|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Comparison of different cooling methods for extending shelf life of postharvest broccoli显示文摘This study aimed to investigate and compare the effects of vacuum cooling,cooling water and cold room methods on the shelf life of broccoli.The experiments were divided into four groups:vacuum cooling(A),ice-water cooling(B),cold room cooling(C)and control.The cooling rate and changes of weight loss,respiratory rate,chlorophyll,vitamin C,reducing sugar content and sensory properties were measured at intervals of five days.The results indicated that vacuum cooling was the most effective method for extending the shelf life of postharvest broccoli in terms of cooling rate,respiration rate,chlorophyll,vitamin C,reducing sugar and sensory properties.Moreover,spraying the broccoli with water during the vacuum cooling process resulted in a significant reduction in weight compared with the other two cooling methods and did not reduce the quality of the broccoli.Consequently,vacuum cooling treatment can be applied to broccoli after harvest in the field to maintain quality during transportation and storage.Additionally,the application of water spraying during vacuum cooling can considerably reduce the negative influence caused by vacuum cooling. | Ding Tian Liu Fen Ling Jiangang Kang Mengli Yu Jingfen Ye Xingqian Liu DongHong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 5 |
| 3 | Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline, thermal hydrolysis and ultrasonic pretreatments显示文摘Sewage sludge in the wastewater treatment plants contains considerable amount of antibiotic resistance genes (ARGs). A few studies have reported that anaerobic digestion (AD) could successfully remove some ARGs from sewage sludge, but information on the fate of ARGs in sludge pretreatment-AD process is still very limited. In this study, three sludge pretreatment methods, including alkaline, thermal hydrolysis and ultrasonic pretreatments, were compared to investigate the distribution and removal of ARGs in the sludge pretreatment-AD process. Results showed that the ARGs removal efficiency of AD itself was approximately 50.77%, and if these three sludge pretreatments were applied, the total ARGs removal efficiency of the whole pretreatment-AD process could be improved up to 52.50%-75.07%. The ultrasonic pretreatment was more efficient than alkaline and thermal hydrolysis pretreatments. Although thermal hydrolysis reduced ARGs obviously, the total ARGs rebounded considerably after inoculation and were only removed slightly in the subsequent AD process. Furthermore, it was found that the total ARGs concentration significantly correlated with the amount of 16S rRNA gene during the pretreatment and AD processes, and the bacteria carrying ARGs could be mainly affiliated with Proteobacteria. | Mengli Wang Ruying Li Qing Zhao | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 5 |
| 4 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | Promotion of Mn Doped Co/CNTs Catalysts for CO Hydrogenation to Light Olefins显示文摘与各种各样的内容, Mn 被介绍进支持的碳 nanotubes ( CNT )钴催化剂和获得的 Mn-Co/CNTs 催化剂被调查让公司加氢点亮链烯并且由 N2 吸附描绘了,X光检查衍射( XRD ),X光检查光电子系列( XPS ), H2 温度规划了减小( TPR ),公司温度规划了解吸附作用( TPD )和传播电子显微镜( TEM )。结果显示到支持 CNTs 的公司催化剂的 Mn (0.3 wt%) 的小数量的增加显著地增加了 C2C4 石蜡的选择并且减少 CH4 的选择。与到钴催化剂的 Mn 的进一步的增加,然而, CH4 选择与 C5+ 选择的增加一起显然减少了。与 unpromoted 催化剂相比,支持 Mn 的钴催化剂增加了 C2C4/C20C40 臼齿的比率。 | Liping Tang Chengli Song Xiaolong Yang Mengli Li Bin Hu | 2013 | Chinese Journal of Chemistry2013，31，6： | 4 |
| 6 | Metal-organic framework-derived CoSn/NC nanocubes as absorbers for electromagnetic wave attenuation显示文摘Metal-organic framework-derived composites have been widely used in electromagnetic wave(EMW)absorption,but the traditional synthetic strategy greatly limits the structure and species of MOFs.This research provided a solvent-free method to synthesize Co-MOF and its derivatives.Using CoSnO_(3)as the precursor,the preparation of Co-MOF is achieved by bridging the cobalt(II)ion of CoSnO_(3)and the 2-methylimidazole skeleton.The CoSn/N-doped carbon(CoSn/NC)composites derived from CoSnO_(3)-MOF(Co-MOF with CoSnO_(3)as Co source)retain the original morphology of CoSnO_(3).Besides,the polarization effect produced by the N-doped carbon layers also benefits the excellent EMW absorption performance of the CoSn/NC composites.It is reflected in the minimum reflection loss(RL)of-48.2 dB at 2.2 mm and the effective bandwidth(EBA)of 5.84 GHz.This work provides a new channel to the construction of Co-MOFs,which could be extended to other Co-based oxides and vastly expand the species of MOFs based on metallic Co. | Chenxi Wang Zirui Jia Shuangqiao He Jixi Zhou Shuo Zhang Mengli Tian Bingbing Wang Guanglei Wu | 2022 | Journal of Materials Science & Technology2022，，13： | 4 |
| 7 | Optical properties and applications for MoS_2-Sb_2Te_3-MoS_2 heterostructure materials显示文摘Two-dimensional(2D) materials with potential applications in photonic and optoelectronic devices have attracted increasing attention due to their unique structures and captivating properties. However, generation of stable high-energy ultrashort pulses requires further boosting of these materials' optical properties, such as higher damage threshold and larger modulation depth. Here we investigate a new type of heterostructure material with uniformity by employing the magnetron sputtering technique. Heterostructure materials are synthesized with van der Waals heterostructures consisting of MoS_2 and Sb_2Te_3. The bandgap, carrier mobility, and carrier concentration of the MoS_2-Sb_2Te_3-MoS_2 heterostructure materials are calculated theoretically. By using these materials as saturable absorbers(SAs), applications in fiber lasers with Q-switching and mode-locking states are demonstrated experimentally. The modulation depth and damage threshold of SAs are measured to be 64.17%and 14.13 J∕cm^2, respectively. Both theoretical and experimental results indicate that MoS_2-Sb_2Te_3-MoS_2 heterostructure materials have large modulation depth, and can resist high power during the generation of ultrashort pulses. The MoS_2-Sb_2Te_3-MoS_2 heterostructure materials have the advantages of low cost, high reliability, and suitability for mass production, and provide a promising solution for the development of 2D-material-based devices with desirable electronic and optoelectronic properties. | WENJUN LIU YA-NAN ZHU MENGLI LIU BO WEN SHAOBO FANG HAO TENG MING LEI LI-MIN LIU ZHIYI WEI | 2018 | Photonics Research2018，6，3： | 3 |
| 8 | Study of K/Mn-MgO Supported Fe Catalysts with Fe(CO)5 and Fe(NO3)3 as Precursors for CO Hydrogenation to Light Alkenes显示文摘二 K/Mn-MgO 支持了催化剂被 Fe (公司) 准备 5 并且 Fe (NO3 ) 3 是先锋分别地。获得的 Fe-K/Mn-MgO 催化剂被测试让公司加氢点亮链烯并且由 X 光检查描绘了粉末衍射(XRD ) , X 光检查光电子系列(XPS ) , H2 规划温度的减小(H2-TPR ) , H2,公司和 CO2 规划温度的解吸附作用(H2, CO/CO2-TPD ) 并且传播电子显微镜(TEM ) 。结果显示有装载的 10 wt% Fe 的催化剂由 Fe (公司) 准备了 5 当先锋显示了在 syngas 的更好的性能比从 Fe (NO3 ) 获得的点亮链烯 3 作为先锋,在 CO 变换是 62.50% ,选择在 350 摀畲獧是 55.95% 的地方吗? | Liping Tang Chengli Song Mengli Li Xiaolong Yang Bin Hu | 2013 | Chinese Journal of Chemistry2013，31，10： | 3 |
| 9 | In vitro comparison of the hemocompatibility of diamond-like carbon and carbon nitride coatings with different atomic percentages of N显示文摘Carbon nitride (CNx) and diamond-like carbon (DLC) coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of nitrogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.12, the CN0.22 coating showed longer dynamic clotting time (about 42 min), static clotting time (23.6 min) and recalcification time (45.6 s), as well as lower platelet adhesion (102 cells μm 2), aggregation, and activation. The presence of nitrogen in the CNx coatings induced their enhanced hemocompatibility compared with DLC. | ZHAO MengLi LI DeJun ZHANG YiTeng GUO MeiXian DENG XiangYun GU HanQing WAN RongXin | 2012 | Science China(Life Sciences)2012，55，4： | 3 |
| 10 | Ubiquitin-mediated NFκB degradation pathway显示文摘原子因素 κ B (NFκ B ) 抄写因素在发炎和免疫起关键作用。NFκ 的 dysregulation; B 与煽动性、自体免疫的疾病和癌症被联系。NFκ B 激活被 ubiquitin 依赖的 proteasomal 降级小径否定地调整。在现在的评论,我们在我们理解讨论最近的进展 ubiquitin ligases 调整 NFκ B 降级小径。 | Huimin Xu Mengli You Haifeng Shi Yongzhong Hou | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 11 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 12 | Structural Study on Four co-Crystals of N-Containing Heteroaromatics with Iodofluorobenzene显示文摘 | JI Baoming DENG Dongsheng WANG Weizhou WANG Ke HE Mengli | 2015 | Chemical Research in Chinese Universities2015，31，1： | 2 |
| 13 | Global nitrogen input on wetland ecosystem:The driving mechanism of soil labile carbon and nitrogen on greenhouse gas emissions显示文摘Greenhouse gas emissions from wetlands are significantly promoted by global nitrogen input for changing the rate of soil carbon and nitrogen cycling,and are substantially affected by soil labile carbon and nitrogen conversely.However,the driving mechanism by which soil labile carbon and nitrogen affect greenhouse gas emissions from wetland ecosystems under global nitrogen input is not well understood.Working out the driving factor of nitrogen input on greenhouse gas emissions from wetlands is critical to reducing global warming from nitrogen input.Thus,we synthesized 72 published studies(2144 paired observations)of greenhouse gas fluxes and soil labile compounds of carbon and nitrogen(ammonium,nitrate,dissolved organic carbon,soil microbial biomass nitrogen and carbon),to understand the effects of labile carbon and nitrogen on greenhouse gas emissions under global nitrogen input.Across the data set,nitrogen input significantly promoted carbon dioxide,methane and nitrous oxide emissions from wetlands.In particular,at lower nitrogen rates(<100 kg ha^(-1)$·yr^(-1))and with added ammonium compounds,freshwater wetland significantly promoted carbon dioxide and methane emissions.Peatland was the largest nitrous oxide source under these conditions.This meta-analysis also revealed that nitrogen input stimulated dissolved organic carbon,ammonium,nitrate,microbial biomass carbon and microbial biomass nitrogen accumulation in the wetland ecosystem.The variation-partitioning analysis and structural equation model were used to analyze the relationship between the greenhouse gas and labile carbon and nitrogen further.These results revealed that dissolved organic carbon(DOC)is the primary factor driving greenhouse gas emission from wetlands under global nitrogen input,whereas microbial biomass carbon(MBC)more directly affects greenhouse gas emission than other labile carbon and nitrogen. | Mengli Chen Lian Chang Junmao Zhang Fucheng Guo Jan Vymazal Qiang He Yi Chen | 2020 | Environmental Science and Ecotechnology2020，，4： | 2 |
| 14 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 15 | Linezolid versus vancomycinfor the treatment of gram positive bacterial infections: meta- analysis of randomized controlled trials 显示文摘 | Beibei L Yun C Mengli C | 2010 | Int J Antimicrob Agents2010，35，1： | 1 |
| 16 | Robust temperature control for microwave heating of ceramics显示文摘 | Beale Guy O LI Mengli | 1997 | IEEE Transactions on IndustrialElectronics1997，44，1： | 1 |
| 17 | A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat. | Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang | 2023 | Molecular Plant2023，16，2： | 1 |
| 18 | Oscillations of electron flux in photode- tachment of H- in an electric field 显示文摘 | Du Mengli | 1989 | PhysicalReview A1989，40，9： | 1 |
| 19 | Phase II multicenter, randomized, double‐blind study of recombinant mutated human tumor necrosis factor‐α in combination with chemotherapies in cancer patients显示文摘 | MengLi TianjiaoXu ZhaoZhang XiaochangXue CunZhang XinQin WeinaLi QiangHao | 2012 | Cancer Science2012，，2： | 1 |
| 20 | Localization in Supermarket Based on RFID Technology显示文摘 | Song Wei LI Mengli | 2012 | Procedia Engineering2012，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员