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| 1 | High-dose-rate intraluminal brachytherapy during preoperative chemoradiation for locally advanced rectal cancers显示文摘AIM:To determine the feasibility and safety of high dose rate intraluminal brachytherapy(HDR-ILBT) boost during preoperative chemoradiation for rectal cancer.METHODS:Between 2008 and 2009,thirty-six patients with locally advanced rectal cancer(≥ T3 or N+),were treated initially with concurrent capecitabine(825 mg/m2 oral twice daily) and pelvic external beam radiotherapy(EBRT)(45 Gy in 25 fractions),then were randomized to group A;HDR-ILBT group(n = 17) to receive 5.5-7 Gy×2 to gross tumor volume(GTV) and group B;EBRT group(n = 19) to receive 5.4 Gy×3 fractions to GTV with EBRT.All patients underwent total mesorectal excision.RESULTS:Grade 3 acute toxicities were registered in 12 patients(70.6%) in group A and in 8(42.1%) in group B.Complete pathologic response of T stage(ypT0) in group A was registered in 10 patients(58.8%) and in group B,3 patients(15.8%) had ypT0(P < 0.0001).Sphincter preservation was reported in 6/9 patients(66.7%) in group A and in 5/10 patients(50%) in group B(P < 0.01).Overall radiological response was 68.15% and 66.04% in Group A and B,respectively.During a median follow up of 18 mo,late grade 1 and 2 sequelae were registered in 3 patients(17.6%) and 4 patients(21.1%) in the groups A and B,respectively.CONCLUSION:HDR-ILBT was found to be effective dose escalation technique in preoperative chemoradiation for rectal cancers,with higher response rates,downstaging and with manageable acute toxicities. | Mutahir Ali Tunio Mansoor Rafi Altaf Hashmi Rehan Mohsin Abdul Qayyum Mujahid Hasan Amjad Sattar Muhammad Mubarak | 2010 | World Journal of Gastroenterology2010，16，35： | 3 |
| 2 | Thymidine kinase 1 regulatory fine-tuning through tetramer formation 显示文摘 | Mutahir Z Clausen AR Andersson KM | 2013 | FEBS J2013，280，6： | 1 |
| 3 | Whole-Pelvis or Bladder-Only Chemoradiation for Lymph Node–Negative Invasive Bladder Cancer: Single-Institution Experience显示文摘 | Mutahir A. Tunio Altaf Hashmi Abdul Qayyum Rehan Mohsin Ahmed Zaeem | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 4 | Thymidine kinase 1 regulatory fine-tuning throughtetramer formation 显示文摘 | Mutahir Z Clausen AR Andersson KM | 2013 | FEBS J2013，280，6： | 1 |
| 5 | Thymidine kinase 1 regulatory fine--tuning through tetramer formation显示文摘 | Mutahir Z Clausen AR Andersson KM | 2013 | FEBS J2013，280，6： | 1 |
| 6 | Thymidine Kinase 1 reg-ulatory fine-tuning through tetramer formation 显示文摘 | Mutahir Z Clausen AR Andereson KM | 2013 | FEBS J2013，280，6： | 1 |
| 7 | Thymidine ki-nase 1 regulatory fine-tuning through tetramer formation 显示文摘 | Mutahir Z Clausen AR’Andersson KM | 2013 | FEBSJ2013，280，6： | 1 |
| 8 | Thymidine kinase 1 regulatory fine-tuning through tetramer formation显示文摘 | Mutahir Z Clausen AR Andersson KM | 2013 | FEBS J2013，280，6： | 1 |
| 9 | Journeys of Growth and Learning显示文摘Traveling is an adventure that opens up your mind to new experiences,cultures and ways of life.During my study in China,I have had the opportunity to visit several cities in this vast country.Each city has its own unique charm and character. | Ahmad Khwaja Mutahir | 2023 | Beijing Review2023，66，22： | 0 |
| 10 | Clinicopathological features and treatment outcomes of brain stem gliomas in Saudi population显示文摘AIM: To analyze experiences to identify treatment outcomes and prognostic factors in a Saudi population.METHODS: Medical records of patients with brainstem gliomas treated from July 2001 to December 2012 were reviewed to identify treatment outcomes of surgery, radiation therapy and chemotherapy and associated prognostic factors in a Saudi population.RESULTS: We analyzed 49 brain stem glioma(BSG) patients from July 2001 to December 2012; 31 of them were males(63.3%) with a median age of 12.6 years(range: 8-64 mo). Twenty-two patients(44.9%) had diffuse intrinsic pontine gliomas(DIPG) and 15(30.6%) presented with focal/tectal BSG. Histopathology was available in 30 patients(61.2%). Median survival time for the whole cohort was 1.5 years. One and two year OS rates were 51.1% and 41.9% respectively. Two year OS rates for focal/tectal, dorsally exophytic, cervicomedullary and DIPG tumors were 60%, 33.3%, 33.3% and 13.6% respectively(P < 0.0001). Significant prognostic factors related to OS were age at diagnosis(worse for > 18 years) P = 0.01, KPS < 70 P = 0.02, duration of symptoms(< 60 d) P = 0.002, histology(better for favorable) P = 0.002, surgery(maximal resection) P = 0.002, and concurrent chemotherapy with radiation therapy in DIPG(better if given) P = 0.01.CONCLUSION: BSG, especially the DIPG subgroup, had a dismal prognosis, needing more aggressive neurosurgical, radiation and chemotherapy techniques, while focal and tectal tumors were found to have a better prognosis. | Yasser Bayoumi Abdulrahman J Sabbagh Reham Mohamed Usama M El Shokhaiby Ahmed Marzouk Maklad Mutahir A Tunio Ali Abdullah O Balbaid | 2014 | World Journal of Clinical Oncology2014，5，5： | 0 |
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