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| 1 | Electrochemical synthesis of silver nanoparticles-coated gold nanoporous film electrode and its application to amperometric detection for trace Cr(VI)显示文摘A simple and rapid approach for the electrochemical synthesis of Ag nanoparticles-coated gold nanoporous film (AgGNF) on a gold substrate was reported. The solid gold electrode (SGE) was directly anodized under a high potential of 5 V, and then reduced to obtain gold nanoporous film (AuNF) by freshly prepared ascorbic acid. The Ag nanoparticles (AgNPs) were grown on the AuNF electrode by potential-step electrodeposition. The resulting AgGNF composites electrodes were characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy and cyclic voltammetry (CV). As-prepared AgGNF electrode was used as a kind of superior sensor for Cr(VI) detection, which exhibited better electrocatalytic behavior than those of AuNF and SGE under identical conditions. Such a designed AgGNF nanocomposites electrode showed outstanding sensitivity (about 0.15 nA/ppb) and favorable reproducibility for Cr(VI) detection. The dependence of reduction current on Cr(VI) concentration is linear from 2 to 370 ppb with a low detection limit of 0.65 ppb. Interferences from other heavy metals ions (Cr3+, Cu2+, Pb2+, As3+ and Hg2+) associated with Cr(VI) analysis could be effectively diminished. The present method proves to be rapid, reliable, sensitive and low-cost. | XU He ZHENG QiaoLi YANG Ping LIU JianShe XING SuJie JIN LiTong | 2011 | Science China Chemistry2011，54，6： | 9 |
| 2 | A coupled ice-ocean model for the Bohai SeaⅡ.Case study显示文摘The coupled ice- ocean model for the Bohai Sea is used for simulating the freezing, melting, and variation of ice cover and the heat bal- ance at the sea- ice, air- ice, and air- sea interfaces of the Bohai Sea during the entire winter in 1998￣1999 and 2000￣2001. The cou- pled model is forced by real time numerical weather prediction fields. The results show that the thermodynamic effects of atmosphere and ocean are very important for the evolvement of ice in the Bohai Sea, especially in the period of ice freezing and melting. Ocean heat flux plays a key role in the thermodynamic coupling. The simulation also presents the different thermodynamic features in the ice covered region and the marginal ice zone. Ice thickness, heat budget at the interface, and surface sea temperature, etc. between the two representative points are discussed. | SUJie WUHuiding ZHANGYunfei LIUQinzhen BAIShan | 2005 | Acta Oceanologica Sinica2005，24，3： | 8 |
| 3 | Experimental study on behaviors of polypropylene fibrous concrete beams显示文摘Synthetic fibers made from nylon or polypropylene have gained application when loose and woven into geo textile form although no information on the matrix’s mechanical performance is obtained so that more understanding of their structural contribution to resist cracking can be determined. This paper presents the results of an experimental investigation to determine the performance characteristics of concrete reinforced with a polypropylene structural fiber. In this investigation “Fiber mesh” brand of fibers manufactured by SL Concrete System, Tennessee, USA and marketed by M/S Millennium Building System, Inc., Ban-galore, India are used. The lengths of the fibers used were 24 mm. Fiber dosages used were 0.9, 1.8, 2.7 kg/m3. A total of three mixtures, one for each fiber dosage were made. A standard slump cone test was conducted on the fresh concrete mix with and without fibers to determine the workability of the mix. The test program included the evaluation of hardened concrete properties such as compressive, split tensile, modulus of rupture and flexural strengths. The increase in compressive strength is about 36.25%, 26.20%, and 23.75% respectively that of plain concrete. This increase in strength was directly proportional to amount of fibers present in the mix. The increase in flexural strength for Mixes I^III is about 21%, 16.6%, and 23% respectively that of plain concrete specimens. An experimental investigation was also made to study the behaviors of reinforced fibers concrete beams (with longitudinal reinforcements) under two-point loading. The deflection and crack patterns were also studied. The improvements in strength and ductility characteristics were discussed. | SUJI D. NATESAN S. C. MURUGESAN R. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，7： | 6 |
| 4 | Efficacy of Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural or Peritoneal Effusions显示文摘Background and objective Once the malignant pleural or peritoneal effusion is developed it is difficult to control.This report presents a new method for controlling the malignant effusions.Methods Forty-eight patients,29 males and 19 females with an average age of 61.2 years old,who were satisfied with the study inclusion criteria,were recruited in this study.Twenty-seven and 21 patients had a malignant pleural and peritoneal effusion,respectively.After draining most of fluids,these patients received intra-cavity infusion of rAd-p53 once per week for 4 weeks,at dose of 2×1012 viral particles(VP) diluted into 200 mL of saline solution for pleural effusions,and 4×1012 VP diluted into 500 mL of saline solution for peritoneal effusions.Results Participants were followed up for a median time of 13.6 month.A total of 11 cases,7 with pleural effusions and 4 with peritoneal effusions achieved a complete response(CR),and 20 cases(12 pleural effusions and 8 peritoneal effusions) had a partial response(PR).The overall response rate is 64.6%.Patients' quality of life,assessed by using Karnofsky performance scale(KPS) scores,was improved by an average of 26.4.The one-year of overall survival rate was 54.2% with a median survival time of 12.5 months.There were no serious side effects observed except for self-limited fever found in 79.8% of the cases.Conclusions Intra-cavity infusion of rAd-p53 is an effective and safe treatment for the patients with malignant pleural or peritoneal effusions,especially for those patients who can't tolerate the standard treatments. | Xin ZHANG Yi HU Jinliang WANG Sujie ZHANG Haitao TAO Sun JING Baishou WU | 2013 | 中国肺癌杂志2013，16，3： | 5 |
| 5 | A coupled ice-ocean model for the Bohai Sea Ⅰ. Study on model and parameter显示文摘According to the earlier international studies on the coupled iceocean model and the hydrology, meteorology, and icefeatures in the Bohai Sea, a coupled iceocean model is developed based on the National Marine EnvironmentForecast Centers (NMEFC) numerical forecasting ice model of the Bohai Sea and the Princeton ocean model (POM).In the coupled model, the transfer of momentum and heat between ocean and ice is two-way, and the change of icethickness and concentration depends on heat budget not only at the surface and bottom of ice, but also at the surfaceof open water between ices. The dynamic and thermodynamic coupling process is expatiated emphatically. Somethermodynamic parameters are discussed as well. | SUJie WUHuiding ZHANGYunfei LIUQinzhen BAIShan | 2004 | Acta Oceanologica Sinica2004，23，4： | 5 |
| 6 | Impact of sugar beet pulp and wheat bran on serum biochemical profile,inflammatory responses and gut microbiota in sows during late gestation and lactation显示文摘Background:Sows are frequently subjected to various stresses during late gestation and lactation,which trigger inflammatory response and metabolic disorders.Dietary fiber can influence animal health by modulating gut microbiota and their by-products,with the effects depending upon the source of the dietary fiber.This study aimed to evaluate the impacts of different fiber sources on body condition,serum biochemical parameters,inflammatory responses and fecal microbiota in sows from late gestation to lactation.Methods:Forty-five multiparous sows(Yorkshire×Landrace;3–6 parity)were assigned to 1 of 3 dietary treatments from d 85 of gestation to the end of lactation(d 21 post-farrowing):a control diet(CON,a corn-soybean meal diet),a sugar beet pulp diet(SBP,20%SBP during gestation and 10%SBP during lactation),and a wheat bran diet(WB,30%WB during gestation and 15%WB during lactation).Results:Compared with CON,supplementation of SBP decreased(P<0.05)lactation BW loss,reduced(P<0.05)serum concentration of total cholesterol,non-esterified fatty acids,interleukin-6 and tumor necrosis factor-α,and increased(P<0.05)fecal water content on d 110 of gestation and d 21 of lactation,while supplementation of WB reduced(P<0.05)serum concentration of total cholesterol on d 110 of gestation,increased(P<0.05)fecal water content and decreased(P<0.05)serum interleukin-6 concentration on d 110 of gestation and d 21 of lactation.In addition,sows fed SBP had lower(P<0.01)abundance of Clostridium_sensu_stricto_1 and Terrisporobacter than those fed CON,but had greater(P<0.05)abundance of Christensenellaceae_R-7_group and Ruminococcaceae_UCG-002 than those fed the other two diets on d 110 of gestation.On d 21 of lactation,supplementation of SBP decreased(P<0.05)the abundance of Firmicutes and Lactobacillus,but enriched(P<0.05)the abundance of Christensenellaceae_R-7_group,Prevotellaceae_NK3B31_group,Ruminococcaceae_UCG-002,Prevotellaceae_UCG_001 and unclassified_f__Lachnospiraceae compared with WB.Compared with CON,sows fed SBP had greater(P<0.05)fecal concentrations of acetate,butyrate and total SCFAs during gestation and lactation,while sows fed WB only had greater(P<0.05)fecal concentration of butyrate during lactation.Conclusions:Supplementation of dietary fiber during late gestation and lactation could improve sow metabolism and gut health,and SBP was more effective than WB. | Qinghui Shang Sujie Liu Hansuo Liu Shad Mahfuz Xiangshu Piao | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 7 | The Clouds That Float By显示文摘AS I walk toward the autumn of my life, I begin to realize that everything in the world seems to have moved in a cycle, like the four seasons that continue to change and renew outside my window. But I am still seated in front of my window, observing the floating clouds at the ends of the earth. Some of them float from the future, some from the past. They join at the head and the tail of the universe; it is hard to tell the dragon’s head from the dragon’s tail. Things are always like this—the beginnings and the endings are sometimes interchangeable; the things that you think have gone by, have gone far away or completely vanished will suddenly appear before you like old acquaintances. Perhaps it might be the second generation accompanied by the shadows of the first. | ZHENG MIN MAN SUJIE | 1995 | Women of China1995，，3： | 4 |
| 8 | Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation显示文摘Host interferon-stimulated gene 20(ISG20)exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling.Here,we examined the role of ISG20 during pseudorabies virus(PRV)proliferation.We found that ISG20 modulates PRV replication by enhancing IFN signaling.Further,ISG20 expression was upregulated following PRV infection and poly(I:C)treatment.Ectopic expression of ISG20 inhibited PRV proliferation in PK15 cells,whereas knockdown of ISG20 promoted PRV proliferation.In addition,ISG20 expression upregulated IFN-βexpression and enhanced IFN downstream signaling during PRV infection.Notably,PRV UL24 suppressed the transcription of ISG20,thus antagonizing its antiviral effect.Further domain mapping analysis showed that the N terminus(amino acids 1-90)of UL24 was responsible for the inhibition of ISG20 transcription.Collectively,these findings characterize the role of ISG20 in suppressing PRV replication and increase the understanding of host-PRV interplay. | Xiaoyong Chen Dage Sun Sujie Dong Huanjie Zhai Ning Kong Hao Zheng Wu Tong Guoxin Li Tongling Shan Guangzhi Tong | 2021 | Virologica Sinica2021，36，5： | 4 |
| 9 | A series of 64 cases of pancreatic cystic neoplasia from an institutional study of China显示文摘AIM: To recognize cystic neoplasia of the pancreas and thus to identify a panel of curable diseases. METHODS: Sixty-four cases of cystic neoplasia of the pancreas, including 28 cases of intraductal papillary mucinous neoplasia (IPMN), 12 cases of serous cystic neoplasia (SCN), 11 cases of mucinous cystic neoplasia (MCN), 11 cases of solid pseudo-papillary neoplasia (SPN), and 2 cases of solid tumor with cystic degeneration were examined immunohistochemically for their expression of MUC1, MUC2, MUC4, MUC5AC, and MUC6, as well as other related antigens. RESULTS: Adenoma type of IPMN and borderline lesions exhibited high expressions of MUC2, and MUC5AC. In contrast, IPMN with invasive carcinoma component showed MUC1 immunoreactivity. SCN was mainly positive for MUC1 and MUC6, while negative for MUC2, MUC4 and MUC5AC. Noninvasive MCN, regardless of its cellular atypia degree, was positive for MUC5AC and negative for MUC1. MUC1 expression was only observed in patients with an invasive component. No mucin expression was found in SPN. CONCLUSION: Mucin profile may, in conjunction with histologic study, provide important information on tumor types and patient treatment of cystic neoplasia of the pancreas. | Yuan Ji Wen-Hui Lou Da-Yong Jin Tian-Tao Kuang Meng-Su Zeng Yun-Shan Tan Hai-Ying Zeng Akesu Sujie Xiong-Zeng Zhu | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 10 | Cu2O-Au Nanocomposites with Novel Structures and Remarkable Chemisorption Capacity and Photocatalytic Activity显示文摘在水的答案的 CuH nanoparticles 的分解成功地为 Cu2O nanoparticles 的准备作为一个新奇方法被开发了。特别地,我们发现在水的答案的 CuH nanoparticles 的分解能被 Au 胶体催化,形成 Cu2O-Au nanocomposites。产生 Cu2O-Au nanocomposites 的作文和结构被诱导地联合的血浆详细描绘了原子排放光谱学,粉末 X 光检查衍射, N2 吸附解吸附作用等温线,红外线的光谱学, X 光检查光电子光谱学,扫描电子显微镜学和传播电子显微镜学。他们向各种各样的染料分子的 visible-light-driven photocatalytic 活动也被调查了。取决于 Au : Cu 比率, Cu2O-Au nanocomposites 展览包括由多晶的 Cu2O,非结晶的 Cu2O 和 Au 组成的美丽的象花的 nanostructure 的不同新奇 nanostructures 胶体。我们建议 H2 的快产生的水泡在催化分解反应的功课期间驱使同时形成的 Cu2O 形成非结晶的弄弯的薄陪衬并且当装配的一个模板弄弯非结晶的 Cu2O,多晶的 Cu2O 和 Au 胶体的薄陪衬进一致 nanostructures,可能也行动。有 Cu 的 Cu2O-Au nanocomposite : 40 的 Au 比率向甲基橘子和酸橘子展出显著化学吸着能力和 visible-light-driven photocatalytic 活动 7 并且是有希望的化学吸着光催化综合催化剂。金属氢化物的催化分解可能与新奇 nanostructures 和性质为另外的金属 / 金属氧化物 nanocomposites 的制造开创一条新途径。 | Qing Hua Fucheng Shi Kai Chen Sujie Chang Yunsheng Ma Zhiquan Jiang Guoqiang Pan Weixin Huang | 2011 | Nano Research2011，4，10： | 3 |
| 11 | Structural insights into Ca^2+-activated long-range allosteric channel gating of RyR1显示文摘Ryanodine 受体(RyRs ) 是有分子的质量的巨大的离子隧道的一个班超过 2.2 大 -- 道尔顿。这些隧道调停钙在许多房间发信号。因为超过 80% RyR 蛋白质被合拢进细胞质的集会,留下的残余形成 transmembrane 领域, RyR 隧道的激活和规定发生通过,这被假设了一迄今为止 uncharacterized 远程的 allosteric 机制。这里,我们报导 Ca 2+-activated 的描述由 cryo 电子的开状态的 RyR1 结构显微镜学。结构有 4.9 Å 的一个全面决定;并且 4.2 Å 的一个决定;为核心区域。与以前坚定的 apo/closed-state 结构比较,我们在 Ca 2+ 激活之上观察了隧道的远程的 allosteric gating。深入的结构的分析阐明了新奇隧道门机制和 RyR1 的新奇离子选择机制。我们的工作不仅提供结构的卓见进隧道 gating 和 RyRs 的规定的分子的机制,而且为 six-transmembrane-helix 阳离子隧道家庭为隧道门和离子选择机制使结构的基础清楚些。 | Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin | 2016 | Cell Research2016，26，9： | 3 |
| 12 | Clinical and histopathological alterations of lymphangioleiomyomatosis in 14 Chinese patients显示文摘背景 Lymphangioleiomyomatosis (打)主要影响年轻 females.It 的稀罕疾病作为一个“孤儿”被认为未知病原学的威胁生活的疾病与不明确的临床的预后,并且没有有效 treatment.LAM 能偶发地或与有块茎的硬化建筑群( TSC )联合产生,正染色体的继承症候群由从肺的 LAM.The 临床的路线的表明是不同的象hamartoma一样肿瘤生长和病理学的特征描绘了打是 | LU Shao-hua HOU Ying-yong TAN Yun-shan XU Jian-fang ZENG Hai-ying SUJIE A-kesu WANG Xiang-dong BAI Chun-xue | 2009 | Chinese Medical Journal2009，，16： | 3 |
| 13 | Prospect of new pumped-storage power station显示文摘In this paper, a new type of pumped-storage power station with faster response speed, wider regulation range, and better stability is proposed. The operational flexible of the traditional pumped-storage power station can be improved with variable-speed pumped-storage tech no logy. Combined with chemical en ergy storage, the failure to achieve sec on d-order response speed and the insufficient safety and reliability of pumped-storage power units could be solved. With the better solar en ergy and site resources, the in teg rated performance can be improved by an optical storage system in stalled in future pumped-storage stations. Through the characteristics analysis of the new type of pumped-storage power station, three types of optimal station locations are proposed, namely, the load concentration area, new energy concentration area, and ultrahigh- voltage direct current receiver area. Taking the new pumped-storage power station as an example, the advantages of multi-energy cooperation and joint operation are analyzed. It can be predicted that the frequency and load regulation of the power grid will be more flexible, and the service capacity to the main power grid will be much stronger in the future. | Jingyan Li Chuanbao Yi Sujie Gao | 2019 | Global Energy Interconnection2019，2，3： | 3 |
| 14 | Blockchain-Based Reliable Fog-Cloud Service Solution for IIoT显示文摘Industrial Internet of things(IIoT)deploys a large number of smart devices to obtain industrial data,which will be transmitted to cloud for analysis to improve industrial productivity.The management of large-scale devices is complicated,and it’s also a challenge to choose a high-quality cloud service for data analysis as the number of service with similar functions increases.To address these issues,we propose a reliable fog-cloud service solution with blockchain-based fog-cloud architecture.In fog layer,we build a management blockchain between fog servers and design a management method for industrial devices;In cloud layer,we construct a service blockchain between cloud service providers to form an open'service market'.Quality of service and reputation based matching algorithm and reputation-based consensus algorithm are designed.The simulation results show correctness and efficiency of algorithms,and validate effectiveness of our proposed solution. | DAI Meiling XU Siya SHAO Sujie GUO Shaoyong QIU Xuesong XIONG Ao | 2021 | Chinese Journal of Electronics2021，30，2： | 3 |
| 15 | A sensorless efficiency test system for a high-speed permanent magnet synchronous motor显示文摘We present a sensorless efficiency test system with energy recovery for a high-speed permanent magnet synchronous motor(PMSM). In the system, two identical high-speed PMSMs are used as the motor under test(MUT)and the load machine(LM),respectively.A new sensorless vector control(VC) method based on a hypothetical reference frame is presented to control both the MUT and the LM.Also,a regenerating unit is used to implement energy circulation to save energy.Experiments were carried out on a prototype, with a digital controller based on the TMS320 F28335, to verify the adequacy of the sensorless VC method.As a result,the efficiency test system achieves the load test at the speed of 21000 r/min without any reduction equipment. During the test, the energy regenerated by the LM could be fed back to the MUT by the regenerating unit, and 81.31% electrical power was saved.In addition, with the proposed sensorless VC method,both the MUT and the LM can work at i_d = 0 without a position sensor. | Li JI Yixiang SHAO Sujie GAO | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 3 |
| 16 | Therapy-Related Acute Myeloid Leukemia in A Primary Pulmonary Leiomyosarcoma Patient with Skin Metastasis显示文摘Primary pulmonary leiomyosarcoma (LMS) is a very unusual tumor.Although LMS has well-known metastatic potential,cutaneous metastasis is a remarkably uncommon.Exposure to cytotoxic agents could lead to 'therapy-related myeloid neoplasm' (t-MN).Starting from 2008,the World Health Organization (WHO) has adopted the term to cover the spectrum of malignant diseases previously known as therapy-related acute myeloid leukemia (t-AML),therapy-related myelodysplastic syndrome (t-MDS) and therapy-related myelodysplastic/myelo-proliferative neoplasm (t-MDS/MPN).We described the onset of t-MDS and progression to t-AML in one case diagnosed as primary pulmonary LMS with cutaneous metastasis.This patient achieved complete remission (CR) after three courses of IA regimen chemotherapy (idarubicin 5 mg/d,d 1-3;cytarabine 100 mg/d,d 1-5) and 1 course of HA chemotherapy regimen (homoharringtonine 3 mg/d,d 1-3;cytarabine 100 mg/d,d 1-7).This case presents the natural course of therapy-related neoplasm and provides therapeutic experience for t-AML. | Yan Ma Bo-bin Chen Xiao-ping Xu Guo-wei Lin Yuan Ji Sujie Akesu Haiying Zen | 2011 | Chinese Journal of Cancer Research2011，23，3： | 2 |
| 17 | Effects of Deformation and Phase Transformation Microstructures on Springback Behavior and Biocompatibility in β-Type Ti-15Mo Alloy显示文摘This study examined the mechanical properties, springback behavior from three-point bending loading–unloading tests and biocompatibility from human osteoblast cell adhesion and proliferation experiments in Ti-15Mo alloy with different microstructures. The springback ratio increased after the appearance of deformation microstructures including {332} < 113 > twins and dislocations, due to the increased bending strength and unchanged Young’s modulus. By contrast, the change in springback ratio was dependent on the competing effect of the simultaneous increase in bending strength and Young’s modulus after phase transformation, namely, the isothermal ω-phase formation. Good cell adhesion and proliferation were observed on the alloy surface, and they were not significantly affected by the deformation twins, dislocations and isothermal ω-phase.The diversity of deformation and phase transformation microstructures made it possible to control the springback behavior effectively while keeping the biocompatibility of the alloy as an implant rod used for spinal fixation devices. | Sujie Zhang Xiaohua Min Yada Li Weiqiang Wang Ping Li Mingjia Li | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，4： | 2 |
| 18 | A simple, flexible and high-throughput cloning system for plant genome editing via CRISPR-Cas system显示文摘CRISPR-Cas9 system is now widely used to edit a target genome in animals and plants. Cas9 protein derived from Streptococcus pyogenes(Sp Cas9) cleaves double-stranded DNA targeted by a chimeric single-guide RNA(sg RNA). For plant genome editing, Agrobacterium-mediated T-DNA transformation has been broadly used to express Cas9 proteins and sg RNAs under the control of Ca MV 35 S and U6/U3 promoter, respectively. We here developed a simple and high-throughput binary vector system to clone a 19 20 bp of sg RNA, which binds to the reverse complement of a target locus, in a large T-DNA binary vector containing an Sp Cas9 expressing cassette. Twostep cloning procedures:(1) annealing two target-specific oligonucleotides with overhangs specific to the Aar I restriction enzyme site of the binary vector; and(2) ligating the annealed oligonucleotides into the two Aar I sites of the vector, facilitate the high-throughput production of the positive clones. In addition, Cas9-coding sequence and U6/U3 promoter can be easily exchanged via the GatewayTMsystem and unique Eco RI/Xho I sites on the vector, respectively. We examined the mutation ratio and patterns when we transformed these constructs into Arabidopsis thaliana and a wild tobacco, Nicotiana attenuata. Our vector system will be useful to generate targeted large-scale knock-out lines of model as well as non-model plant. | Hyeran Kim Sang-Tae Kim Jahee Ryu Min Kyung Choi Jiyeon Kweon Beum-Chang Kang Hyo-Min Ahn Suji Bae Jungeun Kim Jin-Soo Kim Sang-Gyu Kim | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 19 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 20 | Effects of linker amino acids on the potency and selectivity of dimeric antimicrobial peptides显示文摘Dimerization is an effective strategy for designing antimicrobial peptides that combine the advantages of different native peptides. In this study, we explored the effects of different linker amino acids, including leucine, proline and aminocaproic acid, on the anticancer, antimicrobial and hemolytic activities of the heteromeric antimicrobial peptides AM-1, AM-2, and AM-3. Proline and aminocaproic acid are ideal linkers for increasing the potency and selectivity of heteromeric antimicrobial peptides. The results of MD simulations provided a rationalization for this observation. Both AM-2, which had a proline linker,and AM-3, which had an aminocaproic acid linker, adopted a compact conformation in water and a bent conformation in membranes. This change in the flexible structures of AM-2 and AM-3 could have resulted in decreased binding of these peptides to zwitterionic lipid bilayers and increased damage to mixed lipid bilayers containing acidic phospholipids. In short, these findings obtained via assessing the effects of linker amino acids will contribute to the design of ideal heteromeric antimicrobial peptides with high selectivity and potency. | Ming Kai Wei Zhang Huan Xie Liwei Liu Sujie Huang Xiao Li Zhengzheng Zhang Yuyang Liu Bangzhi Zhang Jingjing Song Rui Wang | 2018 | Chinese Chemical Letters2018，29，7： | 2 |
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