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| 1 | Characteristics of dissolved organic matter in lakes with different eutrophic levels in southeastern Hubei Province,China显示文摘Dissolved organic matter(DOM)plays a crucial role in both the carbon cycle and geochemical cycles of other nutrient elements,which is of importance to the management and protection of the aquatic environments.To achieve a more comprehensive understanding the characteristics of DOM in the Changjiang(Yangtze)River basin,water samples from four natural lakes(Xiandao,Baoan,Daye,and Qingshan)in southeastern Hubei Province in China with different eutrophication levels were collected and analyzed.The optical characteristics were analyzed using ultraviolet-visible spectrophotometry and excitation-emission matrix spectroscopy coupled with parallel factor analysis.The results show that:(1)two humic-like components(C1 and C2)and two protein-like substances(C3 and C4)of DOM were identified in all waterbodies;(2)C3 originated primarily from the degradation of microalgae and contributed substantially to humic-like components during transformation.C4 was widely present in the Changjiang River basin and its formation was related to microbial activity,rather than algal blooms or seasons.Influenced by the water mixing,the protein-like components were more likely to be transformed by microorganism,whereas humic-like components were more easily to be photobleached;(3)the concentration of DOM and the fluorescence intensity of humic-like components gradually increased with rising lake eutrophication levels.With respect to protein-like components,only C3 showed changes along the eutrophication gradients;(4)DOM showed a high affinity with permanganate index(COD Mn)and chlorophyll a(chl a)while the relationship was variable with phosphorus.This study helps us systematically understand the DOM characteristics,microbial activities,and pollutant transformation in the Changjiang River basin and provides reference to the ecological restoration of aquatic environments. | Weixiang REN Xiaodong WU Xuguang GE Guiying LIN Mengdie ZHOU Zijie LONG Xinhui YU Wei TIAN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 8 |
| 2 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 3 | NLP1 reciprocally regulates nitrate inhibition of nodulation through SUNN-CRA2 signaling in Medicago truncatula显示文摘Most legume plants can associate with diazotrophic soil bacteria called rhizobia,resulting in new root organs called nodules that enable N2 fixation.Nodulation is an energy-consuming process,and nodule number is tightly regulated by independent systemic signaling pathways controlled by CLE/SUNN and CEP/CRA2.Moreover,nitrate inhibits legume nodulation via local and systemic regulatory pathways.In Medicago truncatula,NLP1 plays important roles in nitrate-induced inhibition of nodulation,but the relationship between systemic and local pathways in mediating nodulation inhibition by nitrate is poorly understood.In this study,we found that nitrate induces CLE35 expression in an NLP1-dependent manner and that NLP1 binds directly to the CLE35 promoter to activate its expression.Grafting experiments revealed that the systemic control of nodule number involves negative regulation by SUNN and positive regulation by CRA2 in the shoot,and that NLP1’s control of the inhibition of rhizobial infection,nodule development,and nitrogenase activity in response to nitrate is determined by the root.Unexpectedly,grafting experiments showed that loss of CRA2 in the root increases nodule number at inhibitory nitrate levels,probably because of CEP1/2 upregulation in the cra2 mutants,suggesting that CRA2 exerts active negative feedback regulation in the root. | Zhenpeng Luo Jie-shun Lin Yali Zhu Mengdi Fu Xiaolin Li Fang Xie | 2021 | Plant Communications2021，2，3： | 5 |
| 4 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 5 | Chemogenetic Therapeutics: A Powerful Tool to Control Cortical Seizures in Non-human Primates显示文摘The Basis for Investigating the Role of DREADDs in Epilepsy in Non-human Primates Epilepsy is one of the common neurological disorders,characterized by spontaneous and recurrent seizures.Its etiology and pathophysiology are complicated,where the imbalance of excitatory glutamate and inhibitory GABAergic neurotransmission is well documented[1].Frontal lobe epilepsy(FLE)is the second most common focal epilepsy. | Lin Yang Mengdi Zhang Yi Wang Zhong Chen | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 6 | Seco-cyclic phorbol derivatives and their anti-HIV-1 activities显示文摘Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of phorbol.Concurrently,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand complex.The influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further exploration.This research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol derivatives.The anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration calorimetry.The findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding affinity.Remarkably,compound S11,with an EC50 of 0.27μmol·L^(−1) and a CC50 of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δprotein.These results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity. | HUANG Xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng WANG Haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 7 | Geochronology,Geochemistry,and Implications of Aplite Dyke in the Giant Jiama Porphyry Copper System,Tibet显示文摘Jiama is a giant,high-grade porphyry copper system in the Gangdese metallogenic belt,Tibet.Multistage intermediate-felsic porphyries intruded in this deposit,some of which are strongly associated with copper-polymetallic mineralization.These ore-bearing porphyries include monzogranite,granodiorite,and quartz diorite porphyries.A new granite aplite dyke was found in the south of Jiama.Its age,genesis,and relationship with ore-related magmatism are obscure.Here,its emplacement age and petrogenesis were determined using mineralogy,zircon U-Pb dating,geochemistry,and Sr-Nd-Pb isotope studies.The zircon LA-ICP-MS U-Pb age of the aplite dyke is 16.66±0.21 Ma(n=14,MSWD=0.66),earlier than that of the ore-bearing porphyries(~15 Ma)in Jiama.Furthermore,the aplite exhibits high amounts of silicon(SiO_(2)=73.39%-74.74%),potassium(K_(2)O=5.12%-6.61%),aluminum(Al_(2)O_(3)=14.25%-14.69%),and light/heavy rare earth elements(LREE/HREE=12.12-16.19)as well as negative europium(δEu=0.47-0.72)and weak negative cerium anomalies(δCe=0.84-0.93).The aplite dyke is characteristic of metaluminous-peraluminous I-type granite,which is rich in large-ion lithophile elements(Rb,Ba,Th and U)and depleted in high-field-strength elements(Nb,P and Ti).The aplite dyke and ore-bearing porphyries in the Jiama deposit are the results of a partial melting of the juvenile lower crust,according to whole-rock geochemistry and Sr-Nd-Pb isotope data,but the dyke and ore-bearing porphyries were emplaced from the same magma chamber at different times.Thus,the aplite dyke shows the composition of the early evolution stage of shallow magma in the Jiama deposit and is the product of rapid condensation and crystallization. | QI Jing TANG Juxing LIN Bin YANG Hairui TANG Xiaoqian TANG Pan FANG Xiang ZHANG Tingting LI Faqiao SUN Miao WANG Mengdie CUI Hao XIE Jinling | 2023 | Acta Geologica Sinica(English Edition)2023，97，5： | 0 |
| 8 | LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins显示文摘Long noncoding RNAs(lncRNAs)have been widely proven to be involved in liver lipid homeostasis.Herein,we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in HepG2 cells.Knockdown of lncRP11-675F6.3 leads to a significant reduction in apolipoprotein 100(ApoB100),microsomal triglyceride transfer protein(MTTP),ApoE and ApoC3 with increased cellular triglyceride level and autophagy.Furthermore,we find that ApoB100 is obviously colocalized with GFP-LC3 in autophagosomes when lncRP11-675F6.3 is knocked down,indicating that elevated triglyceride accumulation likely related to autophagy induces the degradation of ApoB100 and impairs very low-density lipoprotein(VLDL)assembly.We then identify and validate that hexokinase 1(HK1)acts as the binding protein of lncRP11-675F6.3 and mediates triglyceride regulation and cell autophagy.More importantly,we find that lncRP11-675F6.3 and HK1 attenuate high fat diet induced nonalcoholic fatty liver disease(NAFLD)by regulating VLDL-related proteins and autophagy.In conclusion,this study reveals that lncRP11-675F6.3 is potentially involved in the downstream of mTOR signaling pathway and the regulatory network of hepatic triglyceride metabolism in cooperation with its interacting protein HK1,which may provide a new target for fatty liver disorder treatment. | Lingling Wang Xiaojuan Fang Ziyou Yang Xueling Li Mengdi Cheng Liang Cheng Ganglin Wang Wei Li Lin Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 9 | Integrated Women Framework,Meaning of Work,Personal Resilience,Hybrid Work,Well-Being,and Job Satisfaction:A Preliminary Study of Professional Women’s Work Experience in China显示文摘The purpose of the study is to propose a conceptual framework consisting of paths that contribute to job satisfaction of professional women in China.The preliminary study,which adopts the Integrated Women Fra mework,is intended to guide organizations and women professionals at work in China.The objectives of the study are:(1)to explore the nature and extent of relationships such as meaning of work,hybrid work environment,workplace policies,personal resilience,and job satisfaction;(2)to explore the application of the Integrated Women F ramework,as a mediator,in understanding and explaining the construct of job satisfaction and associated variables.More precisely,the present study aims(1)to explore the paths that lead to job satisfaction among working women,and(2)to understand job satisfaction to provide insight into how an organization can support and empower working women to achieve it.The framework“integrated women”(modified from an ideal type of construction coined by Lin and Moore in 1983)represents women with resilience to adversities and challenges,who have the ability to make informed choices between personal and professional aspects,to exercise their meaning/purpose at work,and manage flexibility in their work environment(e.g.,hybrid work).The study is both exploratory and explanatory.It uses the survey method for data collection.Women’s greater participation in the workforce has been an important step towards increasing workplace inclusion and gender equality.The study can be duplicated in other Asian regions and in the West since working women throughout the world share similar experiences.This study adopts a comprehensive approach to understanding and explaining the variables by combining both individual and contextual factors and their interactions.Based on this fram ework,the researchers made sure that all the variables are studied holistically so that the outcomes of this study will make substantial contributions to understanding of both theory(e.g.,resilience and job satisfaction)and workplace practices(e.g.,flexibility in the work environment).This paper focuses on the quantitative data derived from the China study of 152 subjects.Integrated Women Framew ork was used as a mediating variable in this study.In addition to descriptive data and correlation outcomes,the major findings from path analysis indicate that the mediating effects of integrated women were similar for the two outcomes of endogenous dependent variables:job satisfaction and well-being.For both,integrated women significantly mediated the relations between hybrid work and the outcomes,as well as the relations between personal resilience and the outcomes.In a nutshell,the preliminary analysis of the China data found that job satisfaction outcome is primarily affected by working women’s resilience in their work experience,a favorable work environment(work policies and hybrid work)and by their well-being(especially economic/financial well-being).In other words,job satisfaction is related to both personal and organizational factors. | Hongmei Han Phylis Lan Lin Mengdi Liu Hui Zhang Keith Miller Liang Liu May Darli Phone Swe Kamaljit Grewall Maitra Vijayakumar Parameswaran Unnithan | 2023 | US-China Education Review(B)2023，13，3： | 0 |
| 10 | Proton-anion Ion-pair Recognition by a Hexaazatri- phenylene-Hexaurea Receptor显示文摘hexaazatriphenylene (帽子)的识别行为向在 THF 答案的不同的酸的衍生物通过 1 H NMR ,紫外力并且荧光分光镜的实验和半实验的计算,它表明这像推进器的帽子受体能由夹质子和卤素(氯化物或溴化物)共同装配进分层的建筑群阴离子 synergistically 在受体分子之间。而且,对肉眼可见的可逆、显著的颜色变化能被观察,当卤素酸和底或者被介绍时。 | Tianguang Zhan Mengdi Lin Lin Wu Xiang Zhang Liang Zhang Xin Zhao Kangda Zhang | 2017 | Chinese Journal of Chemistry2017，35，4： | 0 |
| 11 | UHRF1/DNMT1—MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer显示文摘As confusion mounts over RNA isoforms involved in phenotypic plasticity,aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity(ITH).Protease serine 3(PRSS3),possessing four splice variants(PRSS3-SVs;PRSS3-V1—V4),is an indispensable trypsin that shows paradoxical effects on cancer development.Here,we found that PRSS3 transcripts and their isoforms were divergently expressed in lung cancer,exhibiting opposing functions and clinical outcomes,namely,oncogenic PRSS3-V1 and PRSS3-V2 versus tumorsuppressive PRSS3-V3,by targeting different downstream genes.We identified an intragenic CpG island(iCpGI)in PRSS3.Hypermethylation of iCpGI was mediated by UHRF1/DNMT1 complex interference with the binding of myeloid zinc finger 1(MZF1)to regulate PRSS3 transcription.The garlic-derived compound diallyl trisulfide cooperated with 5-aza-2'-deoxycytidine to exert antitumor effects in lung adenocarcinoma cells through site-specific iCpGI demethylation specifically allowing MZF1 to upregulate PRSS3-V3 expression.Epigenetic silencing of PRSS3-V3 via i CpGI methylation(iCpGIm)in BALF and tumor tissues was associated with early clinical progression in patients with lung cancer but not in those with squamous cell carcinoma or inflammatory disease.Thus,UHRF1/DNMT1—MZF1 axismodulated site-specific iCpGIm regulates divergent expression of PRSS3-SVs,conferring nongenetic functional ITH,with implications for early detection of lung cancer and targeted therapies. | Shuye Lin Hanli Xu Lin Qin Mengdi Pang Ziyu Wang Meng Gu Lishu Zhang Cong Zhao Xuefeng Hao Zhiyun Zhang Weimin Ding Jianke Ren Jiaqiang Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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