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| 1 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 2 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | CRISPR/Cas9:A powerful tool for crop genome editing显示文摘The CRISPR/Cas9 technology is evolved from a type II bacterial immune system and represents a new generation of targeted genome editing technology that can be applied to nearly all organisms. Site-specific modification is achieved by a single guide RNA(usually about 20nucleotides) that is complementary to a target gene or locus and is anchored by a protospaceradjacent motif. Cas9 nuclease then cleaves the targeted DNA to generate double-strand breaks(DSBs), which are subsequently repaired by non-homologous end joining(NHEJ) or homology-directed repair(HDR) mechanisms. NHEJ may introduce indels that cause frame shift mutations and hence the disruption of gene functions. When combined with double or multiplex guide RNA design, NHEJ may also introduce targeted chromosome deletions,whereas HDR can be engineered for target gene correction, gene replacement, and gene knock-in. In this review, we briefly survey the history of the CRISPR/Cas9 system invention and its genome-editing mechanism. We also describe the most recent innovation of the CRISPR/Cas9 technology, particularly the broad applications of modified Cas9 variants, and discuss the potential of this system for targeted genome editing and modification for crop improvement. | Gaoyuan Song Meiling Jia Kai Chen Xingchen Kong Bushra Khattak Chuanxiao Xie Aili Li Long Mao | 2016 | The Crop Journal2016，4，2： | 4 |
| 4 | Wheat functional genomics in the era of next generation sequencing: An update显示文摘Bread wheat is not only an important cereal crop but also a model for study of an allopolyploid plant with a large, highly repetitive genome. Advances in next-generation sequencing(NGS) technology provide needed throughput to conquer the enormous size of the wheat genome. Multiple high quality reference genome sequences will soon be available. Full-scale wheat functional genomics studies are dawning. In this review we highlight the available tools and methodologies for wheat functional genomics research developed with the assistance of NGS technology and recent progress, particularly the concerted effort in generating multiple reference genomes, strategies to attain genome-wide genetic variation, genome-wide association studies, mutant population generation, and NGS-supported gene cloning and functional characterization. These resources and platforms lay a solid foundation for wheat research, leading to a new era of wheat functional genomics that will bridge the gap between genotype and phenotype.Dissection of wheat genomes and gene functions should assist in genomics-assisted selection and facilitate breeding of elite varieties for sustainable agriculture in China and the world. | Meiling Jia Jiantao Guan Zhiwen Zhai Shuaifeng Geng Xueyong Zhang Long Mao Aili Li | 2018 | The Crop Journal2018，6，1： | 3 |
| 5 | Copper‑Based Catalysts for Electrochemical Carbon Dioxide Reduction to Multicarbon Products显示文摘Electrochemical conversion of carbon dioxide into fuel and chemicals with added value represents an appealing approach to reduce the greenhouse effect and realize a carbon-neutral cycle,which has great potential in mitigating global warming and effectively storing renewable energy.The electrochemical CO_(2) reduction reaction(CO_(2)RR)usually involves multiproton coupling and multielectron transfer in aqueous electrolytes to form multicarbon products(C_(2+) products),but it competes with the hydrogen evolution reaction(HER),which results in intrinsically sluggish kinetics and a complex reaction mechanism and places higher requirements on the design of catalysts.In this review,the advantages of electrochemical CO_(2) reduction are briefly introduced,and then,different categories of Cu-based catalysts,including monometallic Cu catalysts,bimetallic catalysts,metal-organic frameworks(MOFs)along with MOF-derived catalysts and other catalysts,are summarized in terms of their synthesis method and conversion of CO_(2) to C2+products in aqueous solution.The catalytic mechanisms of these catalysts are subsequently discussed for rational design of more efficient catalysts.In response to the mechanisms,several material strategies to enhance the catalytic behaviors are proposed,including surface facet engineering,interface engineering,utilization of strong metal-support interactions and surface modification.Based on the above strategies,challenges and prospects are proposed for the future development of CO_(2)RR catalysts for industrial applications. | Fangfang Chang Meiling Xiao Ruifang Miao Yongpeng Liu Mengyun Ren Zhichao Jia Dandan Han Yang Yuan Zhengyu Bai Lin Yang | 2022 | Electrochemical Energy Reviews2022，5，3： | 2 |
| 6 | Differentially expressed genes in early gestational chorionic villi after administration of mifepristone显示文摘 | Liu Meiling ghi Xinquan Jia Mengchun | 2011 | Gynecological Endocrinol2011，27，6： | 1 |
| 7 | Catalytic Combustion of Formaldehyde on Gold/Iron-Oxide Catalysts显示文摘 | Li Changyan Shen Yuenian Jia Meiling | 2008 | Catal Commun2008，9，3： | 1 |
| 8 | Differentially expressed genes in early gestational chorionic villi after administration of mifepristone显示文摘 | Liu Meiling Shi Xinquan Jia Mengchun | 2011 | Gynecological Endocrinol2011，27，6： | 1 |
| 9 | The soft glumes of common wheat are sterile-lemmas as determined by the domestication gene Q显示文摘The Q gene in common wheat encodes an APETALA2(AP2) transcription factor that causes the free threshing attribute. Wheat spikelets bearing several florets are subtended by a pair of soft glumes that allow free liberation of seeds. In wild species, the glumes are tough and rigid,making threshing difficult. However, the nature of these 'soft glumes', caused by the domestication allele Q is not clear. Here, we found that over expression of Q in common wheat leads to homeotic florets at glume positions. We provide phenotypic, microscopy, and marker genes evidence to demonstrate that the soft glumes of common wheat are in fact lemma-like organs, or so-called sterile-lemmas. By comparing the structures subtending spikelets in wheat and other crops such as rice and maize, we found that AP2 genes may play conserved functions in grasses by manipulating vestigial structures, such as floret-derived soft glumes in wheat and empty glumes in rice. Conversion of these seemingly vegetative organs to reproductive organs may be useful in yield improvement of crop species. | Gaoyuan Song Guoliang Sun Xingchen Kong Meiling Jia Ke Wang Xingguo Ye Yun Zhou Shuaifeng Geng Long Mao Aili Li | 2019 | The Crop Journal2019，7，1： | 1 |
| 10 | Atomically dispersed Fe sites on hierarchically porous carbon nanoplates for oxygen reduction reaction显示文摘Developing cost-effective,robust and stable non-precious metal catalysts for oxygen reduction reaction(ORR) is of paramount importance for electrochemical energy conversion devices such as fuel cells and metal-air batteries.Although Fe-N-C single atom catalysts(SACs) have been hailed as the most promising candidate due to the optimal binding strength of ORR intermediates on the Fe-N_(4) sites,they suffer from serious mass transport limitations as microporous templates/substrates,i.e.,zeolitic imidazolate frameworks(ZIFs),are usually employed to host the active sites.Motivated by this challenge,we herein develop a hydrogen-bonded organic framework(HOF)-assisted pyrolysis strategy to construct hierarchical micro/mesoporous carbon nanoplates for the deposition of atomically dispersed Fe-N_(4) sites.Such a design is accomplished by employing HOF nanoplates assembled from 2-aminoterephthalic acid(NH_(2)-BDC) and p-phenylenediamine(PDA) as both soft templates and C,N precursors.Benefitting from the structural merits inherited from HOF templates,the optimized catalyst(denoted as Fe-N-C SAC-950) displays outstanding ORR activity with a high half-wave potential of 0.895 V(vs.reversible hydrogen electrode(RHE)) and a small overpotential of 356 mV at 10 mA cm^(-2) for the oxygen evolution reaction(OER).More excitingly,its application potential is further verified by delivering superb rechargeability and cycling stability with a nearly unfading charge-discharge gap of 0.72 V after 160 h.Molecular dynamics(MD) simulations reveal that micro/mesoporous structure is conducive to the rapid mass transfer of O_(2),thus enhancing the ORR performance.In situ Raman results further indicate that the conversion of O_(2) to~*O_(2)-the rate-determining step(RDS) for Fe-N-C SAC-950.This work will provide a versatile strategy to construct single atom catalysts with desirable catalytic properties. | Ruixue Zheng Qinglei Meng Hao Zhang Teng Li Di Yang Li Zhang Xiaolong Jia Changpeng Liu Jianbing Zhu Xiaozheng Duan Meiling Xiao Wei Xing | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 11 | Breeding and Evaluation of New Iron Yam (Dioscorea opposita Thunb) Varieties显示文摘[Objective] This study was conducted to develop some new iron yam(Dioscorea opposita) varieties with excellent cooking, eating and nutritional qualities.[Method] The fresh weight per plant, drying rate, dry weight per plant, yield, allantoin content, water soluble extract content and disease resistance of seven new iron yam cultivars(No.1, No.2, No.4, No.6, No.8, No.9 and No.10) obtained through spaceflight mutation breeding were measured and compared with control(No.11).Then, the nutrition quality of two elite cultivars No. 6 and No.10 was determined by comparing with the control. [Result] The eight iron yam cultivars ranked in descending order of their fresh weight per plant as follows: No.6(0.255 kg)>No.10(0.254 kg)>No.4(0.242 kg)>No.9(0.237 kg)>No.1(0.233 kg)>No.11(0.206 kg)>No.2(0.191 kg)>No.8(0.157 kg). There was no significant difference in fresh weight per plant between No.6 and No.10, but extremely significant difference between No.6 and the control,No.10 and the control. The eight iron yam cultivars ranked in descending order of their drying rate as follows: No.2(32.641%)>No.10(32.230%)>No.9(28.223%)>No.6(25.174%)>No.8(25.122%)>No.11(25.043%)>No.1(24.291%)>No.4(20.234%). The drying rate of both No.6 and No.10 was higher than that of the control. The eight iron yam cultivars ranked in descending order of their dry weight per plant as follows:No.10(0.082 kg)>No.9(0.067 kg)>No.6(0.064 kg)>No.2(0.062 kg)>No.1(0.056 kg)>No.11(0.052 kg)>No.4(0.049 kg)>No.8(0.039 kg). The dry weight per plant of both No.6and No.10 is higher than that of the control. The eight iron yam cultivars ranked in descending order of their allantoin content as follows No.6(0.484%)>No.4(0.467%)>No.10(0.399%) >No.11(0.386%) >No.9(0.378%) >No.8(0.350%) >No.2(0.342) >No.1(0.325%). The allantoin content of No.6 was significantly higher than that of No.10 and the control. There was significant difference in allantoin content between No.6and No.10, but no significant difference between No 10 and the control. The eight iron yam cultivars ranked in descending order of their extract content as follows No.6(20.49%)>No.2(16.01%)>No.4(15.54%)>No.10(15.35%)>No.1(14.48%)>No.11(14.10%)>No.9(13.88%)>No.8(11.87%). The extract content of No.6 exhibited extremely significant difference with that of No.10 and the control, and the extract content of No.10 was also significantly different from that of the control. The taste of No.10 was dry, soft, floury, sweet and fragrant, better than that of the other seven cultivars.No.6 had the strongest resistance to Gloeosporium pestis and Cylindrosporium dioscoreae. No.10 had a middle resistance to G. pestis and a strong resistance to C. dioscoreae. No.6 and No.10 had higher contents of starch, reducing sugar, protein and ash, lower water content and better nutrition quality than the control.[Conclusion] No.10 can be popularized as a new variety of edible iron yam, and No.6as a new variety of medicinal iron yam. | Sufang DUAN Jianjun LI Meiling REN Jun WANG Guolun JIA Shuwu SUN | 2015 | Agricultural Science & Technology2015，16，10： | 0 |
| 12 | A simple hydroxypyridine ionic liquids for conversion of CO_(2)into quinazoline-2,4(1H,3H)-diones under atmospheric conditions显示文摘The transformation of CO_(2)into high value-added product is a promising pathway for utilizing CO_(2).However,the process tends to require harsh reaction conditions owing to CO_(2)chemical inertness.Designing a high efficiency catalytic system with environmentally benign characteristic are important determinants.In this work,protic ionic liquids[TMG][2-OPy]were prepared via one-step neutralization between 1,1,3,3-tetramethylguanidine and 2-hydroxypyridine,applying to the domain of synthesizing quinzoline-2,4(1 H,3H)-diones from CO_(2)and 2-aminobenzontiles without any solvent or metal,achieving the yield of 97%at 90℃for 8 h under atmospheric.A series of substrates with good to acceptable yield were detected,revealing the generality and universality of the catalyst.Furthermore,the system could be facilely reused for at least six runs,retaining the yield of 94%.A preliminary kinetic equation is calculated with the activation energy of 68 kJ·mol^(-1),and a plausible reaction mechanism was put forward.This study highlights that the[TMG][2-OPy]enables to activate CO_(2)carboxylation efficiently. | Bowen Jiang Meiling Weng Jigang An Yuewei Fan Jia Liu Ying Liu Ting Yu Leizhi zheng Guoqiang Yang Zhibing Zhang | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
| 13 | Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy显示文摘Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA vaccines.Selective expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA vaccines.Inspired by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered intravenously.When the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA translation.The mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in hepatocytes.Immunization with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma model.Our natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy. | Fazhan Wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming Wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin | 2024 | Nano Research2024，17，3： | 0 |
| 14 | Recent Advances in Stability Improvement Strategies of M-N_(x)/C Catalysts Towards Oxygen Reduction Reaction显示文摘Although fuel cells possess advantages of high energy conversion efficiency and zero-carbon emission,their large-scale commercialization is restricted by expensive and scarce platinum(Pt)catalysts.Metal-nitrogen-carbon(M-Nx/C)catalysts are hailed as the most promising candidates to replace Pt due to their considerable oxygen reduction reaction(ORR)activity and low cost.Despite tremendous progress in terms of active site identification and activity improvement being achieved in the past few decades,the M-Nx/C catalysts still suffer from insufficient durability,which drastically limits their practical application.In this regard,understanding degradation mechanisms and customizing stabilization strategies are of significant importance yet challengeable.In this review,we summarize the recent advances in the stability improvement of M-Nx/C catalysts.The stability test protocols of the M-Nx/C are firstly introduced.Subsequently,with the combination of advanced ex situ and in situ characterization techniques and density functional theory calculation,we present a comprehensive overview of the main degradation mechanisms during ORR process.Aiming at these deactivation issues,a variety of novel improvement strategies are developed to enhance the stability of M-Nx/C.Finally,the current challenges and prospects to design highly stable M-Nx/C catalysts are also proposed. | Xiaolong Jia Qinglei Meng Ruixue Zheng Xiaohui Liu Yaling Zhao Changpeng Liu Meiling Xiao Wei Xing | 2023 | Renewables2023，1，6： | 0 |
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