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| 1 | Regulation of the timing of oligodendrocyte differentiation:mechanisms and perspectives显示文摘Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation. | Hao Huang Xiao-Feng Zhao Kang Zheng Mengsheng Qiu | 2013 | Neuroscience Bulletin2013，29，2： | 9 |
| 2 | MYRF:A Mysterious Membrane-bound Transcription Factor Involved in Myelin Development and Human Diseases显示文摘The myelin regulatory factor gene(MYRF)encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor(MBTF).In vertebrates,MYRF protein is required for myelin development and maintenance[1,2]. | Hao Huang Fang Zhou Shiyou Zhou Mengsheng Qiu | 2021 | Neuroscience Bulletin2021，37，6： | 2 |
| 3 | AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination显示文摘Oligodendrocytes(OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK(apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYKdeficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs. | Chunxia Jiang Wanqing Yang Zhihong Fan Peng Teng Ruyi Mei Junlin Yang Aifen Yang Mengsheng Qiu Xiaofeng Zhao | 2018 | Neuroscience Bulletin2018，34，3： | 2 |
| 4 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 5 | Blending chitin to improve permeability of PU coated fabrics 显示文摘 | Mengsheng Y | 1996 | Journal of Coated Fabrics1996，，10： | 1 |
| 6 | Development of an ontology-based expert recommendation system for product empirical knowledge consultation显示文摘 | CHEN Y J CHEN Y M WU Mengsheng | | 0，，03： | 1 |
| 7 | Devel- opent of an Ontology Based Expet Recommendanda- tion System for Product Empirical Knowlede Consul- tation显示文摘 | Chen Y J Chen Y M Wu Mengsheng | 2010 | Concurrent Engineering: Research and Appli- vations2010，18，03： | 1 |
| 8 | Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling显示文摘Dear Editor,Although various components of the Wnt/β-catenin pathway have been investigated,there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation.For instance,theΔExon3 mutation ofβ-catenin[1-4],which stabilizesβ-catenin by deletion of the phosphorylation site for the destruction complex,signifi cantly inhibits the differentiation of oligodendrocytes, | Shuhui Sun Wei Guo Zunyi Zhang Mengsheng Qiu Zhong-Min Dai | 2015 | Neuroscience Bulletin2015，31，2： | 1 |
| 9 | Chemical identification of N-acyl homoserine lactone quorum-sensing signals produced by Sinorhizobium meliloti strains in defined medium显示文摘 | Max Teplitski Anatol Eberhard Matthew R. Gronquist Mengsheng Gao Jayne B. Robinson Wolfgang D. Bauer | 2003 | Archives of Microbiology2003，，6： | 1 |
| 10 | Genetic Evidence that Dorsal Spinal Oligodendrocyte Progenitor Cells are Capable of Myelinating Ventral Axons Effectively in Mice显示文摘In the developing spinal cord,the majority of oligodendrocyte progenitor cells(OPCs)are induced in the ventral neuroepithelium under the control of the Sonic Hedgehog(Shh)signaling pathway,whereas a small subset of OPCs are generated from the dorsal neuroepithelial cells independent of the Shh pathway.Although dors allyderived OPCs(dOPCs)have been shown to participate in local axonal myelination in the dorsolateral regions during development,it is not known whether they are capable of migrating into the ventral region and myelinating ventral axons.In this study,we confirmed and extended the previous study on the developmental potential of dOPCs in the absence of ventrally-derived OPCs(vOPCs).In NestinSmo conditional knockout(cKO)mice,when ventral oligodendrogenesis was blocked,dOPCs were found to undergo rapid amplification,spread to ventral spinal tissue,and eventually differentiated into myelinating OLs in the ventral white matter with a temporal delay,providing genetic evidence that dOPCs are capable of myelinating ventral axons in the mouse spinal cord. | Minxi Fang Qian Yu Baiyan Ou Hao Huang Min Yi Binghua Xie Aifen Yang Mengsheng Qiu Xiaofeng Xu | 2020 | Neuroscience Bulletin2020，36，12： | 1 |
| 11 | TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway显示文摘Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells(OPCs).TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway. | Yidan Chen Ruyi Mei Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao | 2015 | Neuroscience Bulletin2015，31，5： | 1 |
| 12 | Immunological Markers for Central Nervous System Glia显示文摘Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and microglia.They contribute more than half of the total cells of the CNS,and are essential for neural development and functioning.Studies on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular markers.However,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible confusion.Here,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression. | Hao Huang Wanjun He Tao Tang Mengsheng Qiu | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
| 13 | Cracking the Codes of Cortical Glial Progenitors:Evidence for the Common Lineage of Astrocytes and Oligodendrocytes显示文摘During the development of the central nervous system(CNS),neuroepithelial cells in the ventricular zone are multipotent stem cells that can generate neurons and macroglia(astrocytes or oligodendrocytes).It is generally thought that these progenitor cells sequentially produce neurons followed by glia. | Hao Huang John LRubenstein Mengsheng Qiu | 2021 | Neuroscience Bulletin2021，37，4： | 1 |
| 14 | Modulation of S inorhizobium meliloti quorum sensing by Hfq ‐mediated post‐transcriptional regulation of ExpR显示文摘 | Mengsheng Gao Ming Tang Lois Guerich Isai Salas‐Gonzalez Max Teplitski | 2015 | Environmental Microbiology Reports2015，，： | 1 |
| 15 | Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy显示文摘Metal-organic frameworks(MOFs)have recently allured a variety of concern in the fields of nanotechnology.However,exploring their biomedical applications is still a relatively new field.In this work,zeolite imidazole skeleton-8(ZIF-8)was reported for the first time as a drug carrier for the treatment of lung injury.Uniform ZIF-8 nanoparticles encapsulating plumbagin(PLB)are achieved by a facile physical adsorption process.Scanning electron microscopy(SEM),powder X-ray diffraction(PXRD)and UV–vis absorption spectrum were conducted to investigate the physical properties of ZIF-8 and PLB@ZIF-8.In animal model,the collagen fibers deposition produced by severe lung injury is significantly decreased.The secretion of inflammatory factor TGF-βand IL-6 were efficiently dropped by the combination of plumbagin and ZIF-8.At the same time,the expressions of collagen I,α-SMA and TNF-αwere also suppressed.This strategy puts forth a promising blueprint in the application of MOF materials,especially in biomedical fields. | Yang Wang Qing Li Mengsheng Deng Kuijun Chen Jianmin Wang | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 16 | Quorum -sensing regulation in rhizobia and its role in symbioticinteractions with legumes 显示文摘 | Maria S C Wolfgang D B Mengsheng G | 2007 | Philosophical Transac-tions of the Royal Society B : Biological Sciences2007，362，1483： | 1 |
| 17 | Research on Soil Conservation and Improvement Technology in Zhaoyang District显示文摘The environment of tobacco-growing soil directly affects the yield and quality of tobacco leaves.In order to solve problems of tobacco-growing soil degradation,low organic matter content and unbalanced soil nutrient supply and promote sustainable and healthy development of tobacco production,this paper comprehensively discussed conservation and improvement techniques of tobacco-growing soil based on existing problems in Zhaoyang District,aiming to provide reference for tobacco-growing soil conservation. | Jing YANG Shifu ZHONG Liting FANG Wei YAN Shixian PU Dianli MA Wenkai XIA Haohan GONG Mengsheng ZHANG Yeming FU Xia NI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 18 | Research on Postgraduate Classroom Construction Framework from the Perspective of Smart Education显示文摘Smart education is the future and development direction of higher education.Taking the graduate course Crime and Police Theory as the research subject,the shortcomings of smart education,which include the lack of understanding of the concept of smart education,the limited content structure of smart education,the poor cognition of smart education among teachers and students,and inadequate hardware and technical support for smart education,are systematically analyzed.In view of these shortcomings,several strategies are proposed,including improving the smart education curriculum development plan and management level,ensuring the construction quality of smart education projects,and raising funds for smart education construction from various sources. | Mengsheng Cai | 2023 | Journal of Contemporary Educational Research2023，7，3： | 0 |
| 19 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 20 | Evolution of the Nervous System Extrapolated from Ctenophore and the Resurrection of Golgi’s Reticular Theory?显示文摘For over a century,the structure and evolution of the nervous system have been at the center of debate among biologists.In the 19th century,Camillo Golgi first proposed that the nervous system is a syncytial continuum,with neurons being directly connected with shared cell membranes and cytoplasm[1].This concept is known as the reticular theory(also referred to as the syncytial theory).However,this view was later challenged by Santiago Ramon y Cajal,who put forward the neuronal doctrine[2]. | Aifen Yang Mengsheng Qiu Xiaofeng Xu | 2023 | Neuroscience Bulletin2023，39，12： | 0 |
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