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| 1 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 2 | Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)显示文摘Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these caregivers.Methods:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD patients.The PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the caregivers.Caregiver ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent caregiving.Caregiver use of different coping strategies increased with worsening cognition.However,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also significant.Conclusions:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with MCI.Caregiver well-being has important implications for caregiver support,nursing home placement and disease course. | Ann J.Jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett Tim J.Anderson John C.Dalrymple-Alford | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 3 | 浅谈生产型低碳城市的路径与困境——以英国低碳建筑计划为例显示文摘1.前言
面对气候变化与能源问题,世界各国都在不断探索着降低碳排放的路径.长期依赖能源供应优待的城市必须从能源资源的消耗者逐渐过渡为自给自足的能源生产者.近年来,各种新能源技术的进步为实现生产型低碳城市提供了更多的机遇.前景最好的新的能源系统包括小规模的水电技术、风力发电技术、太阳能技术、现代生物物质技术和燃料电池技术等.然而较高的成本一直是新能源技术难于大范围推广的瓶颈.近年来,以政府补贴的方式推广新能源技术在城市中的使用是许多国家普遍采用的方式.如:在美国,百万太阳能屋顶计划帮助促进了太阳热系统和太阳能光伏系统在许多城市的推广;在日本,地球再生计划有力地推动了太阳能系统在城市地区的修建[1];在英国,低碳建筑计划资助了多种小规模可再生能源技术在城市中的使用.本文即以英国“低碳建筑计划”的经验为例,来探讨实现生产型低碳城市的可能路径以及现阶段尚待突破的困境,及对我国建设低碳城市的启示. | 孙璐 Phillip J.Jones | 2014 | 建筑与文化2014，，2： | 2 |
| 4 | Functional group characterization of indoor, outdoor, and personal PM2.5: results from RIOPA显示文摘 | A.Reff B. J.Turpin R. J.Porcja R.Giovennetti W.Cui C. P.Weisel J.Zhang J.Kwon S.Alimokhtari M.Morandi T.Stock S.Maberti S.Colome A.Winer D.Shendell J.Jones C.Farrar | 2004 | Indoor Air2004，，1： | 1 |
| 5 | Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors显示文摘 | Greg R.Angstreich WilliamMatsui Carol AnnHuff Milada S.Vala JamesBarber Anita L.Hawkins Constance A.Griffin B.Douglas Smith Richard J.Jones | 2005 | British Journal of Haematology2005，，： | 1 |
| 6 | 气割作业中割嘴的选择显示文摘 | J.Jones 李玉生 | 2005 | 铁道机车车辆工人2005，，1： | 1 |
| 7 | A tale of motor neurons and CD4+ T cells: moving forward by looking back显示文摘Amyotrophic lateral sclerosis(ALS) is a fatal progressive disorder characterized by the selective degeneration of motor neurons(MN). The impact of peripheral immune status on disease progression and MN survival is becoming increasingly recognized in the ALS research field. In this review, we briefly discuss findings from mouse models of peripheral nerve injury and immunodeficiency to understand how the immune system regulates MN survival. We extend these observations to similar studies in the widely used superoxide dismutase 1(SOD1) mouse model of ALS. Last, we present future hypotheses to identify potential causative factors that lead to immune dysregulation in ALS. The lessons from preceding work in this area offer new exciting directions to bridge the gap in our current understanding of immune-mediated neuroprotection in ALS. | Abhirami Kannan Iyer Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，4： | 1 |
| 8 | From government to governance: External influences on business risk management显示文摘 | Bridget M.Hutter Clive J.Jones | 2007 | Regulation & Governance2007，，1： | 1 |
| 9 | Designing Hardware for the Boundary Condition Round Robin Challenge显示文摘Qualification of products to their vibration and shock requirements in a laboratory setting consists of two basic steps.The first is the quantification of the product’s mechanical environment in the field.The second is the process of testing the product in the laboratory to ensure it is robust enough to survive the field environment.The latter part is the subject of the“Boundary Condition for Component Qualification”challenge problem.This paper describes the challenges in determining the appropriate boundary conditions and input stimulus required to qualify the product.This paper also describes the step sand analyses that were taken to design a set of hardware that demonstrates the issue and can be used by round robin challenge participants to investigate the problem. | David E.Soine Richard J.Jones Julie M.Harvie Troy J.Skousen Tyler F.Schoenherr | 2018 | Sound & Vibration2018，52，1： | 0 |
| 10 | Manipulating active layer morphology of molecular donor/polymer acceptor based organic solar cells through ternary blends显示文摘The development of molecular donor/polymer acceptor blend(MD/PA)-type organic solar cells(OSCs) lags far behind other type OSCs. It is due to the large-size phase separation morphology of MD/PAblend, which results from the high crystallinity of molecular donors. In this article, to suppress the crystallinity of molecular donors, we use ternary blends to develop OSCs based on one polymer acceptor(P-BNBP-f BT) and two molecular donors(DR3 TBDTT and BTR) with similar chemical structures.The ternary OSC exhibits a power conversion efficiency(PCE) of 4.85%, which is higher than those of the binary OSCs(PCE=3.60% or 3.86%). To our best knowledge, it is the first report of ternary MD/PA-type OSCs and this PCE is among the highest for MD/PA-type OSCs reported so far. Compared with the binary blends, the ternary blend exhibits decreased crystalline size and improved face-on orientation of the donors. As a result, the ternary blend exhibits improved and balanced charge mobilities, suppressed charge recombination and increased donor/acceptor interfacial areas, which leads to the higher shortcircuit current density. These results suggest that using ternary blend is an effective strategy to manipulate active layer morphology and enhance photovoltaic performance of MD/PA-type OSCs. | Zijian Zhang Zicheng Ding David J.Jones Wallace W.H.Wong Bin Kan Zhaozhao Bi Xiangjian Wan Wei Ma Yongsheng Chen Xiaojing Long ChuANDong Dou Jun Liu Lixiang Wang | 2018 | Science China Chemistry2018，61，8： | 0 |
| 11 | Reservoir quality of fluvial sandstone reservoirs in salt-walled mini- basins: an example from the Seagull field, Central Graben, North Sea, UK显示文摘The Triassic fluvial sandstones of the Skagerrak Formation were deposited in a series of salt-walled mini-basins and act as important hydrocarbon reservoirs for several high-pressure, high-temperature(HPHT) fields in the Central Graben, North Sea. The HPHT reservoirs exhibit excellent reservoir quality considering their depth of burial and hence have been of high interest for hydrocarbon exploration. This research uses a multidisciplinary approach to assess the Skagerrak Formation fluvial reservoir quality from the Seagull field incorporating core analysis, petrography, electron microscopy, XRD analysis, fluid inclusion appraisal and burial history modelling. Halokinesis and salt withdrawal at the margin of the saltwalled mini-basin induced early disaggregation bands and fractures at shallow burial and led to increased influx of meteoric water and clay mineral infiltration from overlying sedimentation. The density of disaggregation bands correlates with the occurrence and magnitude of pore-filling authigenic clay minerals, concentrated along the margin of the saltwalled mini-basin. The fluvial channel sandstones of the Skagerrak Formation are subject to strong intra-basinal spatial reservoir quality variations despite diagenesis and low vertical effective stress having played a favourable role in arresting porosity loss. | Stephan Stricker Stuart J.Jones Neil Meadows Leon Bowen | 2018 | Petroleum Science2018，15，1： | 0 |
| 12 | Recent advances in seasonal and multi-annual tropical cyclone forecasting显示文摘Seasonal tropical cyclone(TC)forecasting has evolved substantially since its commencement in the early 1980s.However,present operational seasonal TC forecasting services still do not meet the requirements of society and stakeholders:current operational products are mainly basin-scale information,while more detailed sub-basin scale information such as potential risks of TC landfall is anticipated for decision making.To fill this gap and make the TC science and services move forward,this paper reviews recent research and development in seasonal tropical cyclone(TC)forecasting.In particular,this paper features new research topics on seasonal TC predictability in neutral conditions of El Ni˜no–Southern Oscillation(ENSO),emerging forecasting techniques of seasonal TC activity including Machine Learning/Artificial Intelligence,and multi-annual TC predictions.We also review the skill of forecast systems at predicting landfalling statistics for certain regions of the North Atlantic,Western North Pacific and South Indian oceans and discuss the gap that remains between current products and potential user's expectations.New knowledge and advanced forecasting techniques are expected to further enhance the capability of seasonal TC forecasting and lead to more actionable and fit-for-purpose products. | Yuhei Takaya Louis-Philippe Caron Eric Blake Francois Bonnardot Nicolas Bruneau Joanne Camp Johnny Chan Paul Gregory Jhordanne J.Jones Namyoung Kang Philip J.Klotzbach Yuriy Kuleshov Marie-Dominique Leroux Julia F.Lockwood Hiroyuki Murakami Akio Nishimura Dushmanta R.Pattanaik Tom J.Philp Yohan Ruprich-Robert Ralf Toumi Frederic Vitart Seonghee Won Ruifen Zhan | 2023 | Tropical Cyclone Research and Review2023，12，3： | 0 |
| 13 | Correlation between the surface characteristics of carbon supports and their electrochemical stability and performance in fuel cell cathodes显示文摘In this paper,an extensive characterisation of a range of carbon blacks(CB)with similar surface area but different surface chemistry is carried out by flow calorimetry,Raman spectroscopy,dynamic water vapour sorption,instrumental gas analysis,nitrogen adsorption/desorption and high potential chronoamperometry.Using these carbon materials as supports,Pt/CB electrocatalysts are prepared by microwave-assisted polyol-mediated synthesis in gram scale.Structural,morphological and electrochemical properties of the prepared electrocatalysts are evaluated by X-ray diffraction,transmission electron microscopy,rotating disc electrode and in situ fuel cell characterisation of the corresponding membrane-electrode assemblies.The obtained results allow to establish a relationship between surface chemistry and electrochemical properties useful for the design of Pt/C catalyst layers with high performance and stability. | Ignacio Jiménez-Morales Alvaro Reyes-Carmona Marc Dupont Sara Cavaliere Marlene Rodlert Flavio Mornaghini Mikkel J.Larsen Madeleine Odgaard Jerzy Zajac Deborah J.Jones Jacques Rozière | 2021 | Carbon Energy2021，3，4： | 0 |
| 14 | Using Twitter Bios to Measure Changes in Self-Identity:Are Americans Defining Themselves More Politically Over Time?显示文摘Are Americans weaving their political views more tightly into the fabric of their self-identity over time?If so,then we might expect partisan disagreements to continue becoming more emotional,tribal,and intractable.Much recent scholarship has speculated that this politicization of Americans’identity is occurring,but there has been little compelling attempt to quantify the phenomenon,largely because the concept of identity is notoriously difficult to measure.We introduce here a methodology,Longitudinal Online Profile Sampling(LOPS),which affords quantifiable insights into the way individuals amend their identity over time.Using this method,we analyze millions of“bios”on the microblogging site Twitter over a 4-year span,and conclude that the average American user is increasingly integrating politics into their social identity.Americans on the site are adding political words to their bios at a higher rate than any other category of words we measured,and are now more likely to describe themselves by their political affiliation than their religious affiliation.The data suggest that this is due to both cohort and individual-level effects. | Nick Rogers Jason J.Jones | 2021 | Journal of Social Computing2021，2，1： | 0 |
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