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| 1 | Mid-infrared dual-comb spectroscopy with electro-optic modulators显示文摘Absorption spectroscopy of fundamental ro-vibrational transitions in the mid-infrared region provides a powerful tool for studying the structure and dynamics of molecules in the gas phase and for sensitive and quantitative gas sensing.Laser frequency combs permit novel approaches to perform broadband molecular spectroscopy.Multiplex dual-comb spectroscopy without moving parts can achieve particularly high speed,sensitivity and resolution.However,achieving Doppler-limited resolution in the mid-infrared still requires overcoming instrumental challenges.Here we demonstrate a new approach based on difference-frequency generation of frequency-agile near-infrared frequency combs that are produced using electro-optic modulators.The combs have a remarkably flat intensity distribution,and their positions and line spacings can be freely selected by simply dialing a knob.Using the proposed technique,we record,in the 3-μm region,Doppler-limited absorption spectra with resolved comb lines within milliseconds,and precise molecular line parameters are retrieved.Our technique holds promise for fast and sensitive time-resolved studies of,for example,trace gases. | Ming Yan Pei-Ling Luo Kana Iwakuni Guy Millot Theodor W Hänsch Nathalie Picqué | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 2 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 3 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 4 | Blind deblurring of spiral CT images 显示文摘 | Jiang Ming Wang Ge Margaret W | 2003 | IEEE Transactions on Medical Imaging2003，22，7： | 1 |
| 5 | Laboratory-simulated acid-sulfate weathering of basaltic materials:implications for formation of sulfates at meridiani planum and gusev crater,mars显示文摘 | Golden D C Douglas Ming W Richard Morris V | 2005 | Journal of Geophysical Research E Planets2005，110，12： | 1 |
| 6 | et al Superhydrophobic films from raspberry like particles显示文摘 | Ming W Wu D van Benthem R | 2005 | Nanoletters2005，，5： | 1 |
| 7 | Use of flow injection hydride generation technique in non-dispersive atomic fluorescence spectrometry显示文摘 | GUO Tie zheng LIU Ming zhong SCHRADER W | 1992 | J Anal At Spectrom1992，7，： | 1 |
| 8 | Design and optimi- zation of spherical lens antennas including practical feed models 显示文摘 | Huang Ming Yang S Xiong W | 2011 | Progress In Electromagnetics Research2011，120，： | 1 |
| 9 | Control of Charge Densities for Cationic Latex Particles显示文摘 | Voorn D J Ming W Herk A M van | 2005 | Macromolecules2005，38，： | 1 |
| 10 | Low surface energy polymeric films from novel fluorinated blocked isocyanates显示文摘 | Van Ravenstein L Ming W Van De Grampel R D | 2004 | Macromolecules2004，37，2： | 1 |
| 11 | Nutrient-substituted hydroxyapatites synthesis and characterization 显示文摘 | Golden D C Ming D W | 1999 | Journal of the Soil Science Society of America1999，63，2： | 1 |
| 12 | Two new coumarin bio- sides from Angelica dahurica 显示文摘 | Xiao D J Xing Z Z Ming W | 2008 | Chemistry of Natural Compounds2008，44，6： | 1 |
| 13 | Spl and p73 activate PUMA following serum starvation 显示文摘 | Ming L Sakaida T Yue W | 2008 | Carcinogenesis2008，29，10： | 1 |
| 14 | Biomimetic superhydrophobic and highly oleophobic cotton textiles显示文摘 | Hoefnagels H F Wu D De With G Ming W | 2007 | Langmuir2007，23，13： | 1 |
| 15 | Doping-dependent phase diagram of LaOMAs (M = V - Cu) and electron-type superconductivity near ferromagnetic instability 显示文摘 | Xu G Ming W Yao Y Dai X Zhang S C Fang Z | 2008 | Europhysics Lett2008，82，67： | 1 |
| 16 | Cloning and characterization of the1-deoxy-Z)-xylulose 5-phosphate reductoisomerase gene for diter-penoid tanshinone biosynthesis in Salvia miltiorrhiza ( Chinesesage) hairy roots显示文摘 | Shu J W Ming S Jian Y W | 2009 | Biotechnol Appl Biochem2009，52，1： | 1 |
| 17 | Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid显示文摘 | Han Y Y Ming F Wang W Wang J W Ye M M Sheng D L | 2006 | Genetica2006，128，123： | 1 |
| 18 | Agrobacterium-Mediated Genetic Transformation of a Dendrobium orchid 显示文摘 | Men S Z Ming X T Liu R W | 2003 | Plant Cell Tissue and Organ Culture2003，75，1： | 1 |
| 19 | Synthesis of nanosize poly(methyl methacrylate) microlatexes with high polymer content by a modified microemulsion potymerization显示文摘 | Ming W Jones F N Fu S | 1998 | Polym Bull1998，40，74： | 1 |
| 20 | Local structures around Mn luminescent centers in Mn-doped nanocrystals of ZnS显示文摘 | SOO Y L MING Z H HUANG S W | 1994 | Phys Bev B1994，50，： | 1 |
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