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| 1 | Current therapy of hilar cholangiocarcinoma显示文摘BACKGROUND: Hilar cholangiocarcinoma (HC) is an adeno-carcinoma of the extrahepatic biliary tree arising from the main left or right hepatic ducts or their confluence. This tumor is still considered to be difficult to treat or to cure. DATA SOURCES: We reviewed the medical literature on HC. Relevant and updated information on this tumor was analyzed in a concise and easy-to-read manner. The article is not intended to be a systematic review, but an extensive search was conducted on PubMed and MEDLINE using the keywords 'hilar cholangiocarcinoma' and 'Klatskin tumor' until July 2011. RESULTS: The selection and the timing of management options for patients with HC are determined by the degree of certainty of the diagnosis, the general condition of the patients, the underlying liver function and the stage of the disease. Current treatment of HC can be divided into curative and palliative treatment. For the curative treatment, local excision should only be used on small tumors which are confined to the bile duct wall and Bismuth I papillary carcinoma. Partial hepatectomy should be combined with caudate lobe resection and porta-hepatis lymph node dissection. The results of these major resections can be improved with portal vein embolization, and staging laparoscopy and laparoscopic ultrasound. The role of preoperative biliary drainage is controversial. Autotransplantation for HC gave disappointing results while the Mayo Protocol of chemoradiation for selecting patients with unresectable HC for orthotopic liver transplantation has been widely accepted. Palliative treatment included bypass surgery, endoscopic or percutaneous stenting, photodynamic therapy, intraluminal brachytherapy, and external radiation and systemic therapy. CONCLUSIONS: Adequate surgery with R0 resection should be the main goal of treatment. For patients with unresectable HC, treatment aims to improve the quality and quantity of their survival. | Stephanie Hiu Yan Lau Wan Yee Lau | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 6 |
| 2 | The current role of radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Local ablative therapy is used in treating liver tumors by either injection of cytotoxic agents(chemicals,radioactive isotopes,hyperthermic agents or chemotherapeutic agents)or application of an energy source to achieve thermal ablation,cryoablation or conformal external beam radiation(Table 1). | Wan Yee Lau Stephanie Hiu Yan Lau | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 5 |
| 3 | Effect of UV-B Radiation on Ingesting and Nutritional Selecting Behavior of Rotifer Brachionus urceus显示文摘Effect of UV-B radiation on ingesting and nutritional selecting behavior of the roifer Brachionus urceus on 5 species of micro-algae were studied under controlled laboratory conditions. Results showed that enhanced UV-B radiation significantly inhibited ingesting of the rotifer B. urceus when it was fed with 5 species of micro-algae (p<0.05). The ingesting selectivity rate varied with the UV-B radiation enhancement when it was fed with 5 species micro-algal mixture. Results indicated that the enhanced UV-B radiation could affect ingesting and nutritional selectivity of B. urceus. | FENG Lei TANG Xuexi WANG You XIAO Hiu MENG Xianghong CHEN Xiguang | 2007 | Wuhan University Journal of Natural Sciences2007，12，2： | 4 |
| 4 | Imaging of the anterior cruciate ligament显示文摘The anterior cruciate ligament(ACL)is an important structure in maintaining the normal biomechanics of the knee and is the most commonly injured knee ligament.However,the oblique course of the ACL within the intercondylar fossa limits the visualization and assessment of the pathology of the ligament.This pictorial essay provides a comprehensive and illustrative review of the anatomy and biomechanics as well as updated information on different modalities of radiological investigation of ACL,particularly magnetic resonance imaging. | Wing Hung Alex Ng James Francis Griffith Esther Hiu Yee Hung Bhawan Paunipagar Billy Kan Yip Law Patrick Shu Hang Yung | 2011 | World Journal of Orthopedics2011，2，8： | 4 |
| 5 | Biology and significance of the JAK/STAT signalling pathways显示文摘 | Hiu Kiu Sandra E. Nicholson | 2012 | Growth Factors2012，，2： | 3 |
| 6 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 7 | Synthesis of Constrained Head‐to‐Tail Cyclic Tetrapeptides by an Imine‐Induced Ring‐Closing/Contraction Strategy显示文摘 | Clarence T. T. Wong Hiu Yung Lam Tao Song Guanhua Chen Xuechen Li | 2013 | Angew Chem Int Ed2013，，39： | 2 |
| 8 | External Control,Corporate Strategy and Firm Performance in Research-Intensive Industries 显示文摘 | C W L HiU S A Snell | 1999 | Strategie Management Journal1999，9，6： | 1 |
| 9 | Analytical determination of nicotine in tobacco by supercritical fluid chromatography-ion mobility detection 显示文摘 | WuC Siems W F Hiu H H | 1998 | J Chromatography A1998，811，12： | 1 |
| 10 | Membrane bioreactor for the drinking water treatment of polluted surface water supplies显示文摘 | Xiao-yan Li Hiu Ping Chu | 2003 | Water Research2003，，37： | 1 |
| 11 | Microbial biomass estimated by phospholipids phosphate in soil with diverse microbial communities显示文摘 | Hiu T C J McPherson E F Harris J A | 1993 | Soil Biochem1993，25，： | 1 |
| 12 | Enhancement effect of Ag for Pd/C towards the ethanol electro-oxidation in alkaline media显示文摘 | Son Truong Nguyen Hiu Mung Law Hoa Tien Nguyen Noel Kristian Shuangyin Wang Siew Hwa Chan Xin Wang | 2009 | Applied Catalysis B, Environmental2009，，1： | 1 |
| 13 | Core/Shell Particles Containing 3-(Methacryloxypropyl)-Trimethoxysilane in the Shell:Synthesis, Characterization, and Application显示文摘 | Cao S S hiu B Deng X Li S | 2005 | Macromol Biosci2005，5，： | 1 |
| 14 | Generation and use of high - quality cDNA from small amounts of total RNA by SMART PCR 显示文摘 | Chenchik A Zhu Y Y Diatchenko L Li R Hiu J & Siebert P D | 1998 | Biotechniques1998，，： | 1 |
| 15 | Efficacy of DynaCT digital angiography in the detection of the fistulous point of dural arteriovenous fistulas显示文摘 | Hiu T Kitagawa N Morikawa M Hayashi K Horie N Morofuji Y | 2009 | AJNR AmJ Neuroradiol2009，30，： | 1 |
| 16 | Ultrasound-guided perivascular axillary brachial plexus block: not so simple 显示文摘 | Hiu WM Mritunjay V | 2013 | Reg Anesth PainMed2013，38，2： | 1 |
| 17 | Laparoscopic colorectal resection: a safe option for elderly patients显示文摘 | Wai Lun Law Kin Wah Chu Peter Hiu Ming Tung | 2002 | Journal of the American College of Surgeons2002，，： | 1 |
| 18 | Video Respite : an innovative resource for family, professional caregivers, and persons with dementia 显示文摘 | Lurid DA HiU RD Caserta MS | 1995 | Gerontologist1995，35，5： | 1 |
| 19 | Presentation of antigen by mixed isotypeclass Ⅱ molecules in normal H-2 mice 显示文摘 | Ruler G Sellins K S Hiu C M | 1992 | J Exp Med1992，175，1： | 1 |
| 20 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
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