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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | 农产品电子商务系统中收购模块的设计与实现显示文摘为了满足农产品电子商务系统中分散货源的集中管理功能,本研究对系统的需求进行了分析,确定了农产品收购模块的主要功能。根据系统的功能需求分析,明确了收购模块的流程,配合数据库设计方法,给出了收购信息的实体-属性。在Apache服务器环境下,采用B/S架构、PHP技术、MySQL数据库实现了系统的运行。结果表明本研究所设计的农产品电子商务系统中收购模块的功能和性能测试结果较好,能够为电子商务系统中收购模块的设计和实现提供有益参考。 | 王双 朱莹泽 Mischelle Esguerra | 2021 | 科学技术创新2021，，24： | 2 |
| 4 | A cognitive-affective system theory of personality: re-conceptualizing sit-ation, dispositions, dynamics, and invariance in personality structure显示文摘 | Mischel W Shoda Y | 1995 | Psychological review1995，，102： | 1 |
| 5 | Neonatal seizures: muhicenter variability in current treatment practices显示文摘 | Bartha AI Shen J Katz KH Mischel RE Yap KR lvacko JA | 2007 | Pediatr Neurol2007，37，2： | 1 |
| 6 | A Hot/cool-system Analysis of Delay of Gratification:Dynamics of Willpower显示文摘 | Metcalfe J Mischel W | 1999 | Psychology Review1999，，106： | 1 |
| 7 | Listen while you work? Quasi-experimental rela- tions between personal-stereo headset use and em- ployee work responses显示文摘 | Oldham G R Cummings A Mischel L J | 1995 | Journal of Applied Psy- chology1995，80，5： | 1 |
| 8 | Traits as prototypes: effects on recognition memory显示文摘 | Cantora N Mischel W | 1977 | Journal of Personality and So- cial Psychology1977，35，1： | 1 |
| 9 | Molecular classi-fication of gliomas显示文摘 | MASUI K MISCHEL PS REIFENBERGER G | 2016 | Handb Clin Neurol2016，134，： | 1 |
| 10 | A hot/cool-system analysis of delay of gratification: Dynamics of willpower显示文摘 | Mischel W | 1999 | Psychological Review1999，106，： | 1 |
| 11 | A cognitive-affective system theory of personality:reconceptualizing situations,dispositions,dynamics,and invariance in personality structure显示文摘 | Mischel W Shoda Y | 1995 | Psychological Review1995，102，2： | 1 |
| 12 | Instrumental Ideation in Delay of Gratification 显示文摘 | MISCHEL W UNDERWOOD B | 1974 | Child Development1974，45，6： | 1 |
| 13 | A cognitive-affective system theory of personality: Reconceptualizing situations, dispositions, dynamics, & invariance in personality structure显示文摘 | Mischel W Shoda Y | 1995 | Psychological Review1995，102，： | 1 |
| 14 | A cognitive-affective system theory of situations, disposition,dynamics and invariance in personality structure显示文摘 | Mischel W Shoda Y | 1995 | Psychological R eview1995，102，2： | 1 |
| 15 | Toward a cognitive social learning reconcep- tualization of personality 显示文摘 | Mischel W | 1973 | Psychological Review1973，80，4： | 1 |
| 16 | Implications of person-situation interaction : getting over the field' s borderline personality disorder显示文摘 | Mischel W | 1999 | European Journal of Personality1999，，13： | 1 |
| 17 | Targeted molecular therapy of GBM显示文摘 | Mischel PS Cloughesy TF | 2003 | Brain Pathol2003，13，： | 1 |
| 18 | A hot/cool-system analysis of delay of gratification:Dynamics of willpower显示文摘 | METCALFE J MISCHEL W | 1999 | Psychol Rev1999，106，1： | 1 |
| 19 | The nature of adolescent competencies predicted by preschool delay of gratification显示文摘 | MISCHEL W SHODA Y PEAKE P K | 1998 | Journal of Personality and social Psychology1998，，54： | 1 |
| 20 | A hot/cool-system analysis of gratifica- tion: dynamics of willpower 显示文摘 | Metcafe J Mischel W | 1999 | Psychological Review1999，106，1： | 1 |
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