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| 1 | Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India显示文摘AIM:To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis(ITB)from Crohn’s disease(CD).METHODS:ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012.Routine investigations included case history,physical examination,blood biochemistry,ileocolonoscopy and histopathological examination of biopsies.Patients were followed-up after 2 and 6 mo of treatment.The diagnosis of ITB or CD was re-evaluated after 2 mo of antituberculous chemotherapy or immune suppressive therapy respectively,based on improvement in signs,symptoms and laboratory variables.This study was considered to be an exploratory analysis.Clinical,endoscopic and histopathological features recorded at the time of inclusion were subject to univariate analyses.Disease variables with sufficient number of recordings and P<0.05 were entered into logistic regression models,adjusted for known confounders.Finally,we calculated the odds ratios with respective confidence intervals for variables associated with either ITB or CD.RESULTS:This study included 38 ITB and 37 CD patients.Overall,ITB patients had the lowest body mass index(19.6 vs 22.7,P=0.01)and more commonly reported weight loss(73%vs 38%,P<0.01),watery diarrhoea(64%vs 33%,P=0.01)and rural domicile(58%vs 35%,P<0.05).Endoscopy typically showed mucosal nodularity(17/31 vs 2/37,P<0.01)and histopathology more frequently showed granulomas(10/30vs 2/35,P<0.01).The CD patients more frequently reported malaise(87%vs 64%,P=0.03),nausea(84%vs 56%,P=0.01),pain in the right lower abdominal quadrant on examination(90%vs 54%,P<0.01)and urban domicile(65%vs 42%,P<0.05).In CD,endoscopy typically showed involvement of multiple intestinal segments(27/37 vs 9/31,P<0.01).Using logistic regression analysis we found weight loss and nodularity of the mucosa were independently associated with ITB,with adjusted odds ratios of 8.6(95%CI:2.1-35.6)and 18.9(95%CI:3.5-102.8)respectively.Right lower abdominal quadrant pain on examination and involvement of≥3 intestinal segments were independently associated with CD with adjusted odds ratios of 10.1(95%CI:2.0-51.3)and 5.9(95%CI:1.7-20.6),respectively.CONCLUSION:Weight loss and mucosal nodularity were associated with ITB.Abdominal pain and excessive intestinal involvement were associated with CD.ITB and CD were equally common. | Geir Larsson Thrivikrama Shenoy Ramalingom Ramasubramanian Leena Kondarappassery Balakumaran Milada Cvancarova Smstuen Gunnar Aksel Bjune Bjφrn Allan Moum | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 2 | Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study)显示文摘 | Inger Camilla Solberg Idar Lygren J?rgen Jahnsen Erling Aadland Ole H?ie Milada Cvancarova Tomm Bernklev Magne Henriksen Jostein Sauar Morten H. Vatn Bj?rn Moum And the IBSEN Study Group | 2009 | Scandinavian Journal of Gastroenterology2009，，4： | 3 |
| 3 | Does in-house availability of multidisciplinary teams increase survival in upper gastrointestinal-cancer?显示文摘AIM: To investigate the effect of the establishment of in-house multidisciplinary team (MDT) availability (iMDTa) on survival in upper gastrointestinal cancer (UGI) patients. METHODS: In 2001, a cancer centre with irradiation and chemotherapy facilities was established in the Norwegian county of West Agder with a change of iMDTa (WA/MDT-Change). 'iMDTa'-status was defined according to the availability of the necessary specialists within one institution on one campus, serving the population of one county. We compared survival rates during 2000-2008 for UGI patients living in counties with (MDT-Yes), without (MDT-No), with a mix (MDT-Mix) and WA/MDT-Change. Survival was calculated with Kaplan-Meier method. Cox model was used to uncover differences between counties with different MDT status when adjusted for age, sex and stage. RESULTS: We analyzed 395 patients from WA/MDT-Change and compared their survival to 12 135 UGIpatients from four other Norwegian regions. Median overall survival for UGI patients in WA/MDT-Change increased from 129 to 300 d from 2000-2008, P = 0.001. The regions with the highest level of iMDTa achieved the largest decrease in risk of death for UGI cancers (compared to the county with MDT-Mix: MDT-Yes 11%, P <0.05 and WA/MDT-Change 15%, P < 0.05). Analyzing the different tumour entities separately, patients living in the WA/MDT-Change county reached a statisti-cally significant reduction in the risk of death [hazard ratios (HR)] compared to patients in the county with MDT-Mix for oesophageal and gastric, but not for pan-creatic cancer. HR for the study period 2000-2004 are given first and then for the period 2005-2008: The HR for oesophageal cancers was reduced from [HR = 1.12; 95%CI: 0.75-1.68 to HR = 0.60, 95%CI: 0.38-0.95] and for gastric cancers from [HR = 0.87, 95%CI: 0.66-1.15 to HR = 0.63, 95%CI: 0.43-0.93], but not for pancreatic cancer [HR = 1.04-, 95%CI: 0.83-1.3 for 2000-2004 and HR = 1.01, 95%CI: 0.78-1.3 for 2005-2008]. UGI patients treated during the second study period in the county of WA/MDT-Change had a higher probability of receiving chemotherapy. In the first study period, only one out of 43 patients (2.4%, 95%CI: 0-6.9) received chemotherapy, compared to 18 of 42 patients diagnosed during 2005-2008 (42.9%, 95%CI: 28.0-57.8). CONCLUSION: Introduction of iMDTa led to a two-fold increase of UGI patients, whereas no increase in survival was found in the MDT-No or MDT-Mix counties. | Christian Kersten Milada Cvancarova Svein Mjland Odd Mjland | 2013 | World Journal of Gastrointestinal Oncology2013，5，3： | 3 |
| 4 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 5 | Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients显示文摘AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease(IBD).METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep disturbance.RESULTS In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(CD) and 178(44%) had ulcerative colitis(UC). Vitamin D deficiency(< 50 nmol/L) was present in half(203/405) of the patients. Chronic fatigue was reported by 116(29%) of all included patients with substantial fatigue reported by 194(48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD patients.CONCLUSION In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed. | Svein Oskar Frigstad Marte Lie Hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset Gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen | 2018 | World Journal of Gastroenterology2018，24，29： | 2 |
| 6 | Effect of food preservatives on the inhibitory activity of acidocin CH5 and bacteriocin D 10显示文摘 | Marketa Giesova Jana Chumchalova Milada Plockova | 2004 | Eur Food Res Technol2004，218，： | 1 |
| 7 | Fluorescence Assay Based on Aptamer-Quantum Dot Binding to Bacillus thuringiensis Spores显示文摘 | Milada Ikanovic Walter E. Rudzinski John G. Bruno Amity Allman Maria P. Carrillo Sulatha Dwarakanath Suneetha Bhahdigadi Poornima Rao Johnathan L. Kiel Carrie J. Andrews | 2007 | Journal of Fluorescence2007，，2： | 1 |
| 8 | Bioaccumulation and toxicity of selenium compounds in the green alga Scenedesmus quadricauda显示文摘 | Dasa U Milada V Irena D | 2009 | BMC Plant Biology2009，9，： | 1 |
| 9 | Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors显示文摘 | Greg R.Angstreich WilliamMatsui Carol AnnHuff Milada S.Vala JamesBarber Anita L.Hawkins Constance A.Griffin B.Douglas Smith Richard J.Jones | 2005 | British Journal of Haematology2005，，： | 1 |
| 10 | A sensitive photometric assay for alcohol dehydrogetmse activity in blood serum显示文摘 | Skursky L Kovar J Milada S | 1979 | Analytical Biochemistry1979，99，1： | 1 |
| 11 | Aberrant O -glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma显示文摘 | Milada Stuchlová Horynová Milan Ra?ka Henrik Clausen Jan Novak | 2013 | Cellular and Molecular Life Sciences2013，，5： | 1 |
| 12 | New data on the cytology of parthenogenetic weevils (Coleoptera, Curculionidae)显示文摘 | Dorota Lachowska Maria Ro?ek Milada Holecová | 2008 | Genetica2008，，2： | 1 |
| 13 | Risk matrix model for prediction of colectomy in a population-based study of ulcerative colitis patients (the IBSEN study)显示文摘 | Inger Camilla Solberg Marte Lie H? ivik Milada Cvancarova Bj? rn Moum | 2015 | Scandinavian Journal of Gastroenterology2015，，12： | 1 |
| 14 | Risk Matrix for Prediction of Advanced Disease in a Population-based Study of Patients with Crohn?s Disease (the IBSEN Study)显示文摘 | Inger C. Solberg Milada Cvancarova Morten H. Vatn Bj?rn Moum | 2014 | Inflammatory Bowel Diseases2014，，1： | 1 |
| 15 | Net Emission Coefficients of Radiation in Air and SF6 ThermalPlasmas 显示文摘 | Vladimir Aubrecht Milada Bartlova | 2009 | Plasma Chem Plasma Process2009，29，： | 1 |
| 16 | Net Emission Coefficients of Radiation in Air and SFG Thermal Plas- mas显示文摘 | Vladimir Aubrecht Milada Bartlova | 2009 | Plasma Chem Plasma Process2009，，29： | 1 |
| 17 | Use of complementary and alternative medicine in patients with inflammatory bowel disease: results of a cross-sectional study in Norway显示文摘 | Randi Opheim Tomm Bernklev May Solveig Fagermoen Milada Cvancarova Bjorn Moum | 2012 | Scandinavian Journal of Gastroenterology2012，，12： | 1 |
| 18 | Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology显示文摘瞄准:评估腺瘤结肠息肉病(APC ) 蛋白质的损失的频率并且把 APC 地位与颜色的特征作比较表面的腺瘤。方法:APC 蛋白质的 Immunohistochemical 分析在 118 个腺瘤上被执行,结果与病人的恶意的潜力,腺瘤的地点,宏观的外观和年龄的参数相比。结果:APC 蛋白质的完全的损失在 28 被发现的 A (24%) 腺瘤,当(76%) 90 是 APC 时积极。腺瘤的吝啬的尺寸是 13.5 +/- 14.2 公里(95% CI 10.5-16.5 ) 在 APC 积极,并且 13.8 +/- 在 APC 否定的腺瘤的 15.5 公里(95% CI 7.8-19.8 )(P = 0.364 ) 。统计分析没至于组织学的类型揭示 APC 积极、否定的腺瘤之间的差别(P = 0.327 ) 并且发育异常的等级(P = 0.494 ) 。我们发现甚至先进的腺瘤没与非先进的肿瘤在他们的 APC 地位不同(P = 0.414 ) 。最后,当时,没有差别被发现地点(P = 0.157 ) ,宏观的外观(P = 0.571 ) 并且病人的年龄(P = 0.438 ) 在两个 APC 积极、否定的腺瘤之间被分析并且比较。结论:大多数腺瘤表示了全身的 APC 蛋白质,建议那蛋白质表情不是为对 APC 基因变化的评价的一个可靠标记。APC 蛋白质的完全的损失没影响腺瘤的形态学,地点,或外观,它也不受病人的年龄影响。 | Martin Bortlík Ivana Vítková Martina Pape(z|ˇ)ová Milada Kohoutová Ale(s|ˇ) Novotn(y|') Stanislav Adamec Petra Chalupná Milan Luká(s|ˇ) | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
| 19 | Impedance measurement of growth of lactic acid bacteria in the presence of nisin and lysozyme显示文摘 | Drahomíra Kozáková Jitka Holubová Milada Plocková | 2005 | Europe Food Resarch and Technology2005，221，6： | 1 |
| 20 | Determination of Sulphonamide Antibiotics and Trimethoprim in Wastewater and Sludge Using Liquid Chromatography with Diode-Array Detection显示文摘 | Petra Zenatova Milada Vavrova Ludmila Mravcova Hana Lisa | 2012 | Journal of Environmental Science and Engineering(A)2012，1，2： | 1 |
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