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| 1 | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?显示文摘AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the 'no/minimal liver fibrosis' group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the 'advanced liver fibrosis' group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the 'no/minimal fibrosis' group included 79 individuals, while the 'advanced fibrosis' group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci | 2015 | World Journal of Gastroenterology2015，21，18： | 15 |
| 2 | Epinephrine plus argon plasma or heater probe coagulation in ulcer bleeding显示文摘AIM:To compare the effectiveness of argon plasma coagulation (APC) and heater probe coagulation (HPC) in non-variceal upper gastrointestinal bleeding.METHODS:Eighty-five (18 female,67 male) patients admitted for acute gastrointestinal bleeding due to gastric or duodenal ulcer were included in the study.Upper endoscopy was performed and HPC or APC were chosen randomly to stop the bleeding.Initial hemostasis and rebleeding rates were primary and secondary end-points of the study.RESULTS:Initial hemostasis was achieved in 97.7% (42/43) and 81% (36/42) of the APC and HPC groups,respectively (P < 0.05).Rebleeding rates were 2.4% (1/42) and 8.3% (3/36) in the APC and HPC groups,respectively,at 4 wk (P > 0.05).CONCLUSION:APC is an effective hemostatic method in bleeding peptic ulcers.Larger multicenter trials are necessary to confirm these results. | Ahmet Karaman Mevlut Baskol Sebnem Gursoy Edip Torun Alper Yurci Banu Demet Ozel Kadri Guven Omer Ozbakir Mehmet Yucesoy | 2011 | World Journal of Gastroenterology2011，17，36： | 4 |
| 3 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 4 | Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis显示文摘 | Murat Kekilli Bilge Tunc Yavuz Beyazit Mevlut Kurt Ibrahim Koral Onal Aysel Ulker Ibrahim Celalettin Haznedaroglu | 2013 | Digestive Diseases and Sciences2013，，5： | 1 |
| 5 | Mobile phone based SCADA for industrial automation显示文摘 | Engin Ozdemir Mevlut Karacor | 2006 | ISA Transactions2006，，1： | 1 |
| 6 | The use of waste ceramic tile in cement production 显示文摘 | NURAN A MEVLUT U | 2000 | Cement and Concrete Research2000，30，3： | 1 |
| 7 | Investigation of knitting architecture on the impact behavior of glass/epoxy composites显示文摘 | Alaattin A Mevlut T Mehmet A | 2013 | Composites: Part B2013，46，： | 1 |
| 8 | Production of Ricinoleic Acid from Castor Oil by Immobilised Lipases显示文摘 | Hakki Mevlut Ozcan Ayten Sagiroglu | 2009 | Preparative Biochemistry and Biotechnology2009，，2： | 1 |
| 9 | Effects of fibres denier, fibre cross-sectional shape and fabric density on acoustical behavior of vertically lapped nonwoven fabrics 显示文摘 | MEVLUT T EDWARD A V | 2008 | Journal of Engineered Fibres and Fabrics2008，，3： | 1 |
| 10 | The use of waste ceramic tile in cement production显示文摘 | Nuran Ay Mevlut Unal | 2000 | Cem Concr Res2000，30，3： | 1 |
| 11 | Comparison of four different time series methods to forecast hepatitis a virus infection显示文摘 | Mevlut Ture Imran Kurt | 2006 | Expert Systems with Applications2006，31，1： | 1 |
| 12 | Mobile Phone based SCADA for in- dustrial automation显示文摘 | ENGIN O MEVLUT K | 2006 | ISA Transactions2006，45，1： | 1 |
| 13 | Designing multi-field linear time-of-flight mass spectrometers with higher-order space focusing显示文摘 | MURAT Y OMER S MEVLUT D | | 0，，1： | 1 |
| 14 | Enucleation of Centrally Located Giant Hepatic Hemangioma: Report of Two Cases显示文摘 | Selcuk Mevlut Hazinedaroglu Huseyin Ayhan Kayaoglu Mehmet Ali Yerdel | 2006 | Digestive Diseases and Sciences2006，，7： | 1 |
| 15 | An experimental investigation of the bearing strength of weft-knitted 1 x 1 rib glass fiber composites 显示文摘 | Mevlut Tercan Osman Asi Alaattin Aktas | 2007 | Composite Structures2007，78，： | 1 |
| 16 | Experimental and numerical modeling of a sluice gate flow 显示文摘 | Akoz Mevlut Sami Kirkgoz Mehmet Salih Oner Ahmet Alper | 2009 | Journal of Hydraulic Research2009，47，2： | 1 |
| 17 | Effects of fiber denier, fiber cross-sectional shape and fabric density on acoustical behavior of vertically lapped nonwoven fabrics显示文摘 | Mevlut Tascan Edward A Vaughn | 2008 | Journal of Engineered Fibers and Fabrics2008，，3： | 1 |
| 18 | Efficacy of different therapeutic regimens on hepatic osteodystrophy in chronic viral liver disease显示文摘 | Alper Yurci Ali Osman Kalkan Omer Ozbakir Ahmet Karaman Edip Torun Mustafa Kula Mevlut Baskol Sebnem Gursoy Mehmet Yucesoy Fahri Bayram | 2011 | European Journal of Gastroenterology & Hepatology2011，，12： | 1 |
| 19 | Effects of fiber denier,fiber cross-sectional shape and fabric density on acoustical behavior of vertically lapped nonwoven fabrics显示文摘 | TASCAN Mevlut VAUGHN Edward A | 2008 | Journal of Engineered Fibers and Fabrics2008，，3： | 1 |
| 20 | Effect of obstacles on thermal stratification in hot water storage tanks 显示文摘 | Altuntop Necdet Arslan Mevlut Ozceyhan Veysel | 2005 | Applied Thermal Engineering2005，25，1415： | 1 |
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