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| 1 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 2 | In vitro Anthocyanin Induction and Metabolite Analysis in Malus spectabilis Leaves Under Low Nitrogen Conditions显示文摘Anthocyanins are the most widely produced secondary metabolites in plants,and they play an important role in plant growth and reproduction.The nitrogen source is an important factor affecting anthocyanin production,but the nitrogen concentrations on metabolism and the underlying genetic basis remain unclear.In this study,in vitro anthocyanin induction was conducted on Malus spectabilis.The leaf explants were cultivated in media containing different nitrogen concentrations.The results suggested that when the nitrogen contents decreased in limit,the color of leaf explants turned from green to red,and increased anthocyanin accumulation led to a change in phenotype.Furthermore,the content of other flavonoids,such as dihydroquercetin,epicatechin,and catechin,increased under low nitrogen conditions.The transcription levels of the general flavonoid pathway genes,from phenylalanine ammonia lyase(PAL)to anthocyanidin synthase(ANS),were associated with the concentration of corresponding flavonoid compounds and phenotype changes.In particular,the expression level of ANS increased substantially under a low nitrogen treatment,which was significantly and positively correlated with the anthocyanin levels(R2=0.72,P<0.05).The increased expression patterns of anthocyanin pathway genes were similar to that of the transcription factor MYB10.We further verified MYB10 played an important role in the anthocyanin pathway in leaves of Malus spectabilis.These results suggested that we can improve the desirable ornamental plant phenotypes by controlling nitrogen content.This process may offer clues to further development of new agricultural practices. | Jiaxin Meng Yan Gao Meiling Han Pengyuan Liu Chen Yang Ting Shen Houhua Li | 2020 | Horticultural Plant Journal2020，6，5： | 13 |
| 3 | IncR26319/miR-2834/EndophilinA axis regulates oogenesis of the silkworm,Bombyx mori显示文摘Oocyte maturation is critical for insect reproduction.Vitellogenesis,the timely production and uptake of vitellogenin(Vg),is crucial for female fecundity.Vg is synthesized in fat body and absorbed by the oocytes through endocytosis during insect oogenesis.In the silkworm,Bombyx mori,we discovered that a nucleus-enriched long-noncoding RNA(lncRNA)lncR26319 regulates Endophilin A(EndoA)-a member of the endophilin family of endocytic proteins-through competitive binding to miR-2834.The lncR26319-miR-2834-EndoA axis was required for Vg endocytosis in the silkworm;loss of EndoA or overexpression ofmiR-2834significantlyreduced eggnumbers invirginmoths.Inaddition,accumulation of miR-2834 resulted in pupal and adult deformation and reduced fecundity in females.The expression of Vg,30-kDa(30K)protein,and egg-specific protein(Esp)decreased after knockdown of EndoA or overexpression of miR-2834,while knockdown of miR-2834 had an opposite effect on the expression of Vg,30K protein gene,and Esp.These results suggest that the lncR26319-miR-2834-EndoA axis contributes to the endocytic activity in theVguptake and leads to the normal progression of oogenesis in the silkworm.Thus,miR-2834 and EndoA are crucial for female reproduction and could be potential targets for new pest management strategies in lepidopterans. | Yi Wang Yu Fu Hao Chena Chenyue Zhao Qunxia Huang Meiling Chang Wujie Qiu Yawen Shen Dandan Li | 2023 | Insect Science2023，30，1： | 1 |
| 4 | Catalytic Combustion of Formaldehyde on Gold/Iron-Oxide Catalysts显示文摘 | Li Changyan Shen Yuenian Jia Meiling | 2008 | Catal Commun2008，9，3： | 1 |
| 5 | Behavior of a unit proton exchange membrane fuel cell in a stack under fuel starvation显示文摘 | Dong Liang Meiling Dou Ming Hou Qiang Shen Zhigang Shao Baolian Yi | 2011 | Journal of Power Sources2011，，13： | 1 |
| 6 | Behaviors of proton exchange membrane fuel cells under oxidant starvation显示文摘 | Meiling Dou Ming Hou Dong Liang Qiang Shen Huabing Zhang Wangting Lu Zhigang Shao Baolian Yi | 2010 | Journal of Power Sources2010，，5： | 1 |
| 7 | Tangeretin inhibits fungal ferroptosis to suppress rice blast显示文摘Flavonoids are polyphenolic secondary metabolites that function as signaling molecules,allopathic compounds,phytoalexins,detoxifying agents and antimicrobial defensive compounds in plants.Blast caused by the fungus Magnaporthe oryzae is a serious disease affecting rice cultivation.In this study,we revealed that a natural flavonoid,tangeretin,substantially delays the formation of M.oryzae appressoria and blocks the development of blast lesions on rice plants.Our data suggest that tangeretin has antioxidant activity that interferes with conidial cell death/ferroptosis,which is critical for M.oryzae pathogenicity.Tangeretin showed a ferroptosis inhibition efficacy comparable to the well-established liproxstatin-1.Furthermore,overexpression of the NADPH oxidases NOX1 or NOX2 significantly decreased sensitivity toward tangeretin treatment,suggesting Nox-mediated lipid peroxidation as a possible target for tangeretin in regulating redox signaling and ferroptosis in M.oryzae.Our nursery and field tests showed that application of tangeretin can effectively mitigate overall disease symptoms and prevent leaf blast.Our study reveals the plant-derived fungal ferroptosis inhibitor tangeretin as a potential and novel antifungal agrochemical for the sustainable prevention of the devastating blast disease in important cereal crops. | Meiling Liang Huijuan Ye Qing Shen Xianya Jiang Guobing Cui Wenxiang Gu Lian-Hui Zhang Naweed I.Naqvi Yi Zhen Deng | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 8 | Fabri- cation of CTP/HAp novel gradient composite bioceram- ies显示文摘 | Shen Meiling Zhao Zhongwei Wen Shimei | 2007 | Transaction Nonferrous Metals Social China2007，17，： | 1 |
| 9 | A highly efficient open-shell singlet luminescent diradical with strong magnetoluminescence properties显示文摘Developing open-shell singlet(OS)diradicals with high luminescent properties and exceptional single-molecule magnetoluminescence(ML)performance is extremely challenging.Herein,we propose a concept to enhance luminescent efficiency by adjusting the donor conjugation of OS diradicals,thereby achieving a highly luminescent diradical,DR1,with outstanding stability and making it a viable option for use in the emitting layer of organic light-emitting diodes(OLEDs).More importantly,the 0.5wt%-DR1 doped film demonstrates significant single-molecule magnetoluminescence(ML)properties.A giant ML value of 210%is achieved at a magnetic field of 7T,showing the great potential of DR1 in magneto-optoelectronic devices. | Alim Abdurahman Li Shen Jingmin Wang Meiling Niu Ping Li Qiming Peng Jianpu Wang Geyu Lu | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 10 | A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence显示文摘Neoadjuvant chemotherapy has become an indispensable weapon against high-risk resectable cancers,which benefits from tumor downstaging.However,the utility of chemotherapeutics alone as a neoadjuvant agent is incapable of generating durable therapeutic benefits to prevent postsurgical tumor metastasis and recurrence.Herein,a tactical nanomissile(TALE),equipped with a guidance system(PD-L1 monoclonal antibody),ammunition(mitoxantrone,Mit),and projectile bodies(tertiary amines modified azobenzene derivatives),is designed as a neoadjuvant chemo-immunotherapy setting,which aims at targeting tumor cells,and fast-releasing Mit owing to the intracellular azoreductase,thereby inducing immunogenic tumor cells death,and forming an in situ tumor vaccine containing damage-associated molecular patterns and multiple tumor antigen epitopes to mobilize the immune system.The formed in situ tumor vaccine can recruit and activate antigen-presenting cells,and ultimately increase the infiltration of CD8^(+)T cells while reversing the immunosuppression microenvironment.Moreover,this approach provokes a robust systemic immune response and immunological memory,as evidenced by preventing 83.3%of mice from postsurgical metastasis or recurrence in the B16-F10 tumor mouse model.Collectively,our results highlight the potential of TALE as a neoadjuvant chemo-immunotherapy paradigm that can not only debulk tumors but generate a long-term immunosurveillance to maximize the durable benefits of neoadjuvant chemotherapy. | Tao He Mingxing Hu Shunyao Zhu Meiling Shen Xiaorong Kou Xiuqi Liang Lu Li Xinchao Li Miaomiao Zhang Qinjie Wu Changyang Gong | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 11 | An engineered xCas12i with high activity,high specificity,and broad PAM range显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type II Cas9 and type V Cas12 systems,which serve in the adaptive immunity of prokaryotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with type II systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019). | Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Yingsi Zhou Hui Yang | 2023 | Protein & Cell2023，14，7： | 0 |
| 12 | Self-sufficient nanoparticles with dual-enzyme activity trigger radical storms and activate cascade-amplified antitumor immunologic responses显示文摘Radiotherapy(RT) can potentially induce systemic immune responses by initiating immunogenic cell death(ICD) of tumor cells.However,RT-induced antitumor immunologic responses are sporadic and insufficient against cancer metastases.Herein,we construct multifunctional self-sufficient nanoparticles(MARS) with dual-enzyme activity(GOx and peroxidase-like) to trigger radical storms and activate the cascade-amplified systemic immune responses to suppress both local tumors and metastatic relapse.In addition to limiting the Warburg effect to actualize starvation therapy,MARS catalyzes glucose to produce hydrogen peroxide(H_(2)O_(2)),which is then used in the Cu^(+)-mediated Fenton-like reaction and RT sensitization.RT and chemodynamic therapy produce reactive oxygen species in the form of radical storms,which have a robust ICD impact on mobilizing the immune system.Thus,when MARS is combined with RT,potent systemic antitumor immunity can be generated by activating antigen-presenting cells,promoting dendritic cells maturation,increasing the infiltration of cytotoxic T lymphocytes,and reprogramming the immuno suppre ssive tumor microenvironment.Furthermore,the synergistic therapy of RT and MARS effectively suppresses local tumor growth,increases mouse longevity,and results in a 90% reduction in lung metastasis and postoperative recurrence.Overall,we provide a viable approach to treating cancer by inducing radical storms and activating cascade-amplified systemic immunity. | Liping Bai Jin Yang Siting Yu Zhongzheng Xiang Yuanyuan Zeng Meiling Shen Xiaorong Kou Qinjie Wu Changyang Gong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 13 | Scanning cathodoluminescence microscopy: applications in semiconductor and metallic nanostructures显示文摘 | Zhixin Liu Meiling Jiang Yanglin Hu Feng Lin Bo Shen Xing Zhu Zheyu Fang | 2018 | Opto-Electronic Advances2018，1，4： | 0 |
| 14 | Distribution Characteristics and Health Risk Assessment of Antimony in Atmospheric Particulates in a Northern City of China显示文摘Over the last several decades,scientists have established a wealth of evidence to demonstrate the risks posed to human health by toxic elements in atmospheric particulate matter(PM).Antimony(Sb),as one of ever ignored PM-bound heavy metals,attracts more and more attentions and has been regarded as one emerging air pollutant with the change of pollution sources of particulate matter.To study the distribution of Sb in PM with different particle sizes is of great practical significance for understanding its source and health risks.In this study,the size distributions of Sb in PM(PM_(2.5),PM_(10)and TSP)in different seasons were studied from July 2018 to May 2019.The high concentration of PM-bound Sb was found and the health risk was evaluated.Sb was enriched in fine particles and showed higher values in winter,which was probably caused by coal combustion and meteorological conditions.It was also found that traffic-related non-exhaust emissions might become another main contribution to fine particle Sb.Health risk assessment demonstrated that the hazard quotient(HQ)of Sb in PM_(2.5)and PM_(10)for children(PM_(2.5):1.54,PM_(10):1.32)exceeded the acceptable threshold and ingestion contributed the most to the HQ for both children and adults. | SHEN Yiwen ZHAO Hao ZHAO Changxian DONG Shuofei CAO Yuanming XIE Jiaojao LYU Meiling YUAN Chungang | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 15 | Recurring Real-Time Monitoring of Inflammations in Living Mice with a Chemiluminescent Probe for Hypochlorous Acid显示文摘Probes for in vivo imaging of hypochlorous acid(HOCl),one of the most important reactive oxygen species in innate immunity,are urgently needed to understand the pathogenesis of autoimmune and neuroinflammatory disorders.As a strong oxidant,HOCl could bleach near-infrared sensors and inactivate luciferase readily,making in vivo imaging overwhelmingly challenging.Via fine-tuning of a selective HOCl sensing moiety,HOCl stable spacer,and bright chemiluminescent scaffold,we have developed HOCl-CL-510 as a highly selective and sensitive probe for HOCl detection both in vitro and in vivo.In particular,we achieved recurring real-time monitoring of HOCl in both acute and chronic inflammation models in living mice,providing a new chemical tool for dynamic monitoring of disease development with reduced usage of experimental animals. | Sen Ye Bowei Yang Meiling Wu Zefeng Chen Jiangang Shen Doron Shabat Dan Yang | 2022 | CCS Chemistry2022，4，6： | 0 |
| 16 | Engineering of Saccharomyces cerevisiae for co-fermentation of glucose and xylose:Current state and perspectives显示文摘The use of non-food lignocellulosic biomass to produce ethanol fits into the strategy of a global circular economy with low dependence on fossil energy resources.Xylose is the second most abundant sugar in lignocellulosic hydrolysate,and its utilization in fermentation is a key issue in making the full use of raw plant materials for ethanol production and reduce production costs.Saccharomyces cerevisiae is the best ethanol producer but the organism is not a native xylose user.In recent years,great efforts have been made in the construction of xy-lose utilizing S.cerevisiae strains by metabolic and evolutionary engineering approaches.In addition,managing global transcriptional regulation works provides an effective means to increase the xylose utilization capacity of recombinant strains.Here we review the common strategies and research advances in the research field in order to facilitate the researches in xylose metabolism and xylose-based fermentation. | Yali Qiu Meiling Wu Haodong Bao Weifeng Liu Yu Shen | 2023 | Engineering Microbiology2023，3，3： | 0 |
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