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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Accumulation and potential sources of heavy metals in soils of the Hetao area,Inner Mongolia,China显示文摘Soil contamination by heavy metals is a problem in agricultural irrigation systems.To assess the accumulation and sources of heavy metals in the Yongji irrigation district of the Hetao area,Inner Mongolia,China,195 soil samples from 39 sites(0–100 cm)were collected,and Zn,Cu,Pb,Cr,and Cd concentrations were analyzed.The mean concentrations were 107.17,32.48,12.31,53.53,and 0.22 mg kg-1,respectively,with no significant differences between soil depths(P>0.05).Concentrations of Zn,Cu,and Cd were higher than the background levels,with moderate accumulation;the contamination factor(CF)values were 1.9,1.7,and 1.9,respectively,and the geoaccumulation index(Igeo)was>0.Concentrations of Pb and Cr were lower than,or close to,the background levels(CF<1,Igeo<0),indicating that they originated from a natural source.The monomial potential ecological risk index(Eri)for Zn,Cu,Pb,and Cr was low;Eri for Cd was 55.73,implying a moderate risk.The grade of potential ecological risk index of the five heavy metals(RI)was low,declining from south to north.The studied soils were contaminated with Zn,Cu,and Cd;principal component(PC)analysis implicated the enrichment of Cd and partial Cu(high loading in PC 2)was related to agricultural activities;Zn and partial Cu,closely associated with PC 3,may have originated from irrigation water from the Yellow River.Future agricultural development should focus on fertilizer and pesticide application and the quality of irrigation water. | Yangchun ZHU Lijin WANG Xueyong ZHAO Jie LIAN Zhenhua ZHANG | 2020 | Pedosphere2020，30，2： | 12 |
| 3 | Artificial root exudates and soil organic carbon mineralization in a degraded sandy grassland in northern China显示文摘Plant root exudates contain various organic and inorganic components that include glucose, citric and oxalic acid. These components affect rhizosphere microbial and microfaunal activities, but the mechanisms are not fully known. Studies concerned from degraded grassland ecosystems with low soil carbon(C) contents are rare, in spite of the global distribution of grasslands in need of restoration. All these have a high potential for carbon sequestration, with a reduced carbon content due to overutilization. An exudate component that rapidly decomposes will increase soil respiration and CO2 emission, while a component that reduces decomposition of native soil carbon can reduce CO2 emission and actually help sequestering carbon in soil. Therefore, to investigate root exudate effects on rhizosphere activity, citric acid, glucose and oxalic acid(0.6 g C/kg dry soil) were added to soils from three biotopes(grassland, fixed dune and mobile dune) located in Naiman, Horqin Sandy Land, Inner Mongolia, China) and subjected to a 24-day incubation experiment together with a control. The soils were also analyzed for general soil properties. The results show that total respiration without exudate addition was highest in grassland soil, intermediate in fixed dune and lowest in mobile dune soil. However, the proportion of native soil carbon mineralized was highest in mobile dune soil, reflecting the low C/N ratio found there. The exudate effects on CO2-C emissions and other variables differed somewhat between biotopes, but total respiration(including that from the added substrates) was significantly increased in all combinations compared with the control, except for oxalic acid addition to mobile dune soil, which reduced CO2-C emissions from native soil carbon. A small but statistically significant increase in pH by the exudate additions in grassland and fixed dune soil was observed, but there was a major decrease from acid additions to mobile dune soil. In contrast, electrical conductivity decreased in grassland and fixed dune soil and increased in mobile dune. Thus, discrete components of root exudates affected soil environmental conditions differently, and responses to root exudates in soils with low carbon contents can differ from those in normal soils. The results indicate a potential for, e.g., acid root exudates to decrease decomposition rate of soil organic matter in low carbon soils, which is of interest for both soil restoration and carbon sequestration. | YongQing LUO XueYong ZHAO Olof ANDRéN YangChun ZHU WenDa HUANG | 2014 | Journal of Arid Land2014，6，4： | 11 |
| 4 | Effects of fumaric acid supplementation on methane production and rumen fermentation in goats fed diets varying in forage and concentrate particle size显示文摘Background: In rumen fermentation, fumaric acid(FA) could competitively utilize hydrogen with methanogenesis to enhance propionate production and suppress methane emission, but both effects were diet-dependent. This study aimed to explore the effects of FA supplementation on methanogenesis and rumen fermentation in goats fed diets varying in forage and concentrate particle size.Methods: Four rumen-cannulated goats were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments: low or high ratio of forage particle size: concentrate particle size(Fps:Cps), without or with FA supplementation(24 g/d). Fps:Cps was higher in the diet with chopped alfalfa hay plus ground corn than in that with ground alfalfa hay plus crushed corn.Results: Both increasing dietary Fps:Cps and FA supplementation shifted ruminal volatile fatty acid(VFA) patterns toward more propionate and less acetate in goats. An interaction between dietary Fps:Cps and FA supplementation was observed for the ratio of acetate to propionate(A:P), which was more predominant when FA was supplemented in the low-Fps:Cps diet. Methane production was reduced by FA, and the reduction was larger in the low-Fps:Cps diet(31.72%) than in the high-Fps:Cps diet(17.91%). Fumaric acid decreased ruminal total VFA concentration and increased ruminal p H. No difference was found in ruminal DM degradation of concentrate or alfalfa hay by dietary Fps:Cps or FA. Goats presented a lower ruminal methanogen abundance with FA supplementation and a higher B. fibrisolvens abundance with high dietary Fps:Cps.Conclusions: Adjusting dietary Fps:Cps is an alternative dietary model for studying diet-dependent effects without changing dietary chemical composition. Fumaric acid supplementation in the low-Fps:Cps diet showed greater responses in methane mitigation and propionate increase. | Zongjun Li Nannan Liu Yangchun Cao Chunjia Jin Fei Li Chuanjiang Cai Junhu Yao | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 8 |
| 5 | Load Bearing Capacity and Safety Analysis for Strain-hardening Austenitic Stainless Steel Pressure Vessels显示文摘By increasing the yield strengths of austenitic stainless steels for pressure vessels with strain hardening techniques,the elastic load bearing capacity of austenitic stainless steel pressure vessels can be significantly improved.Two kinds of strain hardening methods are often used for austenitic stainless steel pressure vessels:Avesta model for ambient temperature applications and Ardeform model for cryogenic temperature applications.Both methods are obtained from conventional design rules based on the linear elastic theory,and only consider the hardening effect from materials.Consequently this limits the applications of strain hardening techniques for austenitic stainless steel pressure vessels because of safety concerns.This paper investigates the effect of strain hardening on the load bearing capacity of austenitic stainless steel pressure vessels under large deformation,based on the elastic-plastic theory.Firstly,to understand the effect of strain hardening on material behavior,the plastic instability loads of a round tensile bar specimen are derived under two different loading paths and validated by experiments.Secondly,to investigate the effect of strain hardening on pressure vessels strength, the plastic instability pressure under strain hardening is derived and further validated by finite element simulations.Further,the safety margin of pressure vessels after strain hardening is analyzed by comparing the safety factor values calculated from bursting tests,finite element analyses,and standards.The researching results show that the load bearing capacity of pressure vessels at ambient temperature is independent of the loading history when the effects of both material strain hardening and structural deformation are considered.Finite element simulations and bursting tests results show that the minimum safety factor of austenitic stainless steel pressure vessels with 5% strain hardening is close to the recommended value for common pressure vessels specified in the European pressure vessel standard.The proposed study also shows that in the strain hardening design of austenitic stainless steel pressure vessels,the calculation for plastic instability pressure could use theoretical formula or finite element analyses based on geometrical dimensions and material property parameters before strain hardening,but a 5%strain should be employed as a design limit.The proposed research can be used for the strain hardening design of austenitic stainless steel pressure vessels safely. | CHEN Gang DENG Yangchun | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 7 |
| 6 | Floral traits and pollination system of Zygophyllum xanthoxylum in the managed and wild populations in an arid region of Northwest China显示文摘Zygophyllum xanthoxylum, which belongs to Sarcozygium of Zygophyllaceae, is one of the ecologically important species in Northwest China. In order to understand the pollination system of Z. xanthoxylum, we investigated the following characteristics of this species in the Urat Desert-grassland Research Station in western Inner Mongolia of China: flowering dynamics, pollen viability, pollen limitation, floral visitors and breeding system. The results showed that the flowering period and flowering peak were different between the wild and managed populations, being longer in the managed population. Z. xanthoxylum was pollen-limited, and pollen limitation was more intense in the wild population than in the managed population. Chalicodoma deserticola(Hymenoptera) was found to be the most frequent pollinator in the wild population, while Anthophora fulvitarsis(Hymenoptera) was the most frequent and effective visitor in the managed population. Out-crossing was dominant in the breeding system and self-pollination just played an assistant role to assure the reproduction of Z. xanthoxylum. | CHEN Min ZHAO Xueyong ZUO Xiao'an LIAN Jie ZHU Yangchun | 2015 | Journal of Arid Land2015，7，4： | 7 |
| 7 | Nano-scaled iron-carbon precipitates in HSLC and HSLA steels显示文摘This paper studies the composition, quantity and particle size distribution of nano-scaled precipitates with size less than 20 nm in high strength low carbon (HSLC) steel and their effects on mechanical properties of HSLC steel by means of mass balance calculation of nano-scaled precipitates measured by chemical phase analysis plus SAXS method, high-resolution TEM analysis and thermodynamics calculation, as well as temper rapid cooling treatment of ZJ330. It is found that there existed a large quantity of nano-scaled iron-carbon precipitates with size less than 18 nm in low carbon steel produced by CSP and they are mainly Fe-O-C and Fe-Ti-O-C precipitates formed below temperature A1. These precipitates have ob- vious precipitation strengthening effect on HSLC steel and this may be regarded as one of the main reasons why HSLC steel has higher strength. There also existed a lot of iron-carbon precipitates with size less than 36 nm in HSLA steels. | FU Jie WU HuaJie LIU YangChun KANG YongLin | 2007 | Science China(Technological Sciences)2007，50，2： | 6 |
| 8 | Optimized design and performance evaluation of an electric cup-chain potato metering device显示文摘The cup-chain metering device is commonly used in potato planters despite its problems of missing-seeding,double-seeding and ground wheel sliding.A mechanical-electrical design was developed for planters to resolve these problems.A regression experiment was conducted with three factors(chain speed,chain tightening distance and cup tilting)and two indicators(missing-seeding rate and double-seeding rate).Based on the results of regression experiment,a numerical regression model was built and a multi-objective optimization method was used to get an optimal solution.Subsequently,the optimized device was tested in the field.The device design presents a tilting seed cup with a guard plate and an electric control system.The laboratory test showed that the missing-seeding rate increased with the chain speed.It initially decreases and then increases with the chain tightening distance and cup tilting angle.The double-seeding rate declines with chain speed.It increases initially and declines afterward with the chain tightening distance.The optimization resulted in a missing-seeding rate of 4.39%and a double-seeding rate of 8.78%under the parameters of 0.32 m/s seeding speed,0.94×10-3 m tightening distance,and 12.5°cup tilting angle.The field test demonstrated that electric control instead of ground wheel-driven chain enables fast seeding and precise intra-row seeding distance. | Niu Kang Fang Xianfa Liu Yangchun Lü Chengxu Yuan Yanwei | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 5 |
| 9 | Effect of dietary supplementation with sugar cane extract on meat quality and oxidative stability in finishing pigs显示文摘The aim of the present study was to investigate the effect of dietary supplementation with sugar cane extract(SCE) on meat quality and oxidative stability of Longissimus dorsi muscle in finishing pigs.Eighteen barrows(Duroc × Landrace × Jiaxing Black), with an average initial body weight of 62.1 ± 5.0 kg,were randomly allotted to 1 of 3 diets with 6 replicates per treatment for 42 days. The diets comprised a normal diet and the normal diets supplemented with 5 and 25 g/kg SCE. The results showed that SCE supplementation did not affect final body weight of finishing pigs. Dietary SCE supplementation significantly increased(P < 0.05) Longissimus dorsi muscle pH_(24 h),and tended to reduce(P < 0.1) and significantly decreased(P < 0.05) shear force, drip loss, myofiber cross sectional area and lactate dehydrogenase activity at 5 and 25 g/kg, respectively. Meanwhile, dietary SCE treatments significantly decreased(P < 0.05) malonaldehyde content and total superoxide dismutase activity in Longissimus dorsi muscle, and tended to reduce(P < 0.1) malonaldehyde content in serum. Altogether, these data indicate that SCE is an effective feed additive to improve pork meat quality, and the underlying mechanism may be partly due to the improved oxidative stability induced by dietary SCE supplementation. | Yangchun Xia Yansen Li Xiangxing Shen Massami Mizu Toma Furuta Chunmei Li | 2017 | Animal Nutrition2017，，3： | 5 |
| 10 | Effects of preventive acupuncture or moxibustion at the Guanyuan acupoint on expression of interleukin-2 and its receptors in hypothalamus, serum, and uterus of menopausal rats显示文摘BACKGROUND: Previous studies have indicated preventive acupuncture and moxibustion at the Guanyuan point have positive effects on the immune system of menopausal rats. OBJECTIVE: To observe the effects of preventive acupuncture or moxibustion at the Guanyuan point on interleukin-2 (IL-2) and its receptor (IL-2R mRNA) levels in hypothalamus, serum, and uterus of menopausal rats. DESIGN: Randomized control animal experiment. SETTING: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine. MATERIALS: This study was performed at the Laboratory of Beijing University of Chinese Medicine from November 2004 to July 2005. The vaginal smear method was used to determine the estrus cycle of 9.5-month-old Sprague Dawley (SD) female rats. Three continuous estrus cycles were measured, and 160 rats with estrus cycle disorder, weighing (300 ± 20) g, were included in this study. The rats were randomly divided into four groups: preventive acupuncture group (n =48), preventive moxibustion group (n =48), model groups (n =48), and 10-month-old group (n =16). Sixteen 3.5-month-old healthy SD female rats, weighing (240 ± 20) g, were also assigned to the young group. All rats were clean grade and were purchased from the Laboratory Animal Center, Beijing University of Chinese Medicine. The experiment was in accordance with animal ethics standards. METHODS: Acupuncture was applied to the preventive acupuncture group at 10 months of age. The needle was inserted upward and perpendicularly two fen to a point that was two fen below the Guanyuan point. The rats freely moved around during needle retention (20 minutes). Acupuncture was administered twice a week and continued for eight weeks. A moxa cone (small) moxibustion was applied to the preventive moxibustion group at 10 months of age. The rats were caught gently and kept at the same position as the preventive acupuncture group. The moxa cone was ignited and held to the Guanyuan point directly. Only one moxa cone was used each time. After moxibustion, the local skin turned slightly red. Moxibustion was used twice a week and continued for eight weeks. Nothing except gently catching and lying was administered to the model group and the young group. MAIN OUTCOME MEASURES: Radioimmunoassay, in situ hybridization, and similar methods were employed to detect IL-2 in serum and the uterus, as well as IL-2R mRNA expression in the hypothalamus and uterus arcuate nuclei, of the preventive acupuncture group, preventive moxibustion group, model groups (at 12, 14, and 16 months), 10 month old group (at 10 months), and the young group (at 4 months). RESULTS: All 176 rats were included in the final analysis. ① IL-2R mRNA: IL-2R mRNA expression decreased significantly in the uterus of 12-, 14-, and 16-month-old model groups and in the hypothalamus of 14- and 16-month-old model groups (P < 0.05-0.01). Compared to the same month-aged model groups, the expression of IL-2R mRNA increased significantly in the hypothalamus and uterus of 16-month-old preventive acupuncture or moxibustion groups (P < 0.05-0.01).② IL-2: IL-2 in serum of 12- and 14-month-old model groups and in the uterus of 12-, 14-, and 16-month-old model groups decreased significantly compared to the young group (P < 0.05-0.01). IL-2 serum levels increased significantly in the 16-month-old group with preventive moxibustion; in addition, IL-2 expression levels increased significantly in the uterus of the 12-month-old group with preventive moxibustion, as well as the 12- and 16-month-old groups with preventive acupuncture (P < 0.05-0.01). CONCLUSION: As a rat ages and becomes menopausal, IL-2R mRNA expression in the hypothalamus anduterus, as well as IL-2 levels in the serum and uterus, decrease. However, preventive acupuncture and preventive moxibustion can repress the decrease to some extent. This effect is even greater in the late stages of menopause (16-month-old rats). | Xiaohong Li Yuwei He Jieping Xie Lufen Zhang Dengfang Zhou Jinghui Zhai Rui Zhan Jun Zhou Limin Qu Yangchun Tian | 2008 | Neural Regeneration Research2008，3，1： | 5 |
| 11 | High rumen degradable starch decreased goat milk fat via trans-10,cis-12 conjugated linoleic acid-mediated downregulation of lipogenesis genes,particularly,INSIG1显示文摘Background:Starch is an important substance that supplies energy to ruminants.To provide sufficient energy for high-yielding dairy ruminants,they are typically fed starch-enriched diets.However,starch-enriched diets have been proven to increase the risk of milk fat depression(MFD)in dairy cows.The starch present in ruminant diets could be divided into rumen-degradable starch(RDS)and rumen escaped starch(RES)according to their different degradation sites(rumen or intestine).Goats and cows have different sensitivities to MFD.Data regarding the potential roles of RDS in milk fat synthesis in the mammary tissue of dairy goats and in regulating the occurrence of MFD are limited.Results:Eighteen Guanzhong dairy goats(day in milk=185±12 d)with similar parity,weight,and milk yield were selected and randomly assigned to one of three groups(n=6),which were fed an LRDS diet(Low RDS=20.52%),MRDS diet(Medium RDS=22.15%),or HRDS diet(High RDS=24.88%)for 5 weeks.Compared with that of the LRDS group,the milk fat contents in the MRDS and HRDS groups significantly decreased.The yields of short-,mediumand long-chain fatty acids decreased in the HRDS group.Furthermore,increased RDS significantly decreased ruminal B.fibrisolvens and Pseudobutyrivibrio abundances and increased the trans-10,cis-12 conjugated linoleic acid(CLA)and trans-10 C18:1 contents in the rumen fluid.A multiomics study revealed that the HRDS diet affected mammary lipid metabolism down-regulation of ACSS2,MVD,AGPS,SCD5,FADS2,CERCAM,SC5D,HSD17B7,HSD17B12,ATM,TP53RK,GDF1 and LOC102177400.Remarkably,the significant decrease of INSIG1,whose expression was depressed by trans-10,cis-12 CLA,could reduce the activity of SREBP and,consequently,downregulate the downstream gene expression of SREBF1.Conclusions:HRDS-induced goat MFD resulted from the downregulation of genes involved in lipogenesis,particularly,INSIG1.Specifically,even though the total starch content and the concentrate-to-fiber ratio were the same as those of the high-RDS diet,the low and medium RDS diets did not cause MFD in lactating goats. | Lixin Zheng Shengru Wu Jing Shen Xiaoying Han Chunjia Jin Xiaodong Chen Shengguo Zhao Yangchun Cao Junhu Yao | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 4 |
| 12 | Dynamics of methanogenesis,ruminal fermentation and fiber digestibility in ruminants following elimination of protozoa: a meta-analysis显示文摘Background: Ruminal microbes are vital to the conversion of lignocellulose-rich plant materials into nutrients for ruminants.Although protozoa play a key role in linking ruminal microbial networks,the contribution of protozoa to rumen fermentation remains controversial; therefore,this meta-analysis was conducted to quantitatively summarize the temporal dynamics of methanogenesis,ruminal volatile fatty acid(VFA) profiles and dietary fiber digestibility in ruminants following the elimination of protozoa(also termed defaunation).A total of 49 studies from 22 publications were evaluated.Results: The results revealed that defaunation reduced methane production and shifted ruminal VFA profiles to consist of more propionate and less acetate and butyrate,but with a reduced total VFA concentration and decreased dietary fiber digestibility.However,these effects were diminished linearly,at different rates,with time during the first few weeks after defaunation,and eventually reached relative stability.The acetate to propionate ratio and methane production were increased at 7 and 11 wk after defaunation,respectively.Conclusions: Elimination of protozoa initially shifted the rumen fermentation toward the production of more propionate and less methane,but eventually toward the production of less propionate and more methane over time. | Zongjun Li Qi Deng Yangfan Liu Tao Yan Fei Li Yangchun Cao Junhu Yao | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 13 | Particle size distributions, PM2.5 concentrations and water- soluble inorganic ions in different public indoor environments: a case study in Jinan, China显示文摘In this study, we collected particles with aerodynamic diameter≤2.5μm (PM2.5) from three different public indoor places (a supermarket, a commercial office, and a university dining hall) in Jinan, a medium-sized city located in northern China. Water- soluble inorganic ions of PM2.5 and particle size distributions were also measured. Both indoor and outdoor PM2.5 levels (102.3-143.8 μg·m- 3 and 160.2-301.3 μg·m-3, respectively) were substantially higher than the value recommended by the World Health Organization (25 I.μg·m-3), and outdoor sources were found to be the major contributors to indoor pollutants. Diurnal particle number size distributions were different, while the maximum volume concentrations all appeared to be approximately 300nm in the three indoor locations. Concentrations of indoor and outdoor PM2.5 were shown to exhibit the same variation trends for the supermarket and dining hall. For the office, PM2.5 concentrations during nighttime were observed to decrease sharply. Among others, SO4^2-, NH4+ and NO3- were found to be the dominant water-soluble ions of both indoor and outdoor particles. Concentrations of NO3- in the supermarket and office during the daytime were observed to decrease sharply, which might be attributed to the fact that the indoor temperature was much higher than the outdoor temperature. In addition, domestic activities such as cleaning, water usage, cooking, and smoking also played roles in degraded indoor air quality. However, the results obtained here might be negatively impacted by the small number of samples and short sampling durations. | Can DONG Lingxiao YANG Chao YAN Qi YUAN Yangchun YU Wenxing WANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 3 |
| 14 | Characteristics of high arsenic groundwater in Hetao Basin,Inner Mongolia,northern China显示文摘It is well known that the Hetao Basin is one of the most seriously arsenic-affected groundwater areas in China. In order to understand the characteristics of high arsenic(As) groundwater in the Basin, a brief overview of arsenic in groundwater follows. High arsenic in the Basin commonly occurs in shallow groundwater and the total arsenic concentrations range from 0.58 to 572 μg/L(average 99.73 μg/L), exceeding the maximum mandated value of 10 μg/L for drinking water in China; As(Ш) is the predominant species. The regional distribution pattern of arsenic in the groundwater increases from south/southeast to north/northwest. Hangjinhouqi and Wuyuan counties are considered as the most seriously affected areas, with high incidences of endemic arsenicosic diseases in the Hetao Basin. High groundwater arsenic correlates with the increase of well depth. Previous studies proposed that groundwater arsenic in the Basin is mainly originated from desorption of some natural solid materials in the sediments, under reducing condition. Generally, reducing condition is believed to be the primary factor for arsenic releasing from the sediment to groundwater in the region. Under inorganic or bacterial processes, Fe2O3 changes to Fe S and arsenic adsorbed to Fe(OH)3 dissolves into groundwater, and As(V) is reduced to As(Ш). Besides, reducing environments, groundwater hydraulic gradients, organic matter, p H, evapotranspiration, and soil texture are presumed to be the predominant factors that control arsenic mobilization. | YangChun Zhu XueYong Zhao Min Chen YongQing Luo Xin Zhou | 2015 | Research in Cold and Arid Regions2015，7，1： | 2 |
| 15 | Comparison of diagnostic accuracy between ^(18)F-FDG PET and PET/CT for pulmonary neoplasm显示文摘Aimed at comparing diagnostic accuracy of 18F-FDG PET with PET/CT for pulmonary neoplasm, a study based on multi-center clinical trial of the diagnoses, in randomized and semi-blind ways, was executed from January 2006 to June 2007. It included 55 patients, i.e. 16 with histopathologically proved lung tumors, 16 with tuberculosis and 23 with benign lesions (inflammation, pseudotumor, granuloma, fibrosis and others). The histopathologic and clinic results were served as reference standard. Statistical significances in pulmonary nodule diagnosis between 18F-FDG PET and PET/CT were determined with 95% confidence interval obtained by ROC analysis. The 18F-FDG PET detected lung neoplasm with a sensitivity of 87.5% (14/16), a specificity of 59.0% (23/39), an accuracy of 67.3% (37/55) and a positive-likelihood ratio of 2.13. The 18F-FDG PET/CT detected lung neoplasm with a sensitivity of 93.8% (15/16), a specificity of 61.5% (24/39), an accuracy of 70.9% (39/55) and a positive-likelihood ratio of 2.43. The area under curves (AUC) of 18F-FDG PET and PET/CT were 0.803±0.068 and 0.799±0.063, respectively. It can be concluded that the diagnostic accuracy for malignant pulmonary nodules between 18F-FDG PET and PET/CT was not statistically different. | CHEN Yangchun CHEN Ping TIAN Jiahe CAI Xin YE Guangchun DENG Huaifu YANG Xiaofeng | 2009 | Nuclear Science and Techniques2009，20，1： | 2 |
| 16 | Recombinant human erythropoietin accelerated the proliferation of non-small cell lung cancer cell lines and reduced the expression of VEGF,HIF-1α,and PD-L1 under a simulated hypoxic environment in vitro显示文摘Background:As erythropoietin(EPO)has been used to treat anemia in cancer patients,negative controversy has continued.Unfortunately,its effects on non-small-cell lung carcinoma(NSCLC)cell lines are uncertain and the phenomenon of inducing immune escape of tumor cells remains to be explored.This study aimed to provide an important basis for the application of exogenous EPO in the treatment of tumor-associated anemia.Methods:Cells were cultured in 1%O2,5%CO_(2),and 94%N2 to simulate a hypoxic environment of the tumor.A549 cell line(lower expression EPOR)and NCI-H838 cell line(higher expression EPOR)were treated with 2 and 8 U/ml recombinant human EPO(rhEPO).CCK-8 method was used to determine the logarithmic growth phase of the cells and to detect cell proliferation.The expression levels of VEGF,HIF-1α,and PD-L1 were determined by western blot.One-way ANOVA was used for statistical analysis between groups,withp<0.05 indicating a significant difference.Results:Hypoxia itself could decrease the survival rate of NSCLC cells.Under the hypoxic condition,rhEPO induced tumor cells proliferation,especially in the NCI-H838 cell line,where 2 U/ml rhEPO increased the total number of surviving cells(Hypoxia+rhEPO 2 U/ml vs.Hypoxia,p<0.05).Western blot analysis showed that hypoxia upregulated the expression of VEGF,HIF-1α,and PD-L1 in NSCLC cell lines(Normoxia vs.Hypoxia,p<0.05),but may not be dependent on the expression levels of EPOR.RhEPO decreased the expression levels of VEGF and HIF-1α.In the A549 cell line,it depended on the concentration of rhEPO and was particularly obvious in HIF-1α(Hypoxia vs.Hypoxia+rhEPO 2 U/ml vs.Hypoxia+rhEPO 8 U/ml,p<0.05).A low concentration of rhEPO may not reduce VEGF expression.In the NCI-H838 cell line,the effect of rhEPO on VEGF was more obvious,but it may be independent of rhEPO concentrations.The downregulation of PD-L1 expression by rhEPO was only presented in the A549 cell line and required higher rhEPO concentrations(Hypoxia+rhEPO 8 U/ml vs.Hypoxia&Hypoxia+rhEPO 2 U/ml,p<0.05).Conclusion:The effect of prolonged high concentrations of rhEPO under hypoxic conditions resulted in accelerated cells proliferation of non-small-cell lung cancer and was independent of EPOR expression levels on the cell lines surface.Hypoxia resulted in increased expression of VEGF,HIF-1α,and PD-L1 on the NSCLC cell lines.Under normoxic conditions,rhEPO did not affect the expression of VEGF,HIF-1α,and PD-L1;but under hypoxic conditions,the application of rhEPO reduced the expression of VEGF,HIF-1α,and PD-L1,producing an impact on the biological behavior of tumor cells. | Yajing Zhang Yangchun Feng Xiaojie Sun | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 2 |
| 17 | Proposed methodology for online frequency response analysis based on magnetic coupling to detect winding deformations in transformers显示文摘Frequency response analysis is widely used as a method for the offline diagnosis of winding deformations in power transformers.To apply it to a working transformer,people need to determine how to inject the excitation signal and measure the response signal for windings that bear a rated voltage and current.In this study,a method to obtain the frequency response curve online is proposed.It uses the principle of magnetic field coupling to inject a frequency sweep signal into the windings through a Rogowski coil.Another Rogowski coil sensor placed at the root of a high-voltage bushing is used to measure the response current signal.Experiments on a 72.5 kV bushing show that metal accessories of the bushing have no influence on the injection or the measurement.The feasibility of this method was verified by experiments on charged 110/35/10 kV transformers at a factory and a working 35 kV transformer in a power station.The results show that it is safe to install the Rogowski coil at the root of the high-voltage bushing.The excitation signal can be injected into live windings and the response signal is measurable.Strong electromagnetic power frequency noise can be reduced and the frequency response curve can be measured online. | Yangchun Cheng Jiangang Bi Wenzhi Chang Yuan Xu Xiaohua Pan Xianwei Ma Shuai Chang | 2020 | High Voltage2020，5，3： | 2 |
| 18 | Planation Surfaces on the Tibet Plateau,China显示文摘A planation hypothesis is proposed to explain landform evolution of the Tibet Plateau.A denudation threshold(T),the maximum potential denudation rate for a certain type of rock,is introduced to explain the combined effects of lithology and tectonics on landform evolution.If the tectonic uplifting rate(U)is equal to or less than the threshold rate(U≤T),the tectonic uplifting and terrain denudation are in dynamic equilibrium,and landforms are in a steady state.The end product should be planation surfaces whether the original landforms are flat plains or deeply dissected mountains.If U>T,uplift and denudation are not able to reach a dynamic equilibrium state.The plateau surface is mostly underlain by soft rocks,such as the Mesozoic epimetamorphic argillites and Tertiary sedimentary rocks,while the mountain ranges comprise hard rocks,such as granite,gneiss and limestone.In soft rock regions,hills are low with a relative relief of mostly less than 100m and the slopes are gentle at a gradient of <20o.In contrast,hills can maintain steep slopes in hard rock regions.The Tibet Plateau has been under an equilibrium condition between tectonic uplifting and denudation except for the mountain ranges.The plateau might have reached the present altitudes before the Quaternary. | ZHANG Xinbao HE Xiubin WANG Yangchun LONG Yi | 2008 | Journal of Mountain Science2008，5，4： | 2 |
| 19 | 1,25-Dihydroxyvitamin D_3 modulates calcium transport in goat mammary epithelial cells in a dose- and energydependent manner显示文摘Background: Calcium is a vital mineral and an indispensable component of milk for ruminants. The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3(1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor(VDR), calcium binding protein D9k(calbindin-D9k), plasma membrane Ca2+-ATPase 1b(PMCA1b), PMAC2 b and Orai1, are involved in this process.However, it is still unclear whether 1,25-(OH)2D3could stimulate calcium transport in the ruminant mammary gland.The present trials were conducted to study the effect of 1,25-(OH)2D3supplementation and energy availability on the expression of genes and proteins related to calcium secretion in goat mammary epithelial cells.Methods: An in vitro culture method for goat secreting mammary epithelial cells was successfully established. The cells were treated with different doses of 1,25-(OH)2D3(0, 0.1, 1.0, 10.0 and 100.0 nmol/L) for calcium transport research, followed by a 3-bromopyruvate(3-Br PA, an inhibitor of glucose metabolism) treatment to determine its dependence on glucose availability. Cell proliferation ratios, glucose consumption and enzyme activities were measured with commercial kits, and real-time quantitative polymerase chain reaction(RT-q PCR), and western blots were used to determine the expression of genes and proteins associated with mammary calcium transport in dairy goats, respectively.Results: 1,25-(OH)2D3promoted cell proliferation and the expression of genes involved in calcium transport in a dose-dependent manner when the concentration did not exceed 10.0 nmol/L. In addition, 100.0 nmol/L 1,25-(OH)2D3inhibited cell proliferation and the expression of associated genes compared with the 10.0 nmol/L treatment.The inhibition of hexokinase 2(HK2), a rate-limiting enzyme in glucose metabolism, decreased the expression of PMCA1 b and PMCA2 b at the m RNA and protein levels as well as the transcription of Orai1, indicating that glucose availability was required for goat mammary calcium transport. The optimal concentration of 1,25-(OH)2D3that facilitated calcium transport in this study was 10.0 nmol/L.Conclusions: Supplementation with 1,25-(OH)2D3influenced cell proliferation and regulated the expression of calcium transport modulators in a dose- and energy-dependent manner, thereby highlighting the role of 1,25-(OH)2D3as an efficacious regulatory agent that produces calcium-enriched milk in ruminants when a suitable energy status was guaranteed. | Feifei Sun Yangchun Cao Chao Yu Xiaoshi Wei Junhu Yao | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 2 |
| 20 | Voice conversion using structured Gaussian mixture model in cepstrum eigenspace显示文摘A new methodology of voice conversion in cepstrum eigenspace based on structured Gaussian mixture model is proposed for non-parallel corpora without joint training.For each speaker,the cepstrum features of speech are extracted,and mapped to the eigenspace which is formed by eigenvectors of its scatter matrix,thereby the Structured Gaussian Mixture Model in the EigenSpace(SGMM-ES)is trained.The source and target speaker's SGMM-ES are matched based on Acoustic Universal Structure(AUS)principle to achieve spectrum transform function.Experimental results show the speaker identification rate of conversion speech achieves95.25%,and the value of average cepstrum distortion is 1.25 which is 0.8%and 7.3%higher than the performance of SGMM method respectively.ABX and MOS evaluations indicate the conversion performance is quite close to the traditional method under the parallel corpora condition.The results show the eigenspace based structured Gaussian mixture model for voice conversion under the non-parallel corpora is effective. | LI Yangchun YU Yibiao | 2015 | Chinese Journal of Acoustics2015，34，3： | 2 |
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