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| 1 | 岩溶地下水脆弱性评价“二元法”及其在重庆金佛山的应用显示文摘岩溶地下水脆弱性评价是基于保护岩溶含水层从而有效地管理和利用地下水提出的有效方法和手段。我国西南岩溶区极大多数地区缺少应有的地下水保护带,地下水比较容易受到污染。本文论述了一种脆弱性的评价的简单方法——基于径流特征和覆盖层厚度的二元法,并利用该法对重庆金佛山典型岩溶区进行了地下水脆弱性评价。结果表明,药池坝洼地和生态石林区脆弱性较高。究其原因,尽管药池坝洼地底部土壤层覆盖较厚,但存在地表径流集中排向落水洞,生态石林分布区地表裂隙、溶沟发育,可直接接受雨水入渗,因而污染物极易通过降雨和地表径流过程进入含水层。这一方法输入数据量小,对岩溶含水层普遍适用,为地下水资源可持续利用和土地利用管理提供了强有力的工具。 | 章程 蒋勇军 Michèle Lettingue 王松 | 2007 | 中国岩溶2007，26，4： | 47 |
| 2 | 真空、脉冲真空和常压下蓝莓渗透脱水的研究显示文摘研究了真空渗透脱水、脉冲真空渗透脱水和常压渗透脱水下蓝莓水分含量和水分活度的变化规律,结果表明:真空渗透脱水时,蓝莓的水分含量和水分活度降低得最快。真空渗透脱水、脉冲真空渗透脱水、常压下渗透脱水蓝莓的有效水分扩散率分别为1.6777×10-9、1.3629×10-9、0.5679×10-9m2/s。真空渗透脱水、脉冲真空渗透脱水、常压下渗透脱水的有效固性物扩散率分别为9.1705×10-10、6.3919×10-10、5.1007×10-10m2/s。 | 董全 Michèle Marcotte 陈宗道 | 2007 | 食品科学2007，28，9： | 15 |
| 3 | Is there a role for surgery in stage ⅢA-N2 non-small cell lung cancer?显示文摘The role of surgery in stage ⅢA-N2 non-small cell lung cancer(NSCLC) remains controversial.Most important prognostic factors are mediastinal downstaging and complete surgical resection.Different restaging techniques exist to evaluate response after induction therapy and these are subdivided into non-invasive,invasive and alternative or minimally invasive techniques.In contrast to imaging or functional studies,remediastinoscopy provides pathological evidence of response after induction therapy.Although techn... | Paul E.VAN SCHIL Michèle DE WAELE Jeroen M.HENDRIKS Patrick R.LAUWERS | 2008 | 中国肺癌杂志2008，11，5： | 14 |
| 4 | Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus显示文摘Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus. | Maud Lemoine Aurélie Revaux Claire Francoz Guillaume Ducarme Sabine Brechignac Emmanuel Jacquemin Michèle Uzan Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，42： | 14 |
| 5 | Multi-resistant bacteria in spontaneous bacterial peritonitis: A new step in management?显示文摘Spontaneous bacterial peritonitis(SBP) is the most typical infection observed in cirrhosis patients. SBP is responsible for an in-hospital mortality rate of approximately 32%. Recently, pattern changes in the bacterial flora of cirrhosis patients have been observed, and an increase in the prevalence of infections caused by multi-resistant bacteria has been noted. The wide-scale use of quinolones in the prophylaxis of SBP has promoted flora modifications and resulted in the development of bacterial resistance. The efficacy of traditionally recommended therapy has been low in nosocomial infections(up to 40%), and multi-resistance has been observed in up to 22% of isolated germs in nosocomial SBP. For this reason, the use of a broad empirical spectrum antibiotic has been suggested in these situations. The distinction between community-acquired infectious episodes, healthcare-associated infections, or nosocomial infections, and the identification of risk factors for multi-resistant germs can aid in the decision-making process regarding the empirical choice of antibiotic therapy. Broad-spectrum antimicrobial agents, such as carbapenems with or without glycopeptides or piperacillin-tazobactam, should be considered for the initial treatment not only of nosocomial infections but also of healthcare-associated infections when the risk factors or severity signs for multi-resistant bacteria are apparent. The use of cephalosporins should be restricted to community-acquired infections. | Angelo Alves de Mattos Ane Micheli Costabeber Livia Caprara Lion?o Cristiane Valle Tovo | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 6 | 化妆品与皮肤健康——皮肤微生态显示文摘随着化妆品科学的飞速发展,化妆品在维持、改善和促进皮肤健康以及提高人们生活质量方面的作用越来越受到人们的重视。例如,保湿剂不仅能够通过增强皮肤屏障功能发挥其维持和增进皮肤健康的作用,还能有效改善和缓解由皮肤屏障受损所导致的皮肤问题[1]。目前,含有神经酰胺1、3、6(与人体角质层必需成分相似的保湿因子)的产品系列在修复受损的皮肤屏障方面的功效不仅被国内外皮肤科专家认同,也备受消费者喜爱[2]。同样,防晒剂不仅可以预防由日光中紫外线(UV)导致的皮肤光老化、皮肤色素沉着、光免疫抑制以及降低UV 导致的皮肤癌的风险,还可以预防某些皮肤病的发生,如多形性日光疹等[3]。另外,针对头皮屑的洗护发产品也为受头皮屑困扰的消费者提供了日常头皮护理的有效方法。 | 甄雅贤 张晨慧 Chopra Tarun Verschoore Michèle 刘玮 | 2019 | 临床皮肤科杂志2019，48，10： | 10 |
| 7 | Roasting and chlorine leaching of gold-bearing refractory concentrate:Experimental and process analysis显示文摘This paper deals with gold extraction from a refractory concentrate by chlorine leaching.The process considers a pre-treatment of refractory materials by low temperature oxidation carried out with low oxygen concentration.The oxidized material is treated by leaching with brine.After gold adsorption/reduction onto activated carbon,iron and base metals can be precipitated by NaOH.Roasting tests show the necessity to carry out a thermal pre-treatment at least at 550°C to obtain a reduction of sulfur and mercury in the material(50%and 90%,respectively).Highest gold extraction yield(around 93%)is obtained in the leaching test performed with material sample treated at 650°C.This result confrms the necessity to optimize the thermal pre-treatment to improve Au recovery and to reduce chlorine consumption.A comparison with conventional cyanidation confrms that chlorination could be an useful alternative:in fact,gold extraction yield is quite low:57%in non-pre-treated material and 25%in pre-treatment material. | Ida De Michelis Agostino Olivieri Stefano Ubaldini Francesco Ferella Francesca Beolchini Francesco Vegliò | 2013 | International Journal of Mining Science and Technology2013，23，5： | 10 |
| 8 | 兆伏级锥形束CT:系统说明及IGRT临床应用介绍显示文摘阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。 | Olivier Morin Amy Gillis Josephine Chen Michèle Aubin M.Kara Bucci Jean Pouliot 索京涛 陆嘉德 | 2006 | 中国癌症杂志2006，16，6： | 9 |
| 9 | 蓝莓渗透脱水的研究显示文摘在不同的渗透温度 ( 4 5~ 65℃ )条件下 ,高果糖浆和蔗糖的有效水分扩散率 (Dm)分别为( 4 90 60~ 5 2 3 66)× 1 0 - 10 m2 /s和 ( 3 5 5 1 8~ 4 0 1 0 9)× 1 0 - 10 m2 /s,有效固形扩散率 (Ds)分别为( 2 7740~ 3 691 5 )× 1 0 - 10 m2 /s和 ( 1 3 1 63~ 2 691 5 )× 1 0 - 10 m2 /s的规律。在渗透脱水处理过程中Dm 和Ds 随处理温度升高而增加。经高果糖浆 ( 70°Brix)渗透脱水的蓝莓的平均体积比随温度升高而稍微下降。 | 董全 Michèle Marcotte 陈宗道 | 2004 | 食品与发酵工业2004，30，7： | 7 |
| 10 | 急性脑梗死静脉溶栓治疗中凝血相关指标变化显示文摘目的:探讨纤维蛋白原、纤维蛋白降解产物、D-二聚体等凝血相关指标在急性缺血性脑卒中(AIS)静脉溶栓前后的改变。方法:选择80例发病后7h静脉内溶栓的急性大脑中动脉供血区AIS病例,观察溶栓前、溶栓后2h、溶栓后24h的凝血相关指标变化。结果:在AIS溶栓治疗中,纤维蛋白原在溶栓后2h较溶栓前降低(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.05);纤维蛋白溶解产物在溶栓后2h较溶栓前升高(P<0.01),溶栓24h后下降(P<0.01);D-二聚体在溶栓后2h较溶栓前升高(P<0.01),溶栓24h后降低(P<0.01),但仍高于溶栓前(P<0.01);ⅩⅢ因子水平在溶栓24h后明显下降(P<0.01);α2-抗纤溶酶水平在溶栓后2h较溶栓前下降(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.01);纤溶酶原水平在溶栓后2h较溶栓前下降(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.01);血小板在溶栓治疗后低于溶栓前,尤其是溶栓24h后(P<0.05)。结论:在AIS溶栓治疗中,纤维蛋白原、ⅩⅢ因子、α2-抗纤溶酶、纤维蛋白溶解酶原、D-二聚体、纤维蛋白降解产物及血小板都发生明显变化,与纤溶作用机制相符。 | 孙旭红 Paul Trouillas Miche Berthiller Michel Hanss 李威 翟宇 | 2011 | 中国临床神经科学2011，19，5： | 6 |
| 11 | TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?显示文摘 | Michèle Martin Jean-Louis Lefaix Sylvie Delanian | 2000 | International Journal of Radiation Oncology, Biology, Physics2000，，2： | 5 |
| 12 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 13 | Evolution of germination strategy in the invasive species Ulex europaeus显示文摘Aims The study of the adaptive potential of the germination patterns of invading species enables us to identify some traits linked with their capacity to colonize new sites,and to gain a better understanding of their area of distribution.The aim of this study is to determine the germination pattern of Ulex europaeus,a cosmopolitan invasive species,in relation to temperature and to explore its potential evolu-tion and invasiveness in a tropical region,following its introduction from Europe.Methods We studied the germination pattern of U.europaeus(the com-mon gorse)to test both physical dormancy and germination capacity within the range of temperatures found in the native and invasive regions.To understand its germination pattern and its evolution,the rate and the speed of germination,as well as the percentage of seeds that became mouldy during the experi-ment,have been compared between a native habitat,France and a habitat into which it has been introduced,the tropical island of La Reunion.Important Findings The results show that gorse seeds germinate in large quantities,pos-sess the ability to germinate under a wide range of temperatures and they confirm the physical dormancy of the seeds(caused by seed coat impermeability).The decrease in germination from 25℃ upwards,coupled with an increase in the rate of moulding help to explain its restricted distribution at altitude in tropical environments.For scari-fied seeds,we have not detected any difference between the two regions,neither in the percentage of germinated seeds,nor in the per-centage of mouldy seeds.However,seeds from Reunion germinate faster at 20℃ than seeds from France and a greater number of seeds from Reunion are able to germinate without scarification(10-60%for Reunion versus 0-10%for France).These results suggest that while preserving the advantages of the native habitat,in Reunion gorse develops a strategy which favours the rapid occupation of new sites. | Nathalie Udo Michèle Tarayre Anne Atlan | 2017 | Journal of Plant Ecology2017，10，2： | 4 |
| 14 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 15 | Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications显示文摘Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound healing.In this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO system.With the intention of adding subsidiary biological function,MBGNs were doped with Zn2+ions.Zn-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel method.The synthesized particles were homogeneous in shape and size.They exhibited spherical shape,good dispersity,and a size of 130±10 nm.The addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to MBGNs.The presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of immersion.Interestingly,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained manner.This releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of cells.Due to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing. | Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini | 2019 | Bioactive Materials2019，4，1： | 3 |
| 16 | African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era. | Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 17 | 渗透脱水蓝莓流化床干燥工艺的研究显示文摘经渗透脱水处理的蓝莓在流化床中用5种不同的干燥温度(50、60、70、80、90℃)进行干燥,结果显示, 干燥温度影响物料的水分散失,水分散失率随温度的提高而增加。随着干燥处理的进行水分含量和水分活度都呈下降趋势,且温度越高,两者下降越多。根据费克第二不稳定扩散法则,计算出不同温度下的有效水分扩散率 (D_(eff))分别为(0.753 2~3.673 7)×10^(-10)m^2/s。在干燥脱水处理过程中 D_(eff)随处理温度升高而增加。 | 董全 Michèle Marcotte 陈宗道 | 2006 | 食品与发酵工业2006，32，2： | 3 |
| 18 | Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data显示文摘 | Arduino Verdecchia Silvia Francisci Hermann Brenner Gemma Gatta Andrea Micheli Lucia Mangone Ian Kunkler | 2007 | Lancet Oncology2007，，9： | 3 |
| 19 | Comparison of mineral-based amendments for ex-situ stabilization of trace elements (As, Cd, Cu, Mo, Ni, Zn) in marine dredged sediments: A pilot-scale experiment显示文摘 | Yannick Mamindy-Pajany Charlotte Hurel Florence Geret Michèle Roméo Nicolas Marmier | 2013 | Journal of Hazardous Materials2013，，： | 2 |
| 20 | Management of infantile subglottic hemangioma: Acebutolol or propranolol?显示文摘 | Catherine Blanchet Richard Nicollas Michèle Bigorre Pascal Amedro Michel Mondain | 2010 | International Journal of Pediatric Otorhinolaryngology2010，，8： | 2 |
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