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| 1 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 2 | 大鼠孕期外源性邻苯二甲酸二丁酯和己烯雌酚暴露会改变子代雄性大鼠间质细胞发育显示文摘孕期外源性雌激素和邻苯二甲酸酯类暴露会致使早期生殖发育畸形,从而导致男性睾丸源性生殖障碍综合征的出现。然而,对于受孕初期利哺乳期暴露是否会影响子代间质细胞表型还不清楚。本文检测了SD大鼠孕期和哺乳期邻笨二甲酸二丁酯和己烯雌酚短期暴露后,其雄性了代出生后的一些罩丸参数。在整个研究过程中,子代保持了良好的健康状态。母鼠给予外源性物质后,其子代的间质细胞的特定基因表达发生了改变。尤其是在青春期的中期,这些化合物致使血中INSL3的浓度迅速达到峰值。这一效果部分是由于两种外源性物质对青春期大鼠睾丸间质细胞分化有特定的作用。总之,以上这些实验结果表明孕期某些外源性物质暴露能够影响成年型间质细胞群体的发育,这可能是通过影响睾丸间质干细胞群实现的。 | Richard Ivell Kee Heng Helen Nicholson Ravinder Anand-Ivell | 2013 | Asian Journal of Andrology2013，15，2： | 6 |
| 3 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 4 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis显示文摘 | Nicholson DW Ali A Thornberry NA | | 0，，： | 4 |
| 5 | The SOCS proteins:A new family of negative regulators of signal transduction 显示文摘 | Nicholson S E Hilton D J | 1998 | J Leukoc Biol1998，63，6： | 3 |
| 6 | Biology and significance of the JAK/STAT signalling pathways显示文摘 | Hiu Kiu Sandra E. Nicholson | 2012 | Growth Factors2012，，2： | 3 |
| 7 | Caspases:killer proteases显示文摘 | Nicholson DW Thomberry NA | | 0，，： | 3 |
| 8 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 9 | ’Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | J. K. Nicholson J. C. Lindon E. Holmes | 1999 | Xenobiotica1999，，11： | 3 |
| 10 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 11 | Heavy metal contents of livestock feeds and animal manures in England and Wales显示文摘 | F.A Nicholson B.J Chambers J.R Williams R.J Unwin | 1999 | Bioresource Technology1999，，1： | 2 |
| 12 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 13 | ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | Nicholson JK Lindon JC Holmes E | 1999 | Xenobiotica1999，29，11： | 2 |
| 14 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 15 | Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids显示文摘 | Lindon JC Nicholson JK Holmes E Everett JR | 2000 | Concepts Magn Reson2000，12，5： | 2 |
| 16 | 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma显示文摘 | Nicholson JK Foxall PJ Spraul M Farrant RD Lindon JC | 1995 | Anal Chem1995，67，5： | 2 |
| 17 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson JK Connelly J Lindon JC Holmes E | 2002 | Nat Rev Drug Discov2002，1，2： | 2 |
| 18 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 19 | An inventory of heavy metals inputs to agricultural soils in England and Wales显示文摘 | F.A. Nicholson S.R. Smith B.J. Alloway C. Carlton-Smith B.J. Chambers | 2003 | Science of the Total Environment2003，，1： | 2 |
| 20 | Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabialistic neural networks显示文摘 | Holmes E Nicholson JK Tranter G | 2001 | Chem Res Toxicol2001，14，2： | 2 |
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