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| 1 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 2 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 3 | The value of sonohysterography in detecting intracavitary benign abnor-malities显示文摘 | Valenzano MM Lijoi D Mistrangelo E | 2005 | Arch Gynecol Obstet2005，272，4： | 1 |
| 4 | Shape analysis of female facial attractiveness 显示文摘 | Valenzano DR Mennucci A Tartarelli G | 2006 | Vision Res2006，46，89： | 1 |
| 5 | Screening and identi- fication of DNA aptamers to tyramine using in vitro selection and high-throughput sequencing显示文摘 | Valenzano S De Girolamo A DeRosa M C | 2016 | ACS Comb Sci2016，8，： | 1 |
| 6 | Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers显示文摘 | Xuexuan Wang Mary Carmen Valenzano Joanna M. Mercado E. Peter Zurbach James M. Mullin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 7 | The value of sonohysterography in detecting intracavitary benign abnormalities显示文摘 | Valenzano MM Lijoi D Mistrangelo E | 2005 | Arch Gynecol Obstet2005，272，4： | 1 |
| 8 | Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients显示文摘 | Casabona F Bogliolo S Valenzano Menada M | 2009 | Ann Surg Oncol2009，16，9： | 1 |
| 9 | Fluorescence Polarization Immunoassay for Rapid, Accurate and Sensitive Determination of Ochratoxin A in Wheat显示文摘 | Vincenzo Lippolis Michelangelo Pascale Stefania Valenzano Anna Chiara Raffaella Porricelli Michele Suman Angelo Visconti | 2014 | Food Analytical Methods2014，，2： | 1 |
| 10 | Delay analysis of priority promotion systems显示文摘 | Cena G Valenzano A | 2000 | Computer Communication2000，23，： | 1 |
| 11 | Pemetrexed disodi- um in ovarian cancer treatment 显示文摘 | Morotti M Valenzano Menada M | 2012 | Expert ()pin lnvestig Drugs2012，，： | 1 |
| 12 | Advances in auto- motive digital comrnunications显示文摘 | Cena G Valenzano A Vitturi S | 2005 | Computer Stand- ard and Interface2005，27，5： | 1 |
| 13 | Advances in automotive digital communications显示文摘 | Cena G Valenzano A Vitturi S | 2005 | Computer Standard and Interface2005，27，5： | 1 |
| 14 | Peripartum cardiomyopathy显示文摘 | Moioli M Valenzano Menada M Bentivoglio G | | 0，，02： | 1 |
| 15 | Transvaginal sonohysterographic evaluation of uterine malformations 显示文摘 | Valenzano MM Mistrangelo E Lijoi D | 2006 | Eur J Obstet Gyneeol Reprod Biol2006，124，2： | 1 |
| 16 | Vaginalultra2sonographic and hysterosonographic evaluation of the low transverse incision after cesarean section:correlation with gynaecological symptoms显示文摘 | Menada Valenzano M Lijoi D Mistrangelo E | 2006 | Gynecol Obstet Invest2006，61，4： | 1 |
| 17 | Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients显示文摘 | Casabona F Bogliolo S Valenzano Menada M | 2009 | Ann Surg oncol2009，16，9： | 1 |
| 18 | Pharmacological and phar-macokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy 显示文摘 | Valenzano K J Tafesse L Lee G | 2005 | Neuropharmacnlogy2005，48，5： | 1 |
| 19 | Peripartum car- diomyopathy 显示文摘 | Moioli M Valenzano Menada M Bentivoglio G | 2009 | Arch Gynecol Obstet2009，281，： | 1 |
| 20 | Performance Analysis of Ethernet Powerlink Networks for Distributed Control and Automation Systems显示文摘 | Cena G Seno L Valenzano A | 2009 | Computer Standards & Interfaces2009，31，3： | 1 |
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