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| 1 | Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy显示文摘Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction. | Vyacheslav I Egorov Roman V Petrov Michail V Lozhkin Olga A Maynovskaya Natalia S Starostina Natalia R Chernaya Ekaterina M Filippova | 2013 | World Journal of Gastrointestinal Surgery2013，5，3： | 7 |
| 2 | Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability显示文摘AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery. | Vyacheslav I Egorov Roman V Petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 4 |
| 3 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 4 | Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants显示文摘 | Nikolai V K Irina A R Natalia A I | 2002 | J Gen Virol2002，83，： | 1 |
| 5 | Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis显示文摘 | NATALIA I ALEXEI S IAIN A | 2003 | Nature2003，423，： | 1 |
| 6 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 7 | Laccase eatalysed oxidation of syringic acid: Calorimetric determination of kinetic parameters 显示文摘 | NATALIA V VICTOR I RAJNI H K | 2012 | Enzyme and Microbial Technology2012，，50： | 1 |
| 8 | Structure of anti- gen-ic sites on the haemagglutinin molecule of H5 avian influen- za v-irus and phenotypic variation of escape mutants 显示文摘 | Nikolai V K Irina A R Natalia A I | 2002 | J Gen Virol2002，83，： | 1 |
| 9 | Hyaluronan induces migration of muhidrug-resistant lymphoma cell lines in vitro through Tiaml activation by a PI3K-dependent mechanism 显示文摘 | Cordo-Russo R I Alaniz L D A Natalia S | 2010 | Leuk Res2010，134，： | 1 |
| 10 | Pseudorotaxane complexes between viologen vinylogues and cueurbit uril: New prototype of photocontrolled molecular machine 显示文摘 | Artem I V Natalia A L Lyudmila G K | 2011 | Journal of Mo- lecular Structure2011，989，13： | 1 |
| 11 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 12 | Chain of custody certification : an assessment of North American solid wood sec- tor显示文摘 | I Natalia Vidal Robert Kozak David Cohen | 2005 | Forest Policy & Economics2005，，3： | 1 |
| 13 | Metagenomic and Functional Analysis of Hindgut Microbiota of a Wood-feeding Higher Termite 显示文摘 | FALK W PETER L NATALIA I | 2007 | Nature2007，450，22： | 1 |
| 14 | Dynamical stability of Fe - H in the Earth' s mantle and core regions 显示文摘 | EYVAZ I I NATALIA V S RAJEEV A | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 15 | Selective dehydrolinalool hydrogenation with poly(ethylene oxide)- block -poly-2-vinylpyridine micelles filled with Pd nanoparticles显示文摘 | Natalia V Semagina Alexei V Bykov Esther M Sulman Valentina G Matveeva Stanislav N Sidorov Lidia V Dubrovina Peter M Valetsky Olga I Kiselyova Alexei R Khokhlov Barry Stein Lyudmila M Bronstein | 2003 | Journal of Molecular Catalysis A Chemical2003，，1： | 1 |
| 16 | Microsatellite genetic variation of Asian populations of Dolly Varden char显示文摘 | Natalia V Gordeeva Evgenia I Chukova Alia G | 2010 | Hydrobiologia2010，650，： | 1 |
| 17 | Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide显示文摘 | Natalia I Assaf F Przemyslaw B | 2003 | PNAS2003，100，13： | 1 |
| 18 | Universal primer cocktails for fish DNA barcoding 显示文摘 | Natalia V I Tyler S Z Robert H H | 2007 | Molecular Ecology Notes2007，7，4： | 1 |
| 19 | S-Adenosylmethionine blocks collagen I production by preventing transforming growth fac- tor-fl induction of the COL1A2 promoter 显示文摘 | NATALIA N ARTHUR I C | 2005 | J Bio Chem2005，，30： | 1 |
| 20 | Low density polyethylene – Chitosan composites显示文摘 | Cornelia Vasile Raluca Nicoleta Darie Catalina Natalia Cheaburu-Yilmaz Gina-Mihaela Pricope Matej Bra?i? Daniela Pamfil Gabriela Elena Hitruc Donatella Duraccio | 2013 | Composites Part B2013，，： | 1 |
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