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| 1 | Linezolid versus vancomycinfor the treatment of gram positive bacterial infections: meta- analysis of randomized controlled trials 显示文摘 | Beibei L Yun C Mengli C | 2010 | Int J Antimicrob Agents2010，35，1： | 1 |
| 2 | Genetic polymorphisms of GSTP1 related to response to 5-FU-oxaliplatin-based chemotherapy and clinical outcome in advanced colorectal cancer patients显示文摘 | Jun L Haiping Z Beibei Y | 2009 | Swiss Med Wkly2009，139，4950： | 1 |
| 3 | Genetic polymorphisms of GSTP1 related to response to 5-FU-oxaliplatin-based chemotherapy and clinical outcome in advanced eolorectal cancer patients 显示文摘 | Jun L Haiping Z Beibei Y | 2009 | Swiss Med Wldy2009，139，4950： | 1 |
| 4 | Linezolid versus vancomycin for the treatment of gram-positive bacterial infections: Meta-analysis of randomised controlled trials显示文摘 | Beibei L Yun C Mengli C | 2010 | IntJAntimicrobAgents2010，5，1： | 1 |
| 5 | The application of soma- tosensory evoked potentials in spinal cord injury rehabilitation 显示文摘 | Caizhong X Chunlei S Beibei L | 2014 | NeuroRehabilitation2014，35，4： | 1 |
| 6 | Advances in Cognitive Radio Networks: A Survey 显示文摘 | Beibei W K J Ray L | 2011 | IEEE Journal of Selected Topics In signal Processing (S1932-4553)2011，5，1： | 1 |
| 7 | Linezolid versus vancomycin for the treatment of gram- positive bacterial infections: meta-analysis of randomised controlled trials显示文摘 | BEIBEI L YUN C MENGLI C | 2010 | Int J Antimicrob Agents2010，35，1： | 1 |
| 8 | Sanguinarine suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma via inhibiting mTOR signaling显示文摘OBJECTIVE: To confirm the anti-NPC effect of sanguinarine(SA) through a series of wet experiments.METHODS: NPC cell viability was determined by proliferation experiment. Cell clone formation experiment, cell scratch test, transwell migration and invasion experiment and flow cytometry-based cell apoptosis assay were further performed. In addition, Western blotting was performed to investigate the cell signaling pathway. All the relevant experimental data were statistically processed using SPSS 16.0 software.RESULTS: The results showed that sanguinarine represented a time and dose dependent inhibition effects on NPC cell proliferation including the low differentiated CNE2 cells and high metastatic 5-8F cells, along with the cell cloning ability reduction. In addition, sanguinarine has a certain inhibitory effect on the invasion and migration of NPC cells. Mechanistically, sanguinarine displayed the anti-NPC effects mainly involved into the suppression of m TOR signaling and cell apoptosis, which is closely associated with the tumor growth and metastatic malignancy. CONCLUSIONS: Collectively, we discover that sanguinarine is a new high-efficiency anti-NPC monomer of Chinese medicine, with a value for the follow-up preclinical research. | YANG Mengzhe ZHANG Beibei LIANG Zhenqiang CHENG Nannan LüAnqiao YANG Jianyu GUO Xingzhe BAI Xianyu HUANG Yuanjiao JIAO Aijun XU Ning | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 9 | Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair显示文摘DNA double-strand breaks are repaired through either non-homologous end joining(NHEJ) or homologous recombination repair(HRR) pathway.The well-characterized regulatory mechanisms of double-strand break repair(DSBR) are mainly found at the level of complicated repair protein interactions and modifications.Regulation of DSBR at the transcriptional level was also reported.In this study,we found that DSBR can be regulated by miR-34a at the post-transcriptional level.Specifically,miR-34a,which can be activated by DNA damages,represses DSBR activities by impairing both NHEJ and HRR pathways in cultured cells.The repression is mainly through targeting the critical DSBR promoting factor SIRT1,as ectopically expressed SIRT1 without 3'-UTR can rescue the inhibitory roles of miR-34a on DSBR.Further studies demonstrate that SIRT1 conversely represses miR-34a expression.Taken together,our data show that miR-34a is a new repressor of DSBR and the mutual inhibition between miR-34a and SIRT1 may contribute to regulation of DNA damage repair. | XU Miao LU Lu MAO BeiBei Lü Xiang WU XueSong LI Lei LIU DePei | 2013 | Chinese Science Bulletin2013，58，9： | 0 |
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