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| 1 | Effects of inoculating fungi on agilawood formation in Aquilaria sinensis显示文摘Agilawood is a costly heartwood medicine obtained from Aquilaria sinensis with active ingredients mainly composed of volatile and semi-volatile substances. However, the formation time of agilawood is quite long and little is known about its formation mechanism. Two highly active fungi obtained from natural agilawood were inoculated on A. sinensis trees to understand their interaction processes and elucidate the transformation rules of induced chemical compositions within different test periods. The results demonstrated that the fungi could successfully colonize living tissues and cells and activate the host defense system, resulting in agilawood accumulation. With increasing time, the main components of A. sinensis converted into constituents or analogs of agilawood and the host exhibited 'self-injury' to prevent fungal intrusion and protect other tissues. The data presented here could provide scientific basis for producing agilawood with the two new fungi in a safe, feasible, and sustainable manner without destroying rare Aquilaria plants. | CUI JinLong GUO ShunXing FU ShaoBin XIAO PeiGen WANG MengLiang | 2013 | Chinese Science Bulletin2013，58，26： | 8 |
| 2 | Comprehensive Mineral Nutrition Analysis of Watermelon Grafted onto Two Different Rootstocks显示文摘Grafting is a widely used practice in fruit-bearing vegetables. However, why grafting affects plant growth, fruit yield, and quality, especially from the aspect of mineral nutrition, remains unclear. In this study, watermelon cultivar ‘Zaojia 8424' was grafted onto bottle gourd ‘Jingxinzhen1'(Lagenaria siceraria) and pumpkin ‘Qingyanzhen 1'(Cucurbita maxima × C. moschata). Non-grafted plants were used as the control. Results show that rootstock grafting significantly increases plant growth and single fruit weight of watermelon. Watermelon grafted onto rootstocks, especially pumpkin, exhibits significantly higher root volume, root surface area, and number of root tips and forks in comparison with non-grafted plants. Fruit flesh, rind firmness, and rind thickness were enhanced by grafting. However, fruit soluble solids and taste significantly decreased in plants grafted onto pumpkin. The total uptake(mg · plant^(-1)) and concentration(mg · g^(-1)DW) of N, K, Ca, Fe, Mg, and Mn in root, stem, leaf,fruit rind, and flesh were generally higher in grafted plants compared to non-grafted ones, especially for N of pumpkin rootstock-grafted plants.The total uptake of nutrients of plants grafted onto bottle gourd and pumpkin was increased by 30.41% and 49.14% at fruit development stage and by 21.33% and 47.46% at fruit maturation stage, respectively, compared with non-grafted plants. We concluded that watermelon grafting onto suitable rootstocks can increase the uptake of mineral nutrition, especially for N in the pumpkin rootstock grafted plants, thereby affecting plant growth, fruit yield, and quality. | HUANG Yuan ZHAO Liqiang KONG Qiusheng CHENG Fei NIU Mengliang XIE Junjun Muhammad Azher Nawaz BIE Zhilong | 2016 | Horticultural Plant Journal2016，2，2： | 7 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Comprehensive profiling of Lingzhihuang capsule by liquid chromatography coupled with mass spectrometry-based molecular networking and target prediction显示文摘Objective:Lingzhihuang capsule(LZHC)is a natural product that consists of 10 commonly used medicinal plants,and it is used in traditional Chinese medicine to promote people’s overall health.Previously,LZHC was successfully used as adjuvant therapy for treating patients with cancer.However,the chemical constituents of LZHC and their potential biological functions remain unclear.The aim of this study is to investigate the major bioactive compounds in LZHC and predict their pharmacological targets.Methods:The LZHC constituents were putatively identified by ultra-high performance liquid chromatography coupled with timeof-flight mass spectrometry combined with mass spectrometry-based molecular networking.The targets were predicted using SwissTargetPrediction software,and the associated gene ontology and Kyoto encyclopedia of genes and genomes pathways were analyzed using the Database for Annotation,Visualization,and Integrated Discovery.The mass spectrometry-based molecular network and compound-target-pathway network were constructed using Cytoscape 3.8.0 software.Results:We putatively identified 94 compounds of LZHC by mass spectrometry-based molecular networking,including triterpene(the main structural type)and other clusters(ie,flavonoids and organic acids).Our results suggested that multiple pivotal targets were regulated by LZHC,including tumor necrosis factor,nitric oxide synthase 2,glucocorticoid receptor,estrogen receptor,3-oxo-5-alpha-steroid 4-dehydrogenase 2,prostaglandin e2 receptor ep4 subtype,estrogen receptor beta,phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform,mitogen-activated protein kinase 3,and racalpha serine,which are related to signal transduction,positive regulation of transcription from RNA polymerase II promoters,oxidation-reduction processes,inflammatory responses,and other biological processes.Functional annotation of those targets suggested that several signaling pathways may be regulated by LZHC,such as cancer-related proteoglycans,the PI3K-Aktsignaling pathway,and the cAMP-signaling pathway.Conclusions:Our findings reveal the chemical constituents of LZHC and provided scientific support for the efficacy of LZHC in terms of immune regulation,anti-aging,and tumor suppression. | Mengliang Huang Sijia Yu Qing Shao Hao Liu Yingchao Wang Hongzhang Chen Yansheng Huang Yi Wang | 2022 | Acupuncture and Herbal Medicine2022，2，1： | 2 |
| 5 | Cyclosporin A ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway显示文摘 | Yuxiang Dai Qing Sun Xing Zhang Yangchun Hu Mengliang Zhou Jixin Shi | 2014 | Brain Research2014，，： | 1 |
| 6 | Preparation of SrR2O4 : Eu3+ (R = Y, Lu) phosphor and its photoluminescence properties显示文摘 | ZHOU LIYA SHI JIANXIN GONG MENGLIANG | 2005 | Mater Lett2005，59，： | 1 |
| 7 | 显示文摘 | LouWeijuan(漏卫娟) ZhangLei(张雷) MengLiang(孟亮) | 2006 | 稀有金属材料与工程2006，35，2： | 1 |
| 8 | 显示文摘 | MengLiang(孟亮) ZhangBaochang(张宝昌) | | 金属学报0，，： | 1 |
| 9 | The challenge to NO2 emission control for heavy-duty diesel vehicles in China显示文摘 | WU Ye ZHANG Shaojun LI Mengliang | 2012 | Atmospheric Chemistry and Physics2012，12，19： | 1 |
| 10 | Preparation, Charac- Lerization evaluation of Tanshinone IIA lipid microspere and compara- :ive study of pharmacokinetics with Sodium Tanshinone IIA Sulfonate injection显示文摘 | Xinli Liang Mengliang Zhu Yunchao Cao | 2013 | Advanced Materials Research Vols2013，，781784： | 1 |
| 11 | Metabolomic and network analysis of astaxanthin-producing Haematococcus pluvialis under various stress conditions显示文摘 | Yingxue Su Jiangxin Wang Mengliang Shi | 2014 | Bioresource Technology2014，，170： | 1 |
| 12 | Historic and future trends of vehicle emissions in Beijing, 1998–2020: A policy assessment for the most stringent vehicle emission control program in China显示文摘 | Shaojun Zhang Ye Wu Xiaomeng Wu Mengliang Li Yunshan Ge Bin Liang Yueyun Xu Yu Zhou Huan Liu Lixin Fu Jiming Hao | 2013 | Atmospheric Environment2013，，： | 1 |
| 13 | Effect of Rare Earth Elements on Microstructure of Cu-6% Ag and Cu-24% Ag Alloys显示文摘The cast rods of the alloys with low Ag content, Cu-6% Ag, and high Ag content, Cu-24%,were prepared and homogenized. The effect of rare earth elements on the microstructure was investigated by adding 0.1% mischmetal into the alloys. Adding minor rare earth elements to the as-cast rods produces more eutectic, finer grains of a matrix and shorter interval of dendritic arms enveloped by continuous network of eutectic structure Duringhomogenization treatment, the alloys contained with the rare earth elements make the secondary phase finer in the a matrix and have a significant tendency to make the eutectic structure more dispersed and divorced morphology. | LiZhenduo ZhangLei MengLiang | 2005 | Journal of Rare Earths2005，23，3： | 1 |
| 14 | Analysis of synonymous codon usage in Zea mays显示文摘 | Hanmei Liu Rui He Huaiyu Zhang Yubi Huang Mengliang Tian Junjie Zhang | 2010 | Molecular Biology Reports2010，，2： | 1 |
| 15 | Accumulation and Distribution Dynamics of Soluble Carbohydrate in Helianthus tuberosus under Drought Stress显示文摘With Qingyu 1 and Qingyu 2 as test materials,variation of soluble carbohydrate content in different parts were studied under two types of artificially simulated drought stress( polyethylene glycol PEG-6000 stress and water-controlling stress). The results showed that under the stress of PEG,soluble carbohydrate content in leaves of Qingyu 1 and Qingyu 2 increased with the prolonging time of stress; soluble carbohydrate content in stems of Qingyu 1 did not show regular changes with the prolonging time of stress,while 30% PEG stress received the best effect on Qingyu 2 after 24h; soluble carbohydrate content in roots of Qingyu 1 and Qingyu 2 increased with the prolonging time of stress. Under different intensities of water-controlling stress,soluble carbohydrate content in leaves of Qingyu 1 first increased then decreased,while that in leaves of Qingyu 2 increased; soluble carbohydrate content in stems of Qingyu 1 and Qingyu 2 increased with the prolonging time of water-controlling stress; soluble carbohydrate content in roots of Qingyu 1 decreased with the prolonging time of water-controlling stress,while that in roots of Qingyu 2 differed slightly. | Zhao Mengliang Wang Lihui Sun Xuemei Li Yi Li Li | 2016 | Plant Diseases and Pests2016，7，1： | 1 |
| 16 | Design and Optimization of a Low-Noise Voltage Reference Using Chopper Stabilization Technique显示文摘A low-noise voltage reference is presented to enhance resolution of MEMS capacitive accelerometer and reduce system noise,in which the circuit uses Chopper stabilization(CHS) technique for the suppression of low-frequency noise.A 3.7V voltage reference chip is fabricated in a 0.5-μm CMOS process.Compared with the voltage reference without using CHS,the proposed design is much more superior in low-noise performance.Experimental results indicate that the output noise of reference voltage V RP can reach 0.121μV/sqrt(Hz) at the vicinity of 3 Hz. | PENG Lingjie JIN Xiangliang LIU Mengliang | 2017 | Chinese Journal of Electronics2017，26，5： | 1 |
| 17 | 显示文摘 | MENGLiang(孟梁) WANGYan-yan(王燕燕) MENGPin-jia(孟品佳) WANGYan-ji(王彦吉) ZHANGQiang(张强) | | ChineseJAnalChem0，，： | 1 |
| 18 | Historic and future trends of vehicle emissions in Beijing, 1998–2020: A policy assessment for the most stringent vehicle emission control program in China显示文摘 | Shaojun Zhang Ye Wu Xiaomeng Wu Mengliang Li Yunshan Ge Bin Liang Yueyun Xu Yu Zhou Huan Liu Lixin Fu Jiming Hao | 2013 | Atmospheric Environment2013，，： | 1 |
| 19 | Variability of fuel consumption and CO_(2) emissions of a gasoline passenger car under multiple in-laboratory and on-road testing conditions显示文摘An increasing divergence regarding fuel consumption(and/or CO_(2)emissions) between realworld and type-approval values for light-duty gasoline vehicles(LDGVs) has posed severe challenges to mitigating greenhouse gases(GHGs) and achieving carbon emissions peak and neutrality. To address this divergence issue, laboratory test cycles with more real-featured and transient traffic patterns have been developed recently, for example, the China Lightduty Vehicle Test Cycle for Passenger cars(CLTC-P). We collected fuel consumption and CO_(2)emissions data of a LDGV under various conditions based on laboratory chassis dynamometer and on-road tests. Laboratory results showed that both standard test cycles and setting methods of road load affected fuel consumption slightly, with variations of less than 4%. Compared to the type-approval value, laboratory and on-road fuel consumption of the tested LDGV over the CLTC-P increased by 9% and 34% under the reference condition(i.e., air conditioning off, automatic stop and start(STT) on and two passengers). On-road measurement results indicated that fuel consumption under the low-speed phase of the CLTC-P increased by 12% due to the STT off, although only a 4% increase on average over the entire cycle. More fuel consumption increases(52%) were attributed to air conditioning usage and full passenger capacity. Strong correlations(R2> 0.9) between relative fuel consumption and average speed were also identified. Under traffic congestion(average speed below 25 km/hr), fuel consumption was highly sensitive to changes in vehicle speed. Thus,we suggest that real-world driving conditions cannot be ignored when evaluating the fuel economy and GHGs reduction of LDGVs. | Boya Zhou Liqiang He Shijian Zhang Rui Wang Luowei Zhang Mengliang Li Yu Liu Shaojun Zhang Ye Wu Jiming Hao | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 20 | Exploiting Complex-Type N-Glycan to Improve the in Vivo Stability of Bioactive Peptides显示文摘Peptides can be potentmolecules with high efficacy and selectivity in the development of biotherapeutics.However,the poor pharmacokinetic properties of peptides pose major challenges for their broader medicinal applications.Inspired by the proteinstabilizing role of natural N-glycosylation,we design and synthesize a series of parathyroid hormone(PTH)peptides(1-34),bearing either N-GlcNAc or biantennary complex-type N-glycan modification,and evaluate their serum stability and biological activities.The results indicate that an N-Asn-linked complex-type sialylundecasaccharide can increase the serum half-life and in vivo bioactivity of PTH peptides with a broad tolerance of modification sites.Further,hydrogen/deuterium exchange mass spectroscopy indicates that the larger-sized Nglycan can induce enhanced hydration dynamics in its surroundings,which may facilitate an improved resistance for the peptide against enzymatic proteolysis.This sialylundecasaccharide-based peptideengineering strategy has also been applied to glucagon-like peptide-1(7-37),leading to glycopeptides with enhanced hypoglycemic activity and acting time in vivo.Together,these results demonstrate the potential of using sialylated complextype N-glycan as a general engineering strategy for developing long-acting peptide therapeutics. | Qijia Wei Jun Zhang Yuankun Dao Mengliang Ye Dangliang Liu Weidong Dong Ning Yuan Hongxing Li Chunli Song Mo Li Xiaomeng Shi Suwei Dong | 2023 | CCS Chemistry2023，5，7： | 0 |
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