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| 1 | Successful laparoscopic splenectomy after living-donor liver transplantation for thrombocytopenia caused by antiviral therapy显示文摘Although interferon (IFN) based therapy for recurrent hepatitis C virus (HCV) infection after liver transplantation has been widely accepted, it induces various adverse effects such as thrombocytopenia, resulting in its interruption. Recently, concomitant splenectomy at the time of living donor liver transplantation (LDLT) has been tried to overcome this problem, but this procedure leads to several complications such as excessive intraoperative bleeding and serious infection. A 60-year-old female received LDLT using a left lobe graft from her second son for liver failure caused by hepatitis C-related cirrhosis. Six months after LDLT, she was diagnosed as recurrent HCV infection by liver biopsy. IFN monotherapy was started from 7 mo after LDLT and her platelet count decreased to less than 50 000/μL, which thus made it necessary to discontinue the treatment. We decided to attempt laparoscopic splenectomy (LS) under general anesthesia. Since intra-abdominal findings did not show any adhesion formations around the spleen, LS could be successfully performed. After LS, since her platelet count immediately increased to 225 000/μL 14 d after operation, IFN therapy was restarted and we could convert the combination therapy of IFN and ribavirin, resulting in no detectable viral marker. Inconclusion, LS can be performed safely even after LDLT, and LS after LDLT is a feasible and less invasive modality for thrombocytopenia caused by antiviral therapy. | Hiroyuki Kato Masanobu Usui Yoshinori Azumi Ichiro Ohsawa Masashi Kishiwada Hiroyuki Sakurai Masami Tabata Shuji Isaji | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 2 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 3 | Treatment of chronic pancreatitis complicated by obstruction of the common bile duct or duodenum显示文摘 | Charles F. Frey M.D. Mamoru Suzuki M.D. Shuji Isaji M.D | 1990 | World Journal of Surgery1990，，1： | 3 |
| 4 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Miho Sekimoto Tadahiro Takada Yoshifumi Kawarada Koichi Hirata Toshihiko Mayumi Masahiro Yoshida Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Shuji Isaji Masaru Koizumi Makoto Otsuki Seiki Matsuno | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，： | 2 |
| 5 | A standardized technique for safe pancreaticojejunostomy:Pair-Watch suturing technique显示文摘AIM:To prevent pancreatic leakage after pancreaticoje-junostomy,we designed a new standardized technique that we term the 'Pair-Watch suturing technique'.METHODS:Before anastomosis,we imagine the faces of a pair of watches on the jejunal hole and pancreatic duct.The first stitch was put between 9 o'clock of the pancreatic side and 3 o'clock of the jejunal side,and a total of 7 stitches were put on the posterior wall,followed by the 5 stitches on the anterior wall.Using this technique,twelve stitches can be sutured on the first layer anastomosis regardless of the caliber of the pancreatic duct.In all cases the amylase activity of the drain were measured.A postoperative pancreatic fistula was diagnosed using postoperative pancreatic fistula grading.RESULTS:From March 2007 to July 2008,29 consecutive cases underwent pancreaticojejunostomy using this technique.Pathologic examination results showed pancreatic carcinoma(n=14),intraductal papillary-mucinous neoplasm(n=10),intraductal papillary-mucinous carcinoma(n=1),carcinoma of ampulla of Vater(n=1),carcinoma of extrahepatic bile duct(n=1),metastasis of renal cell carcinoma(n=1),and duodenal carcinoma(n=1).Pancreaticojejunal anastomoses using this technique were all watertight during the surgical procedure.The mean diameter of main pancreatic duct was 3.4 mm(range 2-7 mm).Three patients were recognized as having an amylase level greater than 3 times the serum amylase level,but all of them were diagnosed as grade A postoperative pancreatic fistula grading and required no treatment.None of the cases developed complications such as hemorrhage,abdominal abscess,and pulmonary infection.There was no postoperative mortality.CONCLUSION:Our technique is less complicated than other methods and very secure,providing reliable anastomosis for any size of pancreatic duct. | Yoshinori Azumi Shuji Isaji Hiroyuki Kato Yuu Nobuoka Naohisa Kuriyama Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 2 |
| 6 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Miho Sekimoto Tadahiro Takada Yoshifumi Kawarada Koichi Hirata Toshihiko Mayumi Masahiro Yoshida Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Shuji Isaji Masaru Koizumi Makoto Otsuki Seiki Matsuno | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，1： | 2 |
| 7 | Radical operation for carcinoma of the gallbladder: present status in Japan 显示文摘 | Ogura Y Mizamoto R Isaji S | 1991 | World Surg1991，15，3： | 2 |
| 8 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 9 | Laparo- scopic spleen-preserving pancreatic tail resection for an intrapancreatic accessory spleen mimicking a nonfunctioning en- docrine tumor:Report of a case显示文摘 | Hamada T Isaji S Mizuno S | 2004 | Surgery Today2004，34，10： | 1 |
| 10 | N-glyeosylation of the beta-propeller domain of the integin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function显示文摘 | Isaji T Sato Y Zhao Y | 2006 | J Biol Chem2006，281，33： | 1 |
| 11 | Clinical features and treatment outcome of borderline resectable pancreatic head/body cancer: a multi-institutional survey by the Japanese Society of Pancreatic Surgery显示文摘 | Hiroyuki Kato Masanobu Usui Shuji Isaji Takukazu Nagakawa Keita Wada Michiaki Unno Akimasa Nakao Shuichi Miyakawa Tetsuo Ohta | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 1 |
| 12 | Liver injury in acute pancreatitis and mitigation by continuous arterial infusion of an antibiotic via the superior mesenteric artery显示文摘 | Miyahara S Isaji S | 2001 | Pancreas2001，23，2： | 1 |
| 13 | Classification of pancreaticcancer: comparison of Japanese and UICC classifications 显示文摘 | Isaji S Kawarada Y Uemoto S | 2004 | Pancreas2004，28，3： | 1 |
| 14 | Radical operations for carcinoma of the gallbladder: present status in Japan显示文摘 | Mizumoto R Isaji S | 1991 | World J Surg1991，15，： | 1 |
| 15 | Experiences and problems pre- operative anti-CD20 monoclonal antibody infusion therapy with splenectomy and plasma exchange for ABO-ineompatible living-donor liver transplantation显示文摘 | Usui M Isaji S Mizuno S | 2007 | Clin Transplant2007，21，1： | 1 |
| 16 | Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan显示文摘 | Shuji Isaji Yoshifumi Kawarada Hiroki Taoka Masami Tabata Hideo Suzuki Hajime Yokoi | 1999 | Journal of Hepato - Biliary - Pancreatic Surgery1999，，2： | 1 |
| 17 | Experiences and problems pre-operative anti-CD20 monoclonal antibody infusion therapy with splenectomy and plasma exchange for ABO-incompatible living-donor liver transplantation显示文摘 | Usui M Isaji S Mizuno S | | 0，，01： | 1 |
| 18 | Intraductal Papillary Neoplasm of Bile Duct Detected on Fluorodeoxyglucose–Positron Emission Tomography Performed for Cancer Scanning显示文摘 | Hiroyuki Inoue Syuji Isaji Yoshiyuki Takei | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 1 |
| 19 | Stented pancreaticojejunostomy ( with video) 显示文摘 | Azumi Y Isaji S | 2012 | JHepatobiliary Pancreat Sci2012，19，2： | 1 |
| 20 | Liver injury in acute pancreatitis and mitigation by continuous arterial infusion of an antibiotic via the superior mesentericartery显示文摘 | MIYAHARA S ISAJI S | 2001 | Pancreas2001，23，： | 1 |
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