAS卒中样发作症状 | Koga Y. Akita Y. Nishioka J. 李一明 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，7： | 2 |
| 16 | Novel serine/threonine kinase 11 gene mutations in PeutzJeghers syndrome patients and endoscopic management显示文摘AIM:To explore mutations in serine/threonine kinase 11(STK11) gene in Peutz-Jeghers syndrome(PJS) with gastrointestinal(GI) hamartomatous polyps.METHODS:Six Japanese PJS patients in 3 families were enrolled in this study.Each of the cases had hamartomatous polyposis in the gastrointestinal tract,including the small intestine,along with mucocutaneous hyperpigmentation.Narrow-band imaging(NBI)-magnification endoscopy was employed to detect microvascular and microsurface irregularities in the GI lesions.NBI magnification findings could be classified into three groups(type A,type B,or type C).Endoscopic polypectomy was performed using double-balloon enteroscopy or colonoscopy.Genomic DNA was extracted from a whole blood sample from each subject.All of the coding exons of STK11 gene,its boundary regions,and the promoter region containing the polymorphic regions were amplified by polymerase chain reaction,and direct sequencing was performed to assess the germline mutations.RESULTS:NBI-magnification endoscopic observation could detect the abnormalities in microvessels and microsurface structures of GI polyps.Overall,we found 5 cases of type A and one case without the examination for the gastric polyps,while there were 4 cases of type B and 2 case of type A for the colorectal polyps.Seventy-nine small-bowel and 115 colorectal polyps over 27 sessions for each were resected endoscopically without significant complications.The only delayed complication included the occurrence of bleeding in a case,and this was successfully managed with hemoclips.Resected polyps contained no malignant components.Based on mutation analysis,all 3 cases in Family I exhibited the +658C>T nonsense mutation in exon 5,which resulted in the production of a truncated protein(Q220X).In Family II,a case had-252C>A and-193C>A in the promoter region.In Family III,a case was found to have the +1062C>G(F342L) mutation in exon 8.CONCLUSION:We found two novel mutations of STK11 in association with PJS.Endoscopic polypectomy of GI polyps in PJS patients appears to be useful to prevent emergency laparotomies and reduce the cancer risk. | Hiroyuki Yajima Hajime Isomoto Hiroaki Nishioka Naoyuki Yamaguchi Ken Ohnita Tatsuki Ichikawa Fuminao Takeshima Saburo Shikuwa Masahiro Ito Kazuhiko Nakao Kazuhiro Tsukamoto Shigeru Kohno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 17 | Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury显示文摘 | Masashi Tamaoki Kyoko Imanaka-Yoshida Kazuto Yokoyama Tomohiro Nishioka Hiroyasu Inada Michiaki Hiroe Teruyo Sakakura Toshimichi Yoshida | 2005 | The American Journal of Pathology2005，，： | 2 |
| 18 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 19 | Premature p34cdc2 activation required for apoptosis显示文摘 | Shi L Nishioka W K Th'ng J | 1994 | Science1994，263，5150： | 1 |
| 20 | Novel dry-desulfurization process using Ca(OH)2/fly ash sorbent in a circulating fluidized bed 显示文摘 | Matsushima N Li Y Nishioka M | 2004 | Eviron Sci Technol2004，38，24： | 1 |
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