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| 1 | Genome engineering using the CRISPR/Cas system显示文摘Recently, an epoch-making genome engineering technology using clustered regularly at interspaced short palindromic repeats(CRISPR) and CRISPR associated(Cas) nucleases, was developed. Previous technologies for genome manipulation require the time-consuming design and construction of genome-engineered nucleases for each target and have, therefore, not been widely used in mouse research where standard techniques based on homologous recombination are commonly used. The CRISPR/Cas system only requires the design of sequences complementary to a target locus, making this technology fast and straightforward. In addition, CRISPR/Cas can be used to generate mice carrying mutations in multiple genes in a single step, an achievement not possible using other methods. Here, we review the uses of this technology in genetic analysis and manipulation, including achievements made possible to date and the prospects for future therapeutic applications. | Takuro Horii Izuho Hatada | 2014 | World Journal of Medical Genetics2014，4，3： | 9 |
| 2 | Preparation of hydrophobic diamond like carbon films by plasma source ion Implantation显示文摘 | Hatada R Baba K | 1999 | Nuclear Instrunentsand Methods1999，148，14： | 2 |
| 3 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 4 | Thermostabilization by replacement of specific residues with lysine in a Bacillus alkaline cellulase:building a structural model and implications of newly formed double intrahelical salt bridges显示文摘 | Hakamada Y Hatada Y | 2001 | Protein Eng2001，14，： | 1 |
| 5 | Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in HepG2 cells显示文摘 | Hatada EN Mcclain DA Potter E | 1989 | J Biol Chem1989，264，12： | 1 |
| 6 | Mutant influenza A virus with a defective NS 1 protein cannot block the activation of PKR in infected cells显示文摘 | Hatada E Fukuda R Saito S | 1999 | J Virol1999，73，5： | 1 |
| 7 | Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles显示文摘 | Kusari J Takata Y Hatada E | 1991 | J Biol Chem1991，266，8： | 1 |
| 8 | Insulin resistance and diabetes due to different mutations in the tyrosin kinase domain of both insulin receptor gene alleles显示文摘 | Kusari J Takata Y Hatada E | 1991 | J Biol Chem1991，266，8： | 1 |
| 9 | Catheter-based prostacyclin synthase gene transfer prevents instent stenosis in rabbit atheromatous arteries 显示文摘 | NUMAGUCHI Y OKUMUTA K HATADA M | 2004 | Cardiovasc Res2004，61，1： | 1 |
| 10 | Attenuation of apoptosis underlied B lymphocyte stimulator enhancement of humoral immune responses显示文摘 | Do R K Hatada E Lee H | 2000 | J Exp Med2000，192，： | 1 |
| 11 | Structure and Properties of NbN and TaN Films Prepared by Ion Beam Assisted Deposi- tion显示文摘 | Baba K Hatada R Udoh K | 1997 | Nuclear Instruments and Methods in Physics Re- search1997，，： | 1 |
| 12 | Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response显示文摘 | Hatada E Lee H | 2000 | J Exp Med2000，192，7： | 1 |
| 13 | α-Glucosidase from a Strain of Deep-sea Geobaeillus : a Potential Enzyme for the Biosynthesis of Complex Carbohydrates显示文摘 | Vo Si Hung Yuji Hatada Saori Coda | 2005 | Appl Micro- biol Biotechnol2005，68，： | 1 |
| 14 | Genomic imprinting of p57^kip2 a cyclin- dependent kinase inhibitor, in mouse 显示文摘 | Hatada I Mukai T | 1995 | Nal Genet1995，11，2： | 1 |
| 15 | Synthesis zeolites as catalysts for the ring conversion of γ-butyrolactone into 1-substituted 2-pyrrolidinones显示文摘 | Kou Hatada Yoshio Ono | 1977 | Bull Chem Soc Jpn1977，50，10： | 1 |
| 16 | Binding of influenza A virus NS1 protein to dsRNA in vitro显示文摘 | Hatada E Fukuda R | 1992 | Gen Virol1992，73，12： | 1 |
| 17 | Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenose显示文摘 | Hatada K Ruiz M Riou L M | 2006 | J Nucl Cardiol2006，13，： | 1 |
| 18 | Dynamic load balancing among multiple fabrication lines through estimation of minimum inter-operation time 显示文摘 | Toba H Izumi H Hatada H | 2005 | IEEE Transactions on Semiconductor2005，18，1： | 1 |
| 19 | Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses显示文摘 | SOTOMARU Y KATSUZAWA Y HATADA I | 2002 | Journal of Biological Chemistry2002，277，12： | 1 |
| 20 | J Am Chem Soc显示文摘 | Okamoto Y Kawashima M Hatada K | 1984 | 106:5 3571984，106，： | 1 |
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