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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 3 | Comparative induction of controlled circulation by magnesium and remifentanil in spine surgery显示文摘AIM: To evaluate the efficacy of magnesium sulfate(MGS) in comparison with remifentanil for induction of relative hypotension in posterior fusion of spine(PSF).METHODS: In this randomized clinical trial, 40 patients with the American Society of Anesthesiologists Ⅰ and Ⅱ physical status undergoing lumbar PSF were randomized to receive remifentanil(REM) 0.15 μg/kg or MGS 50 mg/kg for controlled hypotension. The administering anesthesiologist was blinded to the medication. Continuous infusion was maintained at a fixed volume rate to deliver precalculated doses of either study drugs. All other aspects of anesthesia and surgery were similar in the two groups. The target mean arterial pressure(MAP) range used in this study was 60-70 mm Hg. In the course of surgery, the hemodynamic variables, volumeof blood loss, urine output, fluid intake and surgeon's satisfaction were recorded. Data was analyzed with SPSS version 13.0 and P values less than 0.05 were considered significant.RESULTS: Twenty patients in the MGS group and 19 patients in the REM group were studied. There was no difference between the two groups in the hemodynamic variables, blood loss, urine output, fluid requirement and surgeon's satisfaction for exposure. The target MAP was achieved in 75% of Mg and 58% of remifentanil groups. Although a higher number of patients in the REM group required nitroglycerin(42.1%) to reach the target MAP than those in the MGS group(25%), this difference was not statistically significant(P = 0.32).CONCLUSION: Our findings showed that in patients undergoing lumbar PSF surgery, remifentanil and MGS have a similar hypotensive effect and comparable amount of blood loss without any significant adverse effects. | Mohammad R Ghodraty Mohammad M Homaee Kourosh Farazmehr Ali R Nikzad-Jamnani Masoud Soleymani-Dodaran Ali R Pournajafian Nader D Nader | 2014 | World Journal of Orthopedics2014，5，1： | 3 |
| 4 | Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis显示文摘 | Patricia Jabre Véronique L. Roger Mohammad H. Murad Alanna M. Chamberlain Larry Prokop Frédéric Adnet Xavier Jouven | 2011 | Circulation2011，，15： | 2 |
| 5 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 6 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 7 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 8 | Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute is-chemic stroke显示文摘 | Christoforidis GA Mohammad Y Kehagias D | 2005 | AJNR Am J Neuroradiol2005，26，7： | 1 |
| 9 | Comparison of Before and After Varicocelectomy Levels of Nitric Oxide in Seminal Fluid of Infertile Men显示文摘 | Hossein K Alireza D Mohammad A | 2012 | Nephrourol Mon2012，4，4： | 1 |
| 10 | Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children 显示文摘 | Mehrotra D Pradhan R Mohammad S | 2008 | Brit J Oral Macitlofac Surg2008，46，： | 1 |
| 11 | Performancesimulation of a four-stroke engine with variablestroke-length and compression ratio 显示文摘 | JEHAD A Y MOHAMMAD H D | 2004 | Applied Energy2004，77，： | 1 |
| 12 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 13 | TGF - 13 - RI kinase inhibitor SD - 208 reduces the development and progression of melanoma bone metastases 显示文摘 | Mohammad K S Javelaud D Fournier P G | 2011 | Cancer Research2011，71，1： | 1 |
| 14 | Angiographic assessment of pial collateralsas a prognostic indicator following in- tra-arterial thrombolysis for acute ischemic stroke 显示文摘 | Christotoridis G A Mohammad Y Kehagias D | 2005 | AJNR Am J Neuroradio12005，26，7： | 1 |
| 15 | Tuning DOS measuring parameters based on double-loop EPR in H2SO4 containing KSCN by taguchi method显示文摘 | MOJTABA M MOHAMMAD H M ALI D | 2010 | Corrosion Science2010，52，： | 1 |
| 16 | Enantioselective Total Synthesis of(-)-Acylfulvene and(-)-Irofulven显示文摘 | Mohammad M Piizzi G Siegel D S | 2006 | AngewChem Int Ed2006，45，： | 1 |
| 17 | Antimi- c~bial and pilling evaluation of the modified cellulosic fabrics using polyurethane acrylate copolymers 显示文摘 | Shazia Tabasuma Mohammad Zuber Tahir Jamilb et d | 2013 | International Journal of Biological Macromolecules2013，56，： | 1 |
| 18 | Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandihular ankylosis in children 显示文摘 | Mehrotra D Pradhan R Mohammad S | 2008 | Brit J OralMaxillofacSurg2008，46，7： | 1 |
| 19 | The relation between in situ and laboratory rock properties used in numerical modeling显示文摘 | MOHAMMAD N REDDISH D J STACE L R | 1997 | Interna- tional Journal of Rock Mechanics : Mining Sci- ences1997，34，2： | 1 |
| 20 | Germination behavior of some halophytesin Indian desert显示文摘 | Mohammad S Sen D N | 1990 | Int J Exp Biol1990，28，： | 1 |
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