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| 1 | Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice显示文摘AIM: To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis (SBP) in clinical practice. METHODS: All SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear (PMN) cell count was > 250 cells/mm3, and empirically treated with cefotaxime. RESULTS: Thirty-eight SBP episodes occurred in 32 cirrhotics (22 men/10 women; mean age: 58.6 ± 11.2 years). Prevalence of SBP, in our population, was 17%. Ascitic fluid culture was positive in nine (24%) cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage (44%) similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime. CONCLUSION: In clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment andevaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with antibiotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated. | Stefania Angeloni Cinzia Leboffe Antonella Parente Mario Venditti Alessandra Giordano Manuela Merli Oliviero Riggio | 2008 | World Journal of Gastroenterology2008，14，17： | 42 |
| 2 | Ascitic fluid analysis for diagnosis and monitoring of spontaneous bacterial peritonitis显示文摘Polymorphonuclear (PMN) cell count in the ascitic fluid is essential for the diagnosis and management of spontaneous bacterial peritonitis (SBP). To date, PMN cell count is routinely performed by traditional manual counting. However, this method is time-consuming, costly, and not always timely available. Therefore, considerable efforts have been made in recent years to develop an alternative test for a more rapid diagnosis and monitoring of SBP. The use of urinary reagent strips was proposed to achieve an 'instant' bedside diagnosis of SBP. A series of reports evaluated the urine strip test for SBP diagnosis and reported promising results. However, a recent large multicenter study revealed a surprising lack of diagnostic effi cacy of the urine screening test for SBP diagnosis. Another method, more recently proposed as an alternative to the manual PMN count, is the measurement of lactoferrin in ascitic fluid, but the data available on the diagnostic value of this test are limited to a single study. However, both urinary reagent strips and ascitic lactoferrin tests are qualitative methods and need, therefore, to be further confirmed by standard cytology of the ascitic fluid. To date, the only quantitative method proposed as a valid alternative to manual PMN counting is automated blood cell counters, commonly used in all laboratories for blood cell counting. Data available in the literature on the diagnostic performance of this method are limited but very promising, and this tool seems to have the potential to replace the manual counting method. | Oliviero Riggio Stefania Angeloni | 2009 | World Journal of Gastroenterology2009，15，31： | 33 |
| 3 | Antiglycative activity of sulforaphane: a new avenue to counteract neurodegeneration?显示文摘Neurodegeneration is a key aspect of a large number of diseases that come under the umbrella of'neurodegenerative diseases'with the most notable being Parkinson’s,Alzheimer’s,and Huntington’s diseases(AD,PD,HD).They are all incurable and debilitating conditions that result in progressive degeneration and/or death of neurons and are the leading cause of | Cristina Angeloni Marco Malaguti Silvana Hrelia | 2015 | Neural Regeneration Research2015，10，11： | 7 |
| 4 | Accuracy of the automated cell counters for management of spontaneous bacterial peritonitis显示文摘AIM: To evaluate the accuracy of automated blood cell counters for ascitic polymorphonuclear (PMN) determination for: (1) diagnosis, (2) efficacy of the ongoing antibiotic therapy, and (3) resolution of spontaneous bacterial peritonitis (SBP). METHODS: One hundred and twelve ascitic fluid samples were collected from 52 consecutive cirrhotic patients, 16 of them with SBP. The agreement between the manual and the automated method for PMN count was assessed. The sensitivity/specificity and the positive/negative predictive value of the automated blood cell counter were also calculated by considering the manual method as the 'gold standard' . RESULTS: The mean ± SD of the difference between manual and automated measurements was 7.8 ± 58 cells/mm3, while the limits of agreement were +124 cells/mm3 [95% confidence interval (CI): +145 to +103] and -108 cells/mm3 (95% CI: -87 to -129). The automated cell counter had a sensitivity of 100% and a specificity of 97.7% in diagnosing SBP, and a sensitivity of 91% and a specificity of 100% for the efficacy of the ongoing antibiotic therapy. The two methods showed a complete agreement for the resolution of infection. CONCLUSION: Automated cell counters not only have a good diagnostic accuracy, but are also very effective in monitoring the antibiotic treatment in patients with SBP. Because of their quicker performance, they should replace the manual counting for PMN determination in the ascitic fluid of patients with SBP. | Oliviero Riggio Stefania Angeloni Antonella Parente Cinzia Leboffe Giorgio Pinto Teresa Aronne Manuela Merli | 2008 | World Journal of Gastroenterology2008，14，37： | 6 |
| 5 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 4 |
| 6 | Frequency content of whole body gait kinematic data 显示文摘 | Angeloni C Riley P Krebs D | 1994 | IEEE Transactions on Rehabilitation Engineering1994，2，1： | 1 |
| 7 | Platelet-leukocyte mixed conjugates in patients with atrial fibrillation显示文摘 | Alberti S Angeloni G Tamburrelli C | 2009 | Platelets2009，20，： | 1 |
| 8 | Glycoprofiling with micro-array of glycoconjugates and lectins显示文摘 | ANGELONI S RIDETN J L KUSY N | 2005 | Glycobiology2005，15，1： | 1 |
| 9 | Euro area inflation differentials显示文摘 | Angeloni I Ehrmann M | | 0，，01： | 1 |
| 10 | Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src显示文摘 | Danilkovitch-Miagkova A Angeloni D Skeel A | 2000 | J Biol Chem2000，275，14： | 1 |
| 11 | Overexpression and activation of the RON receptor tyrosine kinase in a panel of human coloreeta| carcinoma cell lines 显示文摘 | Chen YQ Zhou YQ Angeloni D | 2000 | Exp Cell res2000，261，： | 1 |
| 12 | CIinical efficacy of transjugular intrahepatic portosystemic shunt created with covered stents with different diameters: results of a randomized controlled trial显示文摘 | Riggio O Ridola L Angeloni S | 2010 | J Hepatol2010，53，2： | 1 |
| 13 | Monetary Policy and Risk Taking显示文摘 | Angeloni I Faia E Duca M L | 2015 | Jour- nal of Economic Dynamics and Control2015，，52： | 1 |
| 14 | Modulation of phase 11 enzymes by sulforaphane: implications for its cardioprotective poten- tial显示文摘 | Angeloni C Leoncini E Malaguti M | 2009 | J Agile Food Chem2009，57，： | 1 |
| 15 | Green tea extracts can counteract the modification of fatty acid composition induced by doxorubicin in cultured cardiomyocytes显示文摘 | Hrelia S Bordoni A Angeloni C | 2002 | Prostaglandins Leukotrienes and Essential Fatty Acids2002，66，5： | 1 |
| 16 | Acquired digital fihrokeratoma显示文摘 | Vinson RP Angeloni VL | 1995 | Am Faro Physician1995，52，5： | 1 |
| 17 | Randomized clinical trial examining the effect of music on therapy in stress response to day surgery显示文摘 | Leardi S Pietroletti R Angeloni G | 2007 | Br J Surg2007，94，8： | 1 |
| 18 | Glycoprofiling withmicro-arrays of glycoconjugates and lectins显示文摘 | Angeloni S Ridet JL Kusy N | 2005 | Glycobiology2005，15，1： | 1 |
| 19 | Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines显示文摘 | Chen YQ Zhou YQ Angeloni D | 2000 | Exp Cell Res2000，261，1： | 1 |
| 20 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Merli M Nicolini G Angeloni S | 2003 | J Hepatol2003，38，3： | 1 |
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