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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | TNF-alpha dependent production of inducible nitric oxide is involved in PGE1 protection against acute liver injury显示文摘 | Muntane J Rodriguez FJ Segado O | 2000 | Gut2000，47，4： | 1 |
| 3 | Reactive oxygen and nitrogen species in the renal ischemia/reperfusion injury显示文摘 | Rodriguez F Bonacasa B Fenoy FJ | 2013 | Curr Pharm Des2013，19，15： | 1 |
| 4 | Scientific basis and current status of organ preservation 显示文摘 | Toledo-Pereyra LH Rodriguez FJ | 1994 | Transplant Proc1994，26，1： | 1 |
| 5 | Intratympanic gentamicin treatment for Miniere's disease显示文摘 | Mcefely WJ Singleton GT Rodriguez FJ | 1998 | Otolaryngol Head Neck Surg1998，118，5： | 1 |
| 6 | The spectrum of malignancy in craniopharyngioma 显示文摘 | Rodriguez FJ Scheithauer BW Tsunoda S | 2007 | Am J Surg Pathol2007，31，7： | 1 |
| 7 | Histopathologic grading of adult medulloblastomas显示文摘 | Rodriguez FJ Eberhart C O' Neill BP | 2007 | Cancer2007，109，12： | 1 |
| 8 | Significance of Lymph Node Metastases in Patients with Pancreatic Cancer Undergoing Curative Resection显示文摘 | Delcore R Rodriguez FJ Forster J | 1996 | Am J Surg1996，172，5： | 1 |
| 9 | Activated spinal cord ependymal stem cells rescue neurological function显示文摘 | Moreno MV Rodriguez Jimenez FJ Garcia RM | | 0，，： | 1 |
| 10 | Central neurocytoma: management recommendations based on a35-year experience 显示文摘 | LEENSTRA JL RODRIGUEZ FJ FRECHETTE CM | 2007 | Radiat Oncol Biol Phys2007，67，4： | 1 |
| 11 | E-cad-herin’s dark side: Possible role in tumor progression显示文摘 | Rodriguez FJ Lewis-Tuffin LJ Anastasiadis PZ | | 0，，01： | 1 |
| 12 | E-cadherin's dark side:Possible role in tumor progression显示文摘 | Rodriguez FJ Lewis-Tuffin LJ Anastasiadis PZ | | 0，，01： | 1 |
| 13 | A phase III, ran- domized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomato- toxic ehemotherapy显示文摘 | Giles FJ Rodriguez R Weisdorf D | 2004 | Leuk Res2004，28，6： | 1 |
| 14 | Pulmonary ehondroma:a tumor associated with Carney triad and different from pulmonary hamartoma 显示文摘 | Rodriguez FJ Aubry MC Tazelaar HD | 2007 | Am J Surg Pathol2007，31，12： | 1 |
| 15 | Non- convulsive statue associated with eplcptieus in patients with rehalfailue显示文摘 | Martinez Rodriguez JE Barfiga FJ Santamada J | 2001 | AmJ Med2001，111，1： | 1 |
| 16 | Gn - RH antagonists in intrauterine insemination : the weekend - free protocol显示文摘 | Matorras R Ramon O Exposito A Corcostegui B Ocerin I Gonzalez - Lopera S Rodriguez - Escudero FJ | 2006 | J Assist Reprod Genet2006，22，： | 1 |
| 17 | The spectrum of malignancy in craniopharyngioma显示文摘 | Rodriguez FJ Scheithauer BW Tsunoda S | 2007 | Am J Surg Pathol2007，31，7： | 1 |
| 18 | ERCP in patients 90 years of age and older显示文摘 | Rodriguez - Gonzilez FJ Naranjo - Rodriguez A Mata - Tapia I | 2003 | Gastrointest Endosc2003，58，2： | 1 |
| 19 | MDCT angiography for detection and quantification of small intracranial arteries: comparison with conventiona! catheter angiography显示文摘 | Villablanca JP Rodriguez FJ Stockman T | 2007 | AJR Am Jroentgen-ol2007，188，2： | 1 |
| 20 | Ischemiaireperfu sion injury and its consequences on immunity and inflammation显示文摘 | Slegtenhorst BR Dor FJ Rodriguez H | 2014 | Curt Transplant Rep2014，1，3： | 1 |
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