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| 1 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 2 | 生态学的时空特性(英文)显示文摘众所周知 ,几乎所有的生态学特征和现象都受限于一定的时间和空间。因此 ,相应的科学假设和相关的生态学结论也只能基于这些特定的时空尺度范围。我们利用颇为熟知的事例 ,引用生态学文献中的具体实例 ,提纲挈领地论述了时空在生态学研究中的重要性。这些实例包括我们在长白山对云、冷杉 (Piceajezoensis,Abiesnephrolepis)林林冠结构的模拟、在北美应用遥感和气象方法对碳通量的估算 ,以及测定湿地生态系统对加温的反应等。文中所涉及的所有生态学现象 ,对时间和空间都有强烈的依赖性。因而 ,从生态学问题的提出 ,到科学假设的演绎 ,以至试验设计和综合数据分析 ,都必须以时、空为前提 ,才不至于导致荒谬结论。 | James M.LE MOINE 陈吉泉 | 2003 | 植物生态学报2003，27，1： | 6 |
| 3 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 4 | Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract显示文摘 | Rogier P. Voermans Olivier Le Moine Daniel von Renteln Thierry Ponchon Marc Giovannini Marco Bruno Bas Weusten Stefan Seewald Guido Costamagna Pierre Deprez Paul Fockens | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 2 |
| 5 | New developments in steroid-resistant nephrotic syndrome显示文摘 | Moin A. Saleem | 2013 | Pediatric Nephrology2013，，5： | 2 |
| 6 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 7 | Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function显示文摘 | P Van der Linden O Le Moine M Ghysels M Ortinez J Deviere | 1996 | Hepatology1996，，5： | 2 |
| 8 | A further study of numerical errors in large-eddy simulations显示文摘 | Chow F K Moin P | 2003 | Journal of Computational Physics2003，184，2： | 1 |
| 9 | Direct simulations of turbulent flow using finite difference schemes显示文摘 | Moin P | 1991 | Sei Comput1991，，1： | 1 |
| 10 | Pericellular cathepsin B and malignant progression显示文摘 | Sloane BF Moin K | 2003 | Cancer Metastasis Rev2003，22，23： | 1 |
| 11 | Prevalence and awareness of melasrnn dur-ing pregnancy显示文摘 | Moin A Jabery Z Fallah N | 2006 | Int J Dermatol2006，45，3： | 1 |
| 12 | Numerical Investigation of Turbulent Channel Flow显示文摘 | Moin P Kim J | 1982 | Journal of Fluid Mechanics1982，118，： | 1 |
| 13 | Site preference of fish myxosporeans in thegill 显示文摘 | Moin ar K | 2002 | Diseases of Aquatic Organisms2002，48，3： | 1 |
| 14 | Active control of flow separation over an airfoil using synthetic jets显示文摘 | You D Moin P | 2008 | J Fluid Struct2008，24，8： | 1 |
| 15 | Progress in large eddy simulation of turbulence flows显示文摘 | Moin P | 1997 | AIAA Journal1997，38，2： | 1 |
| 16 | Active control of flow separation over an airfoil using synthetic jets 显示文摘 | You D Moin P | 2008 | Journal of Fluids and Structures2008，24，8： | 1 |
| 17 | The effects of air pollution on structures,proteins and allergenicity of pollen grains显示文摘 | Chehregani A Moin M | 2004 | Aerobiologia2004，20，： | 1 |
| 18 | Removal of Copper-Based Catalyst in Atom Transfer Radical Polymerization Using Different Extraction Techniques 显示文摘 | Ydens I Moins S Botteman F | 2004 | e-Polym2004，39，： | 1 |
| 19 | Modulation of liver injury by interleukin-10 显示文摘 | Louis H Le Moine O Goldman M | 2003 | Acta Gastroenterol Belg2003，66，1： | 1 |
| 20 | NF - kappa B regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome 显示文摘 | Moine P Mclntyre R Schwartz MD | 2000 | Shock2000，13，2： | 1 |
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