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| 1 | 实验性自身免疫性葡萄膜视网膜炎中浸润细胞的表型及其凋亡的研究显示文摘目的 探讨实验性自身免疫性葡萄膜视网膜炎 (experimental autoimmune uveoretinitis,EAU)中参与的细胞表型及其凋亡。 方法 用光感受器间维生素 A类结合蛋白 (interphotoreceptorretinoid- binding protein,IRBP)免疫 16只 L ewis鼠后 ,于眼组织切片和平片上进行免疫组织化学染色和原位凋亡染色 ,所用抗体为抗单核细胞、巨噬细胞 (EDI)、MHC- 类抗原 (OX6 )、T淋巴细胞 (R73)的单克隆抗体 ,所用原位凋亡试剂盒为 TACS1Klenow。 结果 用 IRBP免疫 L ewis鼠后 ,16只鼠中 12只发生了临床可见的葡萄膜炎 ,炎症平均得分为 1.2 9± 0 .7级 ;免疫组织化学染色发现葡萄膜和视网膜中有大量的单核细胞、淋巴细胞及 MHC- +细胞浸润 ,这些组织中均可见浸润细胞的凋亡 ,虹膜睫状体中凋亡细胞明显多于脉络膜和视网膜中的凋亡细胞。 结论 单核巨噬细胞、淋巴细胞和 MHC- +细胞均参与了 EAU的形成 ,在 EAU早期即有浸润细胞发生凋亡 ,此可能是导致这种炎症迅速消退的重要机制。 | 杨培增 Nicole H Herzberg 周红颜 黄祥坤 谢楚芳 金浩丽 籍利 Lidy Broersma Mavc D de Smet Aize Kijlstra | 2000 | 中华眼底病杂志2000，16，1： | 9 |
| 2 | Current status of ultrasound-guided surgery in the treatment of breast cancer显示文摘The primary goal of breast-conserving surgery(BCS) is to obtain tumour-free resection margins. Margins positive or focally positive for tumour cells are associated with a high risk of local recurrence, and in the case of tumour-positive margins, re-excision or even mastectomy are sometimes needed to achieve definite clear margins. Unfortunately, tumour-involved margins and re-excisions after lumpectomy are still reported in up to 40% of patients and additionally, unnecessary large excision volumes are described. A secondary goal of BCS is the cosmetic outcome and one of the main determinants of worse cosmetic outcome is a large excision volume. Up to 30% of unsatisfied cosm-etic outcome is reported. Therefore, the search for better surgical techniques to improve margin status, excision volume and consequently, cosmetic outcome has continued. Nowadays, the most commonly used localization methods for BCS of non-palpable breast cancers are wire-guided localization(WGL) and radioguided localization(RGL). WGL and RGL are invasive procedures that need to be performed pre-operatively with technical and scheduling difficulties. For palpable breast cancer, tumour excision is usually guided by tactile skills of the surgeon performing 'blind' surgery. One of the surgical techniques pursuing the aims of radicality and small excision volumes includes intraoperative ultrasound(IOUS). The best evidence available demonstrates benefits of IOUS with a significantly high proportion of negative margins compared with other localization techniques in palpable and non-palpable breast cancer. Additionally, IOUS is non-invasive, easy to learn and can centralize the tumour in the excised specimen with low amount of healthy breast tissuebeing excised. This could lead to better cosmetic results of BCS. Despite the advantages of IOUS, only a small amount of surgeons are performing this technique. This review aims to highlight the position of ultrasoundguided surgery for malignant breast tumours in the search for better oncological and cosmetic outcomes. | José H Volders Max H Haloua Nicole MA Krekel Sybren Meijer Petrousjka M van den Tol | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 3 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 4 | 在有症状的患者中,与传统危险因素相比,冠状动脉钙化积分能更准确地预测显著的冠状动脉狭窄:欧洲钙化性冠状动脉疾病研究显示文摘在这项回顾性研究中,研究人员评估了冠状动脉钙化积分相对于传统危险因素对显著狭窄(冠状动脉狭窄〉50%)的预测价值。方法与结果:纳入来自丹麦、法国、德国、意大利、西班牙和美国有症状的患者5515例,所有研究对象均进行危险因素评估、计算机断层冠状动脉造影(computed tomographic coronary angiogram,CTCA)或常规血管造影。 | 刘莉 叶鹏 Nicoll R Wiklund U Zhao Y Diederichsen A Mickley H Ovrehus K Zamorano P Gueret P Schmermund A Maffei E Cademartiri F Budoff M Henein M | 2016 | 中华高血压杂志2016，24，3： | 4 |
| 5 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 6 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 7 | Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in bums显示文摘 | John H Tinsley Nicole R | 2004 | Am J Physiol Lung Cell Mol Physiol2004，28，4： | 1 |
| 8 | Anti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-γ or IL-4显示文摘 | Nicolls MR Coulombe M Yang H | 2000 | J Immunol2000，164，7： | 1 |
| 9 | Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns显示文摘 | John H Tinsley Nicole R | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，4： | 1 |
| 10 | Chronic ethanol consumption restores the age-related decrease in neurogranin mRNA level in the hippocampus of mice 显示文摘 | Ali K Nicole M Paul H | 2003 | Neurosci Lett2003，338，： | 1 |
| 11 | Differential expression of protein and mRNAs from border cells and root tips of pea显示文摘 | BRIGHAM L A WOO H H NICOLL S M | 1995 | Plant Physiol1995，109，： | 1 |
| 12 | Losses in three-phaseinduction machines fed by PWM converter 显示文摘 | Nicol Hildebrand E Roehrdanz H | 2001 | IEEETransactions on Energy Conversion2001，16，3： | 1 |
| 13 | C]inical evaluation of autologous gamma delta T cell-basedimmunotherapy for metastatic solid tumours显示文摘 | Nicol AJ Tokuyama H Mattarollo 81{ | 2011 | British J Oancer2011，6，105： | 1 |
| 14 | Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours显示文摘 | Nicol AJ Tokuyama H Mattarollo SR | 2011 | Br J Cancer2011，105，6： | 1 |
| 15 | Inducible expression of tissue factor in small-cell lung cancer:impact on morphology and matrix met alloproteinase secretion显示文摘 | NICOLE H MARGARETHE II RAINER S | 2012 | Canner Res Clin Onca12012，138，4： | 1 |
| 16 | Applying trusted network technology to process control systems 显示文摘 | OKHRAVI H NICOL D | 2009 | Critical Infrastructure Protection Ⅱ The International Federation for Information Processing2009，290，： | 1 |
| 17 | Neon and helium isotopes as tracers of mantle reservoirs and mantle dynamics 显示文摘 | Nicole S Samuel N Karsten H | 2007 | Earth and Planetary Science Letters2007，，258： | 1 |
| 18 | Differential proliferative response of NKT cell subpopulation to in vitro stimulation in presence of different cytokines显示文摘 | LIU H NIEDA M NICOL A J | 2004 | Eur J Immuniol2004，34，： | 1 |
| 19 | A general approach to desalting oligosaccharides released from glycoproteins显示文摘 | Nicolle H Packer Margaret A Lawson Daniel R Jardine John W Redmond | 1998 | Glycoconjugate Journal1998，，8： | 1 |
| 20 | A single comprehensive non-in- vasive eardiovascular assessment in pulmonary and coronary an- giograpny显示文摘 | Nicol ED Kafka H stirrup J | 2009 | Intemationd Joumal of cardiology2009，136，3： | 1 |
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