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| 1 | Regulation of TLR7/9 signaling in plasmacytoid dendritic cells显示文摘Plasmacytoid dendritic cells(pDCs),also known as type I interferon(IFN)-producing cells,are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nu-cleic acids derived from virus,bacteria or dead cells.PDCs selectively express endosomal Toll-like receptor(TLR)7 and TLR9,which sense viral RNA and DNA re-spectively.Following type I IFN and cytokine responses,pDCs differentiate into antigen presenting cells and ac-quire the ability to regulate T cell-mediated adaptive immunity.The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance,inflammation and tumor microenvironments.In this review,we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors. | Musheng Bao Yong-Jun Liu | 2013 | Protein & Cell2013，4，1： | 9 |
| 2 | PLSCR1真核表达载体的构建及细胞内定位分析显示文摘分别构建带有myc标签和GFP荧光蛋白的磷脂爬行酶1(PLSCR1)真核表达载体,获得两个融合表达载体,并转入HEK293细胞观察表达情况及细胞内定位,为研究PLSCR1的定位与功能的关系奠定基础。以本实验室保存的Hela c DNA文库为模板,采用PCR技术扩增PLSCR1编码序列,将其分别插入p CMV-Myc-N和p EGFP-C1载体,Western blotting检测其在HEK293中的表达,采用激光共聚焦观察p EGFP-C1融合表达载体在HEK293细胞中定位。通过DNA序列分析,证实了成功构建了PLSCR1真核表达载体,并能在HEK293细胞中实现基因的过表达。成功构建PLSCR1真核表达载体,为进一步研究其功能奠定了基础。 | 王远 陈英 张学清 陈忠民 田喜凤 陈晶 | 2015 | 生物学杂志2015，32，3： | 0 |
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