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| 1 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 2 | Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity显示文摘AIM: To investigate the role of type-I left-right bicuspid aortic valve(LR-BAV) hemodynamic stresses in the remodeling of the thoracic ascending aorta(AA) concavity, in the absence of underlying genetic or structural defects.METHODS: Transient wall shear stress(WSS) profiles in the concavity of tricuspid aortic valve(TAV) and LR-BAV AAs were obtained computationally. Tissue specimens excised from the concavity of normal(nondilated) porcine AAs were subjected for 48 h to those stress environments using a shear stress bioreactor. Tissue remodeling was characterized in terms of matrix metalloproteinase(MMP) expression and activity via immunostaining and gelatin zymography.RESULTS: Immunostaining semi-quantification results indicated no significant difference in MMP-2 and MMP-9 expression between the tissue groups exposed to TAV and LR-BAV AA WSS(P = 0.80 and P = 0.19, respectively). Zymography densitometry revealed no difference in MMP-2 activity(total activity, active form and latent form) between the groups subjected to TAV AA and LR-BAV AA WSS(P = 0.08, P = 0.15 and P = 0.59, respectively).CONCLUSION: The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. | Samantha K Atkins Alison N Moore Philippe Sucosky | 2016 | World Journal of Cardiology2016，8，1： | 3 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 5 | On definition of reactive power under non-sinusoidal conditions显示文摘 | Kusters N I Moore W J M | 1980 | IEEE Transactions on Power Apparatus and Systems1980，99，5： | 2 |
| 6 | A review of the effects of electromagnetic stirring(EMS) in continuously cast steels, Part Ⅰ显示文摘 | Shah N A Moore J J | 1982 | Iron and Steelmaker1982，9，10： | 2 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | A survey of current evaluation and treatment of gout显示文摘 | Schlesinger N Moore DF Sun JD | 2006 | J Rheumatol2006，33，： | 1 |
| 9 | Modularity,strategic flexibility,and firm performance:A study of the home appliance industry显示文摘 | WORREN N MOORE K CARDONA P | 2002 | Strategic Management Journal2002，，23： | 1 |
| 10 | Separate pathways for cellular uptake of ferric and fer- rous iron显示文摘 | CONRAD M E UMBREIT J N MOORE E G | 2000 | American Journal of Physiology : Gastro- intestinal and Liver Physiology2000，279，： | 1 |
| 11 | Induction of macro- phage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes显示文摘 | Mizel S B Honko A N Moors M A | 2003 | J Immunol2003，170，12： | 1 |
| 12 | Gemcitabine plus cisplatin, an active regimen in advanced urothelial cancer: a phase Ⅱ trial of the National Cancer Institute of Canada Clinical Trials Group显示文摘 | Moore M J Winquist EW Murray N | 1999 | J Clin Oncol1999，17，9： | 1 |
| 13 | An analyze of Alpha-Beta pruning显示文摘 | KNUTH D E MOORE R N | 1975 | Artificial Intelligence1975，6，4： | 1 |
| 14 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 15 | Mobilization of metal-- contaminated sediment by ice jam floods 显示文摘 | Moore J N Landrigan E M | 1999 | Environmental Geology1999，37，12： | 1 |
| 16 | Automated phase correction of FT NMR spectra by baseline Optimization显示文摘 | Brown Douglas E Campbell Thomas W Moore Richard N | 1989 | J Magn Reson1989，85，： | 1 |
| 17 | 显示文摘 | WAGNER D D M | 1999 | Can J Chem1999，77，： | 1 |
| 18 | Word-association responses:Comparisons of American and French monolinguals with Canadian monolinguals and bilinguals显示文摘 | Lambert W N Moore | 1966 | Journal of Personality and Social Psychology1966，，3： | 1 |
| 19 | The cytology and cytochemistry of the hemocytes of Mytilus edulis and their responses to experimentally injected carbon particles 显示文摘 | MOORE M N LOWED M | 1977 | Journal of Invertebrate Pathology1977，29，1： | 1 |
| 20 | one machine sequencing algorithm for minimizing the number of late jobs显示文摘 | Moore J M An n job | 1968 | Management Science1968，15，3： | 1 |
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