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| 1 | 加强“将健康融入所有政策”的实施:基于现实主义的解释性案例研究显示文摘目前,世界各国普遍采取跨部门行动解决健康的宏观社会和经济决定因素。'将健康融入所有政策(Hi AP)'是各国采取跨部门行动的策略之一,它以广义的健康决定因素而非单纯的卫生服务为目标,在决策过程中系统解决健康问题。近几十年来出现了很多关于Hi AP的案例,但这些案例成功或失败的原因并未得到系统的研究,这就导致以证据为基础的有关促进或阻碍Hi AP策略实施的相关因素的研究较少。本文基于现实主义视角,采用解释性案例研究,分析了不同地区Hi AP策略的实施情况。本研究在提出概念性框架的基础上,分析了与Hi AP可持续实施有关的背景、社会机制及结果,并利用相关文献以及从关键知情人访谈中得到的证据,寻找相关的模式和主题对现象加以解释。最后,通过对瑞典和加拿大魁北克实施卫生影响力评估的情况进行比较,揭示了Hi AP成功实施的经验。此方法能够帮助研究者对某一地区内成功实施Hi AP的社会机制和背景因素的大量证据信息加以审核并做三角测量,还可用于分析其他形式的部门间行动,以减少不同背景、不同地区之间的卫生不公平性现象。 | Ketan Shankardass Emilie Renahy Carles Muntaner Patricia O’Campo | 2015 | 中国卫生政策研究2015，8，3： | 17 |
| 2 | Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis. | Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar | 2008 | World Journal of Gastroenterology2008，14，17： | 11 |
| 3 | Nitric oxide and cancer显示文摘Nitric oxide (NO) is a lipophilic,highly diffusible and short-lived physiological messenger which regulates a variety of important physiological responses including va sodilation,respiration,cell migration,immune resp onse and apoptosis.NO is synthesized by three differ entially gene-encoded NO synthase (NOS) in mammals: neuronal NOS (nNOS or NOS-1),inducible NOS (iNOS or NOS-2) and endothelial NOS (eNOS or NOS-3).All isof or ms of NOS catalyze the reaction of L-arginine,NA DPH and oxygen to NO,L-citrulline and NADP.NO may exert its cellular action by cGMP-dependent as well as by cGMP-independent pathways including postranslational modifications in cysteine (S-nitrosylation or S-nit rosation) and tyrosine (nitration) residues,mixed disulf ide formation (S-nitrosoglutathione or GSNO) or prom ot ing further oxidation protein stages which have been related to altered protein function and gene transcription,genotoxic lesions,alteration of cell-cycle check points,apoptosis and DNA repair.NO sensitizes tumor cells to chemotherapeutic compounds.The expression of NOS-2 and NOS-3 has been found to be increased ina variety of human cancers.The multiple actions of NO in the tumor environment is related to heterogeneous cell responses with particular attention in the regulation of the stress response mediated by the hypoxia inducible factor-1 and p53 generally leading to growth arrest,apoptosis or adaptation. | Jordi Muntané Manuel De la Mata | 2010 | World Journal of Hepatology2010，2，9： | 9 |
| 4 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 5 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 6 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 7 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 8 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 9 | TNF-alpha dependent production of inducible nitric oxide is involved in PGE1 protection against acute liver injury显示文摘 | Muntane J Rodriguez FJ Segado O | 2000 | Gut2000，47，4： | 1 |
| 10 | Efect of bl I iary drainage Oil plasma levels of endotoxin, cytokines, and C - reative protein in obstructive jatmdice 显示文摘 | Padillo FJ Muntane J Montem JL | 2002 | World Surg2002，26，： | 1 |
| 11 | The antithrombotic profile of aspririn resistance,or simply failure显示文摘 | Altman R Luciardi C Muntaner J | | 0，，： | 1 |
| 12 | Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease 显示文摘 | Muntane G Dalfo E Martlnez A | 2006 | Neuroehem2006，99，1： | 1 |
| 13 | Inframammary fold:a histologic reappraisal显示文摘 | Muntan CD Sundine MJ Rink RD | 2000 | Plast Reconstr Surg2000，105，2： | 1 |
| 14 | Predicting Early Mortality After Acute Variceal Hemorrhage Based on Classification and Regression Tree Analysis显示文摘 | Salvador Augustin Laura Muntaner José T. Altamirano Antonio González Esteban Saperas Joan Dot Monder Abu–Suboh Josep R. Armengol Joan R. Malagelada Rafael Esteban Jaime Guardia Joan Genescà | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 1 |
| 15 | Inframammary fold : a histologic reappraisal显示文摘 | Muntan C D Sundine M J Rink R D | 2000 | Plast Reconstr Surg2000，105，54： | 1 |
| 16 | Effect of PGE1 on TNF-alpha status and hepatic D-galactosamine-induced apoptosis in rats显示文摘 | Muntane J Montero JL Marchal T | 1998 | J Gastroenterol Hepatol1998，13，2： | 1 |
| 17 | Effect of PGE1 on TNF-alpha status and hepatic D-galactosamine-induced apoptosis in rats显示文摘 | MUNTANE J MONTERO JL MARCHAL T | 1998 | J Gastroenterol Hepatol1998，13，2： | 1 |
| 18 | Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimers disease, and in Parkinson disease and related alphasynucleinnopathies 显示文摘 | Muntane G Dalfo E Martinez A | 2008 | Neuroscience2008，152，4： | 1 |
| 19 | Efficacy assessment of meloxicam,a preferential cyclooxygenase-2 inhibitor,in acute coronary syndromes without ST-segment elevation:the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2(NUT-2) pilot study显示文摘 | Altman R Luciardi HL Muntaner J | 2002 | Circulation2002，106，2： | 1 |
| 20 | Radiologic features of Rhodococcus equi pneumonia in AIDS 显示文摘 | Muntaner L Leyes M Payeras A | 1997 | Eur J Radiol1997，24，1： | 1 |
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