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| 1 | 甘肃大地湾遗址距今6万年来的考古记录与旱作农业起源显示文摘报道了中国北方早期旱作农业起源地之一的甘肃秦安大地湾遗址Dadiwan06探方的最新发掘成果,根据黄土-古土壤序列、绝对测年(AMS 14C和光释光测年)、气候事件年龄和考古分析,为Dadiwan06探方的地层沉积建立了6.5万年的年代框架.考古材料分析显示,Dadiwan06探方完整记录了石英打制技术制品、细石器技术制品、大地湾一期文化以及仰韶文化陶器制品等分别代表中国北方原始采集狩猎经济、先进采集狩猎经济、早期栽培经济与成熟农业经济的4个不同发展阶段,反映了大地湾遗址距今6.0万年以来由采集狩猎经济逐步向农业经济过渡的持续人类活动历史。 | 张东菊 陈发度 BETTINGER R L BARTON L 吉笃学 MORGAN C 王辉 程晓钟 董广辉 GUILDERSON T P 赵晖 | 2010 | 科学通报2010，55，10： | 42 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Mouse embryos cloned from brain tumors显示文摘Cancer cells escape from growth cont rol by accumulating genetic and epig enetic alterations.In rare instances,epigenetic changes alone are oncogenic.Furthermore,a gents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations.How ever,it is unclear to what extent epi genetic reprogramming can reverse o ncogenesis.Using somatic nuclear transfer,we show that medul loblastomas arising in Ptc1+/-mice can direct preimplantation develop ment.Additionally,blastocysts derived from medullobl astoma nuclei form postimplantatio n embryos with typical cell layers.T hus,tumor cells can be epigenetically reprogrammed into n ormal cell types.This approach coul d lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis. | Li L Connelly MC Wetmore C Curran T Morgan JI | 2003 | 癌症2003，22，7： | 11 |
| 4 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 5 | Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices显示文摘AIM: To study the institutional experience over 8 years with 200 continuous-flow(CF)- left ventricular assist devices(LVAD).METHODS: We evaluated our institution's LVAD database and analyzed all patients who received a CF LVAD as a bridge to transplant(BTT) or destination therapy from March 2006 until June 2014. We identified 200 patients, of which 179 were implanted with a Heart Mate II device(Thoratec Corp., Pleasanton, CA) and 21 received a Heartware HVAD(Heart Ware Inc., Framingham, MA).RESULTS: The mean age of our LVAD recipients was 59.3 years(range 17-81), 76%(152/200) were males, and 49% were implanted for the indication of BTT. The survival rate for our LVAD patients at 30 d, 6 mo, 12 mo, 2 years, 3 years, and 4 years was 94%, 86%, 78%, 71%, 62% and 45% respectively. The mean duration of LVAD support was 581 d(range 2-2595 d). Gastrointestinal bleeding(was the most common adverse event(43/200, 21%), followed by right ventricular failure(38/200, 19%), stroke(31/200, 15%), re exploration for bleeding(31/200, 15%),ventilator dependent respiratory failure(19/200, 9%) and pneumonia(15/200, 7%). Our driveline infection rate was 7%. Pump thrombosis occurred in 6% of patients. Device exchanged was needed in 6% of patients. On multivariate analysis, preoperative liver dysfunction, ventilator dependent respiratory failure, tracheostomy and right ventricular failure requiring right ventricular assist device support were significant predictors of post LVAD survival.CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. | Athanasios Tsiouris Gaetano Paone Hassan W Nemeh Jamil Borgi Celeste T Williams David E Lanfear Jeffrey A Morgan | 2015 | World Journal of Cardiology2015，7，11： | 5 |
| 6 | 葡糖胺和半乳糖胺的测定显示文摘定量测定葡糖胺和半乳糖胺的分析操作已由Elson和Morgan(1933)报道[1]。这一方法基于Pauly和Ludwig(1922)的发现,即在100℃的碱性溶液中氨基糖与乙酰丙酮反应形成一生色物质,这一物质经对二甲氨基苯甲醛酸性乙醇溶液处理产生一个或多个发色团。光电分光光度计的开发和应用很大程度上提高了技术灵敏度和准确度,虽然已报道了很多此方法的改良设计操作。 | Rondle C J M Morgan W T J 陈祥娥 | 2010 | 食品与药品2010，12，11： | 2 |
| 7 | 比色法测定N-乙酰葡糖胺和N-乙酰半乳糖胺显示文摘乙酰葡糖胺与对二甲氨基苯甲醛的反应最初由Müller发现,即当戊-乙酰葡糖胺溶液与稀氢氧化钾共热后,加入盐酸酸化的对二甲氨基苯甲醛溶液(Ehrlich试剂)可产生强紫红色。 | Morgan W T J Elson L A 陈祥娥 | 2010 | 食品与药品2010，12，9： | 2 |
| 8 | 原发性高血压与钾和镁显示文摘本文介绍钾、镁与高血压的关系,阐述高钾、高镁饮食对高血压病人的重要性,并强调高血压病人应用利尿剂等治疗期间防治钾、镁缺乏的意义及纠正的方法。 | Morgan T 任建民 | 1993 | 国外医学(老年医学分册)1993，14，3： | 2 |
| 9 | The European soil erosion model (EUROSEM) : A dynamic approach for predicting sediment transport from fields and small catch ments 显示文摘 | Morgan R P C Quinton T N Smith R E | 1998 | Earth Surface Processes and Land forms1998，23，： | 1 |
| 10 | Radiation protection during percutaneous nephrolithotomy:a new urologic surgery radiation shield 显示文摘 | YANG RM MORGAN T BELLMAN GC | 2002 | J Endourol2002，16，10： | 1 |
| 11 | The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism 显示文摘 | Wogulis M Morgan T Ishida Y | 2006 | Biochem Biophys Res Commun2006，339，1： | 1 |
| 12 | A restrospective review of treatment of the odontogenic cyst显示文摘 | MORGAN T A BURTON C C QIAN F | 2005 | Br J Oral Mazillofac Surg2005，63，5： | 1 |
| 13 | Primary instability of lumbar vertebrae as a common cause of low back pain显示文摘 | Morgan FP King T | 1957 | J Bone Joint Surg Brt1957，39，： | 1 |
| 14 | The crystal structure of an odorant binding protein from Anopheles gambiae : Evidence for a common ligand release mechanism显示文摘 | Wogulis M Morgan T Ishida Y | 2006 | Biochemical and Bio- physical Research Communications2006，339，： | 1 |
| 15 | The effect of presentation and mode of delivery on neonatal outcome in the second twin显示文摘 | Greig PC Veille JC Morgan T | 1992 | Am J Obstet Gynecol1992，167，4： | 1 |
| 16 | Molecularly imprintedpolymer sensor arrays显示文摘 | Greene N T Morgan S L Shimizu K D | 2004 | Chemical Communications2004，，10： | 1 |
| 17 | Proto-oncogene transcription factors and pilepsy显示文摘 | Morgan JI Gurran T | 1991 | Trends Pharmacol Sci1991，12，9： | 1 |
| 18 | Renin,angiotensin,sodium and organ damage显示文摘 | | 2003 | Hypertens Res2003，26，5： | 1 |
| 19 | Conversion of triglycerides to hydrocarbons over supported metal catalysts 显示文摘 | MORGAN T GRUBB D SANTILLAN-JIMENEZ E CROCKER M | 2010 | Top Catal2010，53，1112： | 1 |
| 20 | Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis显示文摘 | Jenkins ZA van Kogelenberg M Morgan T | 2009 | Nature Genetics2009，41，1： | 1 |
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