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| 1 | Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats显示文摘Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal. | KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 2 | GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer显示文摘Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each year.Growth/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in CRC.It induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and metastasis.Some studies indicate that GDF-15 may stimulate angiogenesis in malignant neoplasms.However,it has not been investigated in CRC yet.The aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM staging.The study comprised 33 samples of tumor and margin tissues obtained from CRC patients.To assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were used.We found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor tissue.The levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin tissue.In CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 expression.Our study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in CRC.The elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors. | Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska | 2021 | Current Medical Science2021，41，3： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Maturation, proliferation and apoptosis of seminal tubule cells at puberty after administration of estradiol, follicle stimulating hormone or both显示文摘瞄准:为了在雌二醇,滤泡刺激荷尔蒙(FSH ) 或两个代理人的影响下面在新生的老鼠在与 Sertoli 房间成熟的关系估计增生的和生精的上皮房间的 apoptotic 潜力,一起给。方法:从出生后的白天(PND ) , 5 ~ 15 只雄的老鼠每天与 17 β - estradiol (EB ) 的 12.5 μ g 被注射或人的 7.5 IU 净化了 FSH (hFSH )( 控制) 或 EB + hFSH 或溶剂。在出生后的白天 16,尸体被执行。Sertoli 房间成熟 / 功能被形态测定法估计。生精的上皮房间的增长是用免疫评估的份量上对增殖的房间的组织化学的标记用 TUNEL 方法的原子抗原和 apoptosis。结果:尽管 EB 禁止了 Sertoli 房间成熟, hFSH 不是有效的, Sertoli 房间成熟的显著加速发生在 EB + hFSH 以后。而 hFSH 刺激了 Sertoli 房间增长, EB 或 EB + hFSH 禁止了 Sertoli 房间增长。所有处理显著地刺激了细菌房间增长。Sertoli 房间的 Apoptosis 在 EB 以后增加了 9 褶层和生殖细胞 2 褶层,并且没被 hFSH 影响,但是在 EB + hFSH 以后被禁止。结论:在发身,雌二醇禁止 Sertoli 房间成熟,增加 Sertoli 和细菌房间 apoptosis,但是刺激细菌房间增长。在有 FSH 的协同的雌二醇,而是两荷尔蒙独自一个,加速与细菌房间幸存的增加联系的 Sertoli 房间成熟。雌二醇和 FSH 合作导致精液的小管成熟并且触发第一精子发生。 | Renata Walczak-Jedrzejowska Jolanta Slowikowska-Hilczer Katarzyna Marchlewska Krzysztof Kula | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 5 | Newly developed Fe3O4–Cr2O3 magnetic nanocomposite for photocatalytic decomposition of 4-chlorophenol in water显示文摘Chlorophenols, typically 4-chlorophenols are highly toxic and non-biodegradable organic contaminants which pose serious threat to the environment, particularly when released into aqueous medium. The removal of these pollutants by efficient method has received worldwide concern in recent past. A new Fe_3O_4–Cr_2O_3 magnetic nanocomposite was synthesized by wet chemical method under ultrasonic irradiation. Microstructure and morphology of the nanocomposite were characterized by powder X-ray diffraction(XRD),Fourier transform infrared(FT-IR), and a transmission electron microscope(TEM). Magnetic and optical properties were studied by a vibrating sample magnetometer(VSM) and an ultraviolet–visible(UV–Vis) spectrophotometer respectively. The magnetic nanocomposite(MNC) was used as photocatalyst for effective decomposition of 4-chlorophenol in water under ultraviolet(UV) irradiation. | Khoirakpam Kesho Singh Kula Kamal Senapati Chandan Borgohain Kanak Chandra Sarma | 2017 | Journal of Environmental Sciences2017，29，2： | 2 |
| 6 | Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment显示文摘 | OZSOY S ESEL E KULA M | 2009 | Psychiatry Res2009，169，3： | 1 |
| 7 | The case of land misallocation in northern ireland显示文摘 | Kula E | 1988 | Irish Journal of Agricultural Economics and Rural Sociology1988，13，： | 1 |
| 8 | Removal of ammonia nitrogen by the precipitation method,an the example of some selected wastewaters显示文摘 | Zdybiewska M W and Kula B | 1991 | Water Science and Technology1991，24，7： | 1 |
| 9 | Technical aspects of extractive enzyme purifieation显示文摘 | KULA M R HUSTEDT H SCHUTTE H | 1987 | Am NY Acad Sci1987，396，： | 1 |
| 10 | Employee motivation:addressing a crucial factor in your organization's performance 显示文摘 | KULA A | 1995 | Employment Relations Today1995，22，2： | 1 |
| 11 | The regional cerebral blood flow changes in major depressive disorder with and without psychotic features 显示文摘 | Gonul AS Kula M Bilgin AG | 2004 | Prog Neuropsychopharmacol Biol Psychiatry2004，28，6： | 1 |
| 12 | Extraction of cholesterol oxidase from Nocardia rhodochrous using a nonionie surfactant-based aqueous two-phase system 显示文摘 | MINUTH T THOMMES J KULA M R | 1995 | Biotechnol Appl Biochnol1995，23，： | 1 |
| 13 | Preoperative acetaminophen vs ibuprofen for control of pain after orthodontic separator placement显示文摘 | Bird SE Williams K Kula K | 2007 | Am J Orthod Dentofacial Orthop2007，132，4： | 1 |
| 14 | Membrane chromatography-An integrative concept in the downstream 显示文摘 | THOMMES J KULA M R | 1995 | Processing of Proteins Biotechnology Progress1995，11，： | 1 |
| 15 | General synthesis method of alkyl-alkoxy multifluorotolanes for negative high birefringence nematic mixtures显示文摘 | Dziaduszek J Kula P Da.browski R | | 0，，02： | 1 |
| 16 | Mechanisms of cerebellar tonsil herniation in patients with Chiari malformations as guide to clin- ical management 显示文摘 | Milhorat TH Nishikawa M Kula RW | 2010 | Acta Neurochir2010，152，5： | 1 |
| 17 | Comparison of ALOHA and EPI code for safety analysis applications显示文摘 | Thoman D C O'kula K R etc | 2006 | Journal of Chemical Health and Safety2006，13，6： | 1 |
| 18 | The transmembrane protein-tyrosine phosphatase CD45 is associated withdecreased insulin receptor signaling 显示文摘 | Kulas D T Freund G G Mooney R A | 1996 | J Biol Chem1996，271，： | 1 |
| 19 | Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4 - S5 显示文摘 | Bendahhou S Cummins TR Kula RW | 2002 | Neurology2002，58，8： | 1 |
| 20 | Improvement for L- Leueine production in a continuously operated enzyme membrane reactor显示文摘 | Ohshima T Wandrey C Kula M R | 1985 | Bioteehnology and Bioengineering1985，27，11： | 1 |
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