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| 1 | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?显示文摘AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the 'no/minimal liver fibrosis' group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the 'advanced liver fibrosis' group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the 'no/minimal fibrosis' group included 79 individuals, while the 'advanced fibrosis' group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci | 2015 | World Journal of Gastroenterology2015，21，18： | 15 |
| 2 | Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis显示文摘 | Murat Kekilli Bilge Tunc Yavuz Beyazit Mevlut Kurt Ibrahim Koral Onal Aysel Ulker Ibrahim Celalettin Haznedaroglu | 2013 | Digestive Diseases and Sciences2013，，5： | 1 |
| 3 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 4 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 5 | Endoscopic and patholog-ical aspects of gastric polyps:A Turkish referral center study显示文摘 | Kekilli M Beyazit Y Karaman K | | 0，，116： | 1 |
| 6 | Novel noninvasive detection method for endometriosis: research and development of scintigraphic survey on endometrial implants in rats 显示文摘 | Hasealik S Celik O Kekilli E | 2008 | Fertil Steril2008，90，1： | 1 |
| 7 | Evaluation of cardiovascular risk factors and bone mineral density in post menopausal women undergoing coronary angiography显示文摘 | Tekin OG Kekilli E Yagmur J | 2008 | Int J Cardiol2008，131，1： | 1 |
| 8 | Evaluation of cardiovascular risk factors and bone mineral density in post menopausal women undergoing coronary angiography 显示文摘 | Tekin GO Kekilli E Yagmur J | 2008 | Int J Cardiot2008，131，1： | 1 |
| 9 | Can red cell distribution width help to discriminate benign from malignant biliaryobstruction? A retrospective single center analysis显示文摘 | Beyazit Y Kekilli M Ibis M | 2012 | Hepa- togastroenterology2012，59，117： | 1 |
| 10 | Ankaferd hemostat in the management of gastrointestinal hemorrhages显示文摘Gastrointestinal (GI) bleeding refers to any hemorrhage ascribed to the pathologies of the gastrointestinal tract,extending from the mouth to the anal canal.Despite the recent improvements in the endoscopic,hemostatic and adjuvant pharmacologic techniques,the reported mortality is still around 5%-10% for peptic ulcer bleeding and about 15%-20% for variceal hemorrhages.Although endoscopic management reduces the rates of re-bleeding,surgery,and mortality in active bleeding;early recurrence ratios still occur in around 20% of the cases even with effective initial hemostatic measures.In this quest for an alternative pro-hemostatic agent for the management of GI bleedings,Ankaferd blood stopper (ABS) offers a successful candidate,specifically for 'difficult-to-manage' situations as evidenced by data presented in several studies.ABS is a standardized mixture of the plants Thymus vulgaris,Glycyrrhiza glabra,Vitis vinifera,Alpinia officinarum,and Urtica dioica.It is effective in both bleeding individuals with normal hemostatic parameters and in patients with deficient primary and/or secondary hemostasis.ABS also modulates the cellular apoptotic responses to hemorrhagic stress,as well as hemostatic hemodynamic activity.Through its effects on the endothelium,blood cells,angiogenesis,cellular proliferation,vascular dynamics,and wound healing,ABS is now becoming an effective alternative hemostatic medicine for gastrointestinal bleedings that are resistant to conventional anti-hemorrhagic measurements.The aim of this review is to outline current literature experience suggesting the place of ABS in the management of GI bleeding,and potential future controlled trials in this complicated field. | Yavuz Beyazit Murat Kekilli Ibrahim C Haznedaroglu Ertugrul Kayacetin Metin Basaranoglu | 2011 | World Journal of Gastroenterology2011，17，35： | 1 |
| 11 | ERCP experience in pa- tients with choledochoduodenostomy: diagnostic findings and therapeutic management显示文摘 | Demirel B Kekilli M Onal I | 2011 | Surg Endosc2011，25，4： | 1 |
| 12 | Can red cell distribution width help to discriminate benign from malignant biliary obstruction? A retrospective single center analysis显示文摘 | Beyazit Y Kekilli M Ibis M | | 0，，117： | 1 |
| 13 | Atypical pANCA as a marker of indeterminate colitis for the prediction of ulcerative colitis and Crohn′s disease显示文摘 | Kekilli M Beyazit Y Tas A | | 0，，9： | 1 |
| 14 | Can red cell distribution width help to discriminate benign from malignant biliary obstruction? A retrospective single center analysis 显示文摘 | Beyazit Y Kekilli M Ibis M | 2012 | Hepatogas-troenterology2012，59，： | 1 |
| 15 | Evaluation of cardiovascular risk factors and bone mineral density in post menopausal women undergoing coronaryangiography显示文摘 | Tekin O G Kekilli E Yagmur J Uckan A Yagmur C Aksoy Y | 2008 | Int J Cardiol2008，131，： | 1 |
| 16 | ERCP experience in patients with choledochoduodenostomy: diagnostic findings and therapeutic management显示文摘 | Dcmirel BT Kekilli M Onal IK | 2011 | Surg Endos2011，25，4： | 1 |
| 17 | Ovarian carcinoma in two patients with chronic liver disease显示文摘Ascites is a common and debilitating complication of cirrhosis. However, patients with chronic liver disease are not spared from other causes of ascites and physicians should be careful not to miss an underlying malignancy.Ovarian cancer is an insidious disease, which is difficult to diagnose and it ranks first in mortality among all gynecological cancers. Here, we present two cases of patients with chronic liver disease that developed ascites not simply because of cirrhosis but as a manifestation of ovarian cancer. We would like to emphasize that the causes of ascites, other than the liver itself, should not be overlooked in patients with chronic liver disease. | Mehlika Lsildak Murat Kekilli Yavuz Beyazit Gulay Sain Guven Mustafa Erman Gulay Sain Guverl Mustafa Ermall | 2005 | World Journal of Gastroenterology2005，11，28： | 0 |
| 18 | Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours显示文摘Neuroendocrine tumors(NETs)are a rare and heterogeneous disease group and constitute 0.5%of all malignancies.The annual incidence of NETs is increasing worldwide.The reason for the increase in the incidence of NETs is the detection of benign lesions,incidental detection due to the highest use of endoscopic and imaging procedures,and higher recognition rates of pathologists.There have been exciting developments regarding NET biology in recent years.Among these,first of all,somatostatin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis,hormone secretion,and proliferation.Subsequently,activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism.Finally,the importance of proangiogenic factors(platelet-derived growth factor,vascular endothelial growth factor,fibroblastic growth factor,angiopoietin,and semaphorins)in the progression of NET has been determined.Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment. | Ahmet Yozgat Murat Kekilli Mustafa Altay | 2021 | World Journal of Clinical Cases2021，9，29： | 0 |
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