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| 1 | Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications显示文摘AIM: The significance of preoperative serum IL-6, TNFαand CRP levels in the progression of colorectal cancer (CRC) has not been fully elucidated. Our intention was to investigate their role and identify their prognostic significance.METHODS: The IL-6, TNFα and CRP levels were measured in 74 CRC patients and the relationships between their elevation s and both the clinicopathological factors and prognosis of patients were investigated. Serum concentrations of human IL-6 and TNFα were determined by enzyme-linked immunosorbent assay (ELISA). CRP was measured by an immunoturbinometric method.RESULTS: Median IL-6, TNFα and CRP levels weresignificantly higher in CRC patients than in normal controls.High levels of serum IL-6, TNFα and CRP were correlated with larger tumor size. Furthermore, high IL-6 and high CRP levels were associated with reduced overall survival.CONCLUSION: Serum IL-6, TNFα and CRP levels definitely increase in CRC patients. Pre-operative serum elevation of IL-6 and CRP was thus found to be predictor of the prognosis of CRC patients. The clinical value of TNFα in CRC needs to be further investigated. | Nikolaos I. Nikiteas Nikolaos Tzanakis Maria Gazouli George Rallis Kessaris Daniilidis George Theodoropoulos Alkiviadis Kostakis George Peros | 2005 | World Journal of Gastroenterology2005，11，11： | 23 |
| 2 | Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology显示文摘AIM:To assess human epidermal growth factor receptor-2 (HER2)-status in gastric cancer and matched lymph node metastases by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH).METHODS:120 cases of primary gastric carcinomas and 45 matched lymph node metastases from patients with full clinicopathological features were mounted onto multiple-punch and single-punch tissue microarrays,respectively,and examined for HER2 overexpression and gene amplification by IHC and CISH.RESULTS:Twenty-four tumors (20%) expressed HER2 immunohistochemically.An IHC score of ≥ 2+ was observed in 20 tumors (16.6%).HER2 amplification was detected by CISH in 19 tumors (15.8%) and in their matched lymph node metastases.A high concordancerate was found between HER2 positivity (as detected by IHC) and HER2 gene amplification (as detected by CISH),since 19 of the 20 IHC positive cases were amplified (95%).All amplified cases had 2+ or 3+ IHC results.Amplification was associated with intestinal phenotype (P < 0.05).No association with grading,staging or survival was found.CONCLUSION:In gastric cancer,HER2 amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases. | Dimitrios Tsapralis Ioannis Panayiotides George Peros Theodore Liakakos Eva Karamitopoulou | 2012 | World Journal of Gastroenterology2012，18，2： | 8 |
| 3 | TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer显示文摘BACKGROUND Patients with stage II-III colorectal cancer (CRC) treated with adjuvant chemotherapy, gain a 25% survival benefit. In the context of personalized medicine, there is a need to identify patients with CRC who may benefit from adjuvant chemotherapy. Molecular profiling could guide treatment decisions in these patients. Thymidylate synthase (TYMS) gene polymorphisms, KRAS and BRAF could be included in the molecular profile under consideration. AIM To investigate the association of TYMS gene polymorphisms, KRAS and BRAF mutations with survival of CRC patients treated with chemotherapy.METHODS A retrospective study studied formalin-fixed paraffin-embedded tissues (FFPEs) of consecutive patients treated with adjuvant chemotherapy during January/2005-January/2007. FFPEs were analysed with PCR for the detection of TYMS polymorphisms, mutated KRAS (mKRAS) and BRAF (mBRAF). Patients were classified into three groups (high, medium and low risk) according to 5’UTR TYMS polymorphisms Similarly, based on 3’UTR polymorphism ins/loss of heterozygosity (LOH) patients were allocated into two groups (high and low risk of relapse, respectively). Cox regression models examined the associated 5- year survival outcomes. RESULTS One hundred and thirty patients with early stage CRC (stage I-II: 55 patients;stage III 75 patients;colon: 70 patients;rectal: 60 patients) were treated with surgery and chemotherapy. The 5-year disease free survival and overall survival rate was 61.6% and 73.9% respectively. 5’UTR polymorphisms of intermediate TYMS polymorphisms (2RG/3RG, 2RG/LOH, 3RC/LOH) were associated with lower risk for relapse [hazard ratio (HR) 0.320, P = 0.02 and HR 0.343, P = 0.013 respectively] and death (HR 0.368, P = 0.031 and HR 0.394, P = 0.029 respectively). The 3’UTR polymorphism ins/LOH was independently associated with increased risk for disease recurrence (P = 0.001) and death (P = 0.005). mBRAF (3.8% of patients) was associated with increased risk of death (HR 4.500, P = 0.022) whereas mKRAS (39% of patients) not. CONCLUSION Prospective validating studies are required to confirm whether 2RG/3RG, 2RG/LOH, 3RC/LOH, absence of ins/LOH and wild type BRAF may indicate patients at lower risk of relapse following adjuvant chemotherapy. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas Georgia Vourli George Peros Iordanis Papadopoulos Ioannis Panayiotides Anna Koumarianou | 2019 | World Journal of Gastrointestinal Oncology2019，11，7： | 5 |
| 4 | Cytomegalovirus immune evasion by perturbation ot endosomal trafficking显示文摘 | Pero Lucin Hana Mahmutefendic Gordana Blagojevic Zagorac Maja Ilic Tomas | 2015 | Cellular & Molecular Immunology2015，12，2： | 5 |
| 5 | Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer显示文摘AIM To investigate the impact of thymidylate synthase(TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer(m CRC) patients treated with chemotherapy. METHODS Clinical data were collected retrospectively from records of consecutive patients with m CRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untranslated region(UTR) and 5'UTR were classified into three groups according to the probability they have for high, medium and low TYMS expression(and similar levels of risk) based on evidence from previous studies. Univariate and multivariate survival analyses were performed.RESULTS The analysis recovered 89 patients with m CRC(46.1% de novo metastatic disease and 53.9% relapsed). Of these, 46 patients(51.7%) had colon cancer and 43(48.3%) rectal cancer as primary. All patients were treated with fluoropyrimidine-based chemotherapy(5FU or capecitabine) as single-agent or in combination with irinotecan or/and oxaliplatin or/and bevacizumab. With a median follow-up time of 14.8 mo(range 0-119.8), 85 patients(95.5%) experienced disease progression, and 63 deaths(70.8%) were recorded. The 3-year and 5-year OS rate was 25.4% and 7.7% while the 3-year progression-free survival rate was 7.1%. Multivariate analysis of TYMS polymorphisms, KRAS and BRAF with clinicopathological parameters indicated that TYMS 3'UTR polymorphisms are associated with risk for disease progression and death(P < 0.05 and P < 0.03 respectively). When compared to tumors without any del allele(genotypes ins/ins and ins/loss of heterozygosity(LOH) linked with high TYMS expression) tumors with del/del genotype(low expression group) and tumors with ins/del or del/LOH(intermediate expression group) have lower risk for disease progression(HR = 0.432, 95%CI: 0.198-0.946, P < 0.04 and HR = 0.513, 95%CI: 0.287-0.919, P < 0.03 respectively) and death(HR = 0.366, 95%CI: 0.162-0.827, P < 0.02 and HR = 0.559, 95%CI: 0.309-1.113, P < 0.06 respectively). Additionally,KRAS mutation was associated independently with the risk of disease progression(HR = 1.600, 95%CI: 1.011-2.531, P < 0.05). The addition of irinotecan in 1st line chemotherapy was associated independently with lower risk for disease progression and death(HR = 0.600, 95%CI: 0.372-0.969, P < 0.04 and HR = 0.352, 95%CI: 0.164-0.757, P < 0.01 respectively).CONCLUSION The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in m CRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas George Peros Stefanos Konstantoudakis Danai Leventakou Ioannis G Panayiotides Petros Karakitsos Anna Koumarianou | 2017 | World Journal of Gastroenterology2017，23，32： | 4 |
| 6 | Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis显示文摘Metastatic disease from cutaneous melanoma can af-fect all organs of the body, and varies in its biological behavior and clinical presentation. We present the case of a 58-year-old man who arrived at our clinic with acute abdominal pain, which, after investigation, was diagnosed as acute cholecystitis. The patient under-went laparotomy and cholecystectomy. Two years ago, he underwent surgical removal of a primary cutaneous melanoma on his right upper back. Pathological exami-nation revealed the presence of malignant melanoma with a metastatic lesion of the gallbladder. | Spiridon Vernadakis Georgios Rallis Nikolaos Danias Costas Serafi midis Evangelos Christodoulou Michail Troullinakis Nikolaos Legakis Georgios Peros | 2009 | World Journal of Gastroenterology2009，15，27： | 3 |
| 7 | Isoenzyme(s)of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study显示文摘 | Seidegard J Pero RW Markowitz MM | 1990 | Carcinogenesis1990，11，： | 2 |
| 8 | Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis显示文摘 | Claus Schildberg R. Croner S. Merkel V. Schellerer V. Müller S. Yedibela W. Hohenberger G. Peros A. Perrakis | 2012 | World Journal of Surgery2012，，4： | 2 |
| 9 | Asymptomatic Cholelithiasis: Is Cholecystectomy Really Needed? A Critical Reappraisal 15 Years After the Introduction of Laparoscopic Cholecystectomy显示文摘 | George H. Sakorafas Dimitrios Milingos George Peros | 2007 | Digestive Diseases and Sciences2007，，5： | 2 |
| 10 | Mechanisms and Natural History of Pain in Chronic Pancreatitis: A Surgical Perspective显示文摘 | George H. Sakorafas Adelais G. Tsiotou George Peros | 2007 | Journal of Clinical Gastroenterology2007，，7： | 2 |
| 11 | Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center 显示文摘 | Diaz E M Jr Johnigan R H 3rd Pero C | 2005 | Head Neck2005，27，2： | 1 |
| 12 | The impact of multihop wireless channel on TCP performance显示文摘 | Fu Zhenghua Luo Haiyun Peros zerfos | 2005 | IEEE Transactions on Mobile Computing2005，4，2： | 1 |
| 13 | Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study显示文摘 | Seidgard J Pero RW Markowitz MM | 1990 | Carcinogenesis1990，11，： | 1 |
| 14 | Lymphoedema following xillary lymph node dissection for breast cancer显示文摘 | Sakorafas G H Peros G Cataliotti L | 2006 | Surg Oncol2006，15，3： | 1 |
| 15 | Asymptomatic Cholelithiasis: Is Cholecystectomy Really Needed? A Critical Reappraisal 15 Years After the Introduction of Laparoscopic Cholecystectomy显示文摘 | George H. Sakorafas Dimitrios Milingos George Peros | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 16 | Combination treatmentwith Grb7 peptide and Doxorubicin or Trastuzumab(Herceptin)results in cooperative cell growth inhibition in breast cancer cells显示文摘 | Pero SC Shukla GS Cookson MM | 2007 | Br J Cancer2007，96，10： | 1 |
| 17 | An exploratory study of the relation between supply chain topological features and supply chain performance显示文摘 | Margherita Pero Tommaso Rossi Carlo Noe Andrea Sianesi | 2012 | Intemational Joumal of Production Economics2012，，2： | 1 |
| 18 | Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells显示文摘 | Tiziana Angrisano Francesca Lembo Silvia Peluso Simona Keller Lorenzo Chiariotti Raffaela Pero | 2012 | Medical Microbiology and Immunology2012，，： | 1 |
| 19 | Oxidative stress induces DNA damage and inhibits the repair of DNA lesions induced by N-acetylaminofluorene in human peripheral mononulear leukocytes显示文摘 | Pero RW Anderson MW Anna CH | 1990 | Cancer Res1990，50，15： | 1 |
| 20 | RFID technology for increasing visibility in ETO supply chains:a ease study显示文摘 | PERO M ROSSI T | 2014 | Production Planning & Control2014，25，11： | 1 |
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