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	题名	作者	年代	出处	被引量
1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
2	Cancer stem cells: markers or biomarkers?显示文摘	Wendy A. Woodward Erik P. Sulman	2008	Cancer and Metastasis Reviews2008，，3：	2
3	Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer显示文摘	Sulman EP Komaki R Klopp AH	2009	Radiat Oncol2009，4，：	1
4	Support like a walking stiek : parent-buddy matehing for language and euhure in the NICU 显示文摘	Ardal F Sulman J Fuller-Thomson E	2011	Neonatal Network: J Neonatal Nurs2011，30，2：	1
5	3-year actuarial biochemical recurrence-free survival following laparoscopic radical prostatectomy:Experience from a tertiary referal center in the United States显示文摘	Pavlovich CP Troek BJ Sulman A	2008	J Urol2008，179，3：	1
6	Multigene sets for clinical application in glioma 显示文摘	deGroot JF Sulman EP Aldape KD	2011	J Natl Compr CancNetw2011，9，4：	1
7	Modeling soil and biomass carbon responses to declining water table in a wetland- rich landscape显示文摘	Sulman B N Desai A R Mladenoff D J	2013	Ecosystems2013，16，3：	1
8	Molecular markers in low-grade glioma-toward tumor reclassification显示文摘	Olar A Sulman EP	2015	Semin Radiat Oncol2015，25，3：	1
9	Brain tumor stem cell 显示文摘	Sulman E Aldape K Colman H	2008	Curr Probl Cancer2008，32，3：	1
10	Mesh between the oblique muscles is simple and effective in open herinioplasty显示文摘	SULMAN AG	1995	Am Surg1995，61，：	1
11	Selective dehydrolinalool hydrogenation with poly(ethylene oxide)- block -poly-2-vinylpyridine micelles filled with Pd nanoparticles显示文摘	Natalia V Semagina Alexei V Bykov Esther M Sulman Valentina G Matveeva Stanislav N Sidorov Lidia V Dubrovina Peter M Valetsky Olga I Kiselyova Alexei R Khokhlov Barry Stein Lyudmila M Bronstein	2003	Journal of Molecular Catalysis A Chemical2003，，1：	1
12	Assage of polymyxins from serum into milk inewes显示文摘	Ziv G Sulman F G	1973	AmJ Vet Res1973，34，：	1
13	Selective dehydrolinalool hydrogenation with poly (ethylene oxide)-block-poly-2-vinylpyridine micelles filled with Pd nanoparticles显示文摘	SEMAGINA N V BYKOV A V SULMAN E M	2004	J Mol Catal A:Chemical2004，208，12：	1
14	Percutaneous com- puterized tomography guided renal cryoablation using local anesthesia: pain assessment 显示文摘	Permpongkosol S Sulman A Solomon SB	2006	J Urol2006，176，5：	1
15	Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer显示文摘	Sulman EP Komaki R Klopp AH		0，，：	1
16	A multigene predictor of outcome in glioblastoma显示文摘	Colman H Zhang L Sulman EP		0，，：	1
17	A multigene predictor of outcome in glioblastoma显示文摘	Colman H Zhang L Sulman EP	2010	Neuro Oncol2010，12，1：	1
18	Knowledge & Teaching: Foundations of the New Reform显示文摘	Sulman L S	1987	Harvard Educational Review1987，，57：	1
19	A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor‐Initiating Cells显示文摘	Norihiko Saito Jun Fu Siyuan Zheng Jun Yao Shuzhen Wang Diane D. Liu Ying Yuan Erik P. Sulman Frederick F. Lang Howard Colman Roel G. Verhaak W. K. Alfred Yung Dimpy Koul	2014	Stem Cells2014，，1：	1
20	ECK, a Human EPH -Related Gene, Maps to 1p36.1, a Common Region of Alteration in Human Cancers显示文摘	Erik P. Sulman Xao X. Tang Cindy Allen Jaclyn A. Biegel David E. Pleasure Garrett M. Brodeur Naohiko Ikegaki	1997	Genomics1997，，2：	1

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