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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Influence of precipitation on the Portevin-Le Chatelier effect in Al-Mg alloys显示文摘In the alloy with solute content higher than the limiting solubility,the solute atoms that have failed to dissolve will precipitate from the solid solution and form precipitations.In this study, the Portevin-Le Chatelier(PLC) effects in annealed 5456 and 5052 aluminum alloys with different precipitation contents have been investigated under different applied strain rates.The results suggest that precipitations have significant effect on the PLC effect and the more the precipitations are, the greater the ... | Qi Hu,~(a))Qingchuan Zhang,~(b)) Shihua Fu,Pengtao Cao,and Ming Gong CAS Key Laboratory of Mechanical Behavior and Design of Materials,University of Science and Technology of China,Hefei 230027,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，1： | 3 |
| 3 | ^(99m)Tc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging显示文摘The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.In this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with ^(99m)Tc.^(99m)Tc-AMD3100 was verified by thin layer radio chromatography(TLRC).The tumor-localizing properties of ^(99m)Tc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.^(99m)Tc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors. | Jin Ming Zhang~(a,),Jia He Tian~a,Tian Ran Li~a, Hai Yu Guo~a,Li Shen~b a Department of Nuclear Medicine,The PLA General Hospital,Beijing,100853,China b Peking University Health Science Center,Beijing,100191,China | 2010 | Chinese Chemical Letters2010，21，4： | 3 |
| 4 | A novel method for Co(Ⅱ) and Cu(Ⅱ) analysis by capillary electrophoresis with chemiluminescence detection显示文摘Based on the fact that some metal ions can catalyze the chemiluminescence(CL)reaction of luminol with K3Fe(CN)6,a novel capillary electrophoresis CL method was developed for the determination of Co(Ⅱ)and Cu(Ⅱ).The separation was carried out with a 10 mmol/L sodium acetate solution containing 0.8 mmol/L luminol and 2.0 mmol/Lα-HIBA(adjusted to pH 4.8 by HAc solution).The post-capillary reagent was 2.0 mmol/L K3Fe(CN)6 which was adjusted to pH 13.0 by NaOH solution.Under the optimum conditions,the detection limits(S/N=3)for Co(Ⅱ)and Cu(Ⅱ)were 7.5×10-11mol/L and 7.5×10-9mol/L,with the linear range of 7.5×10-9mol/L to 1.0×10-6mol/L and 7.5×10-8mol/L to 5.0×10-5mol/L, respectively. | Xiao Ming Guo~a Xiang Dong Xu~(a,b) Hui Jing Zhang~a Yong Gang Hu~(a,*) Jie Zhang~a a Institute of Environmental Science & Engineering,Huazhong University of Science and Technology,Wuhan 430074,China b Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074,China | 2007 | Chinese Chemical Letters2007，18，9： | 3 |
| 5 | Synthesis and bioactivity of novel 3-(1-hydroxyethylidene)-5-substituted-pyrrolidine-2,4-dione derivatives显示文摘3-(1-hydroxyethylidene ) 的十新奇 5 代用品衍生物 pyrrolidine-2,4-dione 被综合。混合物被红外, 1H NMR, MS 和元素的分析证实。生物鉴定分别地显示这些混合物显示出显著 herbicidal 活动,并且混合物 6f 和 6j 对 Echinochloa crusgalli 的梗展出了优秀禁止的活动,与 94.4 和 72.7 mg/L 的 EC50 价值。 | B ao Feng Han Qing Ming Shi Xian Feng Wang Jian Bo Liu Sheng Qiang Chun Long Yang | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 6 | DC Reactive Sputter Deposition of ZnO:Al Thin Film on Glass显示文摘 | Ting Jyh Ming Tsai B S | 2001 | Materials Chemistry and Physics2001，72，： | 1 |
| 7 | Quasi-phase-matched third-harmonic generation in a quasi-perlodic optical superlattice显示文摘 | ZHU S N ZHU Y Y MING N B | 1997 | Science1997，278，5339： | 1 |
| 8 | Increase in hypotonic stress- induced endocytic activity in macrophages via C1C-3 显示文摘 | Yan Y Ding Y Ming B | 2014 | Mol Cells2014，37，5： | 1 |
| 9 | Damage assessment and maintenance strategy of hydrogen re{ormer furnace tubes显示文摘 | GONG Jian ming TU Shang tung YOON K B | 1999 | Engineering Failure Analysis1999，6，： | 1 |
| 10 | Estimation of regional net primary productivity (NPP) using a process-based ecosystem model: How important is the accuracy of climate data? 显示文摘 | Matsushita B XU Ming CHEN Jingming | 2004 | Ecological Modelling2004，178，： | 1 |
| 11 | Applications of stalagmite laminae to paleoclimate reconstructions:Comparison with dendrochronology/climatology 显示文摘 | Tan Ming Baker A Gentry D Smith C Esper J Cai B G | 2006 | Quater Sci Rev2006，25，1718： | 1 |
| 12 | cAMP-dependent growth cone guidance by netrin-1显示文摘 | Ming GL Song HJ Berninger B | 1997 | Neuron1997，19，6： | 1 |
| 13 | Two-step SSCF to convert AFEX-treated switchgrass to ethanol using commercial enzymes and Saccharomyces Cerevisiae 424A(LNH-ST)显示文摘 | Jin MJ Ming W Venkatesh B | 2010 | Bioresource Technology2010，101，21： | 1 |
| 14 | Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro显示文摘 | Ma H P Ming L G Ge B F | 2011 | Journal of cellular biochemistry2011，112，3： | 1 |
| 15 | 2D-LDA: a statistical linear dis- criminant analysis for image matrix 显示文摘 | MING L YUAN B | 2005 | Pattern Recog- nition Letter2005，26，5： | 1 |
| 16 | AdaBoost-based face detection for embedded systems 显示文摘 | YANG Ming CRENSHAW J AUGUSTINE B MAREACHEN R Wu Ying | 2010 | Computer Vision and Image Understanding2010，114，11： | 1 |
| 17 | Near - infraredreflectance spectroscopy analysis of phosphorus in sugarcaneleaves显示文摘 | Chen Ming Glaz B Gilbert R A | 2002 | Agronomy Joumal2002，94，： | 1 |
| 18 | Treatment of the early-stage glottic cancer using low-temperature ra- diofrequency coblation显示文摘 | LIU B CHENG L MING H | 2016 | J Cancer Res Ther2016，12，： | 1 |
| 19 | Isola-ted thunderclap headache during sex: Orgasmic headache or re- versible cerebral vasoconstriction syndrome? Case Reports显示文摘 | Chih-- Ming Hua Ya--Ju Lin a Yang--Kai Fan b | 2010 | J Clin Neuro Sci2010，17，10： | 1 |
| 20 | Alaptive image segmentation using a genetic algorithm 显示文摘 | Bhanu B Lee S Ming J | 1995 | IEEE Trans System Man Crbernetics1995，5，12： | 1 |
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