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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Choledochal cysts: Similarities and differences between Asian and Western countries显示文摘Choledochal cysts(CCs)are rare bile duct dilatations,intra-and/or extrahepatic,and have higher prevalence in the Asian population compared to Western populations.Most of the current literature on CC disease originates from Asia where these entities are most prevalent.They are thought to arise from an anomalous pancreaticobiliary junction,which are congenital anomalies between pancreatic and bile ducts.Some similarities in presentation between Eastern and Western patients exist such as female predominance,however,contemporary studies suggest that Asian patients may be more symptomatic on presentation.Even though CC disease presents with an increased malignant risk reported to be more than 10%after the second decade of life in Asian patients,this risk may be overstated in Western populations.Despite this difference in cancer risk,management guidelines for all patients with CC are based predominantly on observations reported from Asia where it is recommended that all CCs should be excised out of concern for the presence or development of biliary tract cancer. | George N Baison Morgan M Bonds William S Helton Richard A Kozarek | 2019 | World Journal of Gastroenterology2019，25，26： | 16 |
| 3 | Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: A systematic review and meta-analysis显示文摘BACKGROUND With the increasing complexity of surgical interventions performed in orthopaedic trauma surgery and the improving technologies used in threedimensional(3D)printing,there has been an increased interest in the concept.It has been shown that 3D models allow surgeons to better visualise anatomy,aid in planning and performing complex surgery.It is however not clear how best to utilise the technique and whether this results in better outcomes.AIM To evaluate the effect of 3D printing used in pre-operative planning in orthopaedic trauma surgery on clinical outcomes.METHODS We performed a comprehensive systematic review of the literature and a metaanalysis.Medline,Ovid and Embase were searched from inception to February 8,2018.Randomised controlled trials,case-control studies,cohort studies and case series of five patients or more were included across any area of orthopaedic trauma.The primary outcomes were operation time,intra-operative blood loss and fluoroscopy used.RESULTS Seventeen studies(922 patients)met our inclusion criteria and were reviewed.The use of 3D printing across all specialties in orthopaedic trauma surgery demonstrated an overall reduction in operation time of 19.85%[95%confidence intervals(CI):(-22.99,-16.71)],intra-operative blood loss of 25.73%[95%CI:(-31.07,-20.40)],and number of times fluoroscopy was used by 23.80%[95%CI:(-38.49,-9.10)].CONCLUSION Our results suggest that the use of 3D printing in pre-operative planning in orthopaedic trauma reduces operative time,intraoperative blood loss and the number of times fluoroscopy is used. | Catrin Morgan Chetan Khatri Sammy A Hanna Hutan Ashrafian Khaled M Sarraf | 2020 | World Journal of Orthopedics2020，11，1： | 7 |
| 4 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 5 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 6 | Endoscopic Retrograde Cholangiopancreatography Gut Perforations: When to Wait! When to Operate!显示文摘 | Morgan Katherine A Fontenot Bennett B Ruddy Jean M Mickey Suzanne Adams David B | 2009 | The American Surgeon2009，，6： | 2 |
| 7 | 葡糖胺和半乳糖胺的测定显示文摘定量测定葡糖胺和半乳糖胺的分析操作已由Elson和Morgan(1933)报道[1]。这一方法基于Pauly和Ludwig(1922)的发现,即在100℃的碱性溶液中氨基糖与乙酰丙酮反应形成一生色物质,这一物质经对二甲氨基苯甲醛酸性乙醇溶液处理产生一个或多个发色团。光电分光光度计的开发和应用很大程度上提高了技术灵敏度和准确度,虽然已报道了很多此方法的改良设计操作。 | Rondle C J M Morgan W T J 陈祥娥 | 2010 | 食品与药品2010，12，11： | 2 |
| 8 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 9 | Osmoregulation and Water Stress in Higher Plants显示文摘 | J M Morgan | 1984 | Annual Review of Plant Physiology1984，，： | 2 |
| 10 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 11 | The commitment-trust theory of relationship marketing 显示文摘 | MORGAN R M HUNT S D | 1994 | Journal of Marketing1994，58，3： | 1 |
| 12 | Chromosomal location of a wheat osmoregulation gene using RFLP analysis显示文摘 | MORGAN J M TAN M K | 1996 | Aust J Plant Physiol1996，23，： | 1 |
| 13 | Asset and Liability Management Systemfor Towers Perrin-Tillinghast显示文摘 | Gould G Morgan C | 2000 | Interfaces2000，30，1： | 1 |
| 14 | The Commitment-Trust Theory of Relationship Marketing显示文摘 | HUNT D S | 1994 | Journal of Marketing Research1994，58，： | 1 |
| 15 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 16 | The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism 显示文摘 | Wogulis M Morgan T Ishida Y | 2006 | Biochem Biophys Res Commun2006，339，1： | 1 |
| 17 | Evaluation of the ergogenic properties of ginseng:an update显示文摘 | Bahrke M S Morgan W R | 2000 | Sports Med2000，29，2： | 1 |
| 18 | Compucations of surgery for arteriovenous maiformation of the brain显示文摘 | Morgan M K Johnston I H Haulan J M | 1993 | J Neurosurg1993，78，： | 1 |
| 19 | Elective stenting of symptomatic middle cerebral artery stenosis显示文摘 | Gomez CR Misra VK Morgan M | 2000 | AJNR2000，21，： | 1 |
| 20 | Genetic improvement in the yield of winter:afurther evaluation 显示文摘 | AUSTIN R B FORD M A MORGAN C L | 1989 | J Agric Sci1989，112，： | 1 |
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