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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | NGF combined with OGD induces neural ischemia tolerance in PC12 cells[cells显示文摘 | Mei CL Mang J Xu ZX | | 0，，09： | 1 |
| 3 | Second primary malignan- cies after autologous hematopoietic cell transplantation for multi- ple myeloma显示文摘 | Krishnan AY Mei M Sun CL | 2013 | Biol Blood Marrow Transplant2013，19，2： | 1 |
| 4 | Epidemiology of cardiovascular risk in Chinese chronic kidney disease patients显示文摘 | Ma ZG Mei CL | 2005 | Zhonghua Yi Xue Za Zhi2005，85，11： | 1 |
| 5 | Reverse correlation between ankle-brachial index and left ventricular hypertrophy in patients on maintenance heamodialysis显示文摘 | Fu WC Ye CY Mei CL | 2006 | Nephrology2006，11，1： | 1 |
| 6 | Entropy of interval-valued fuzzy sets based on distance and its relationship with similarity measure 显示文摘 | Zhartg H Y Zhang WX Mei CL | 2009 | Knowledge-Based Systems2009，22，6： | 1 |
| 7 | Statistical Tests for Spatial Nonstationarity Based on the Geographically Weighted Regression Model 显示文摘 | Leung Y Mei CL Zhang WX | 2000 | Environment and Planning A2000，，32： | 1 |
| 8 | Effects of RNA interference targeting Smad7 on nerve cells ischemic injury induced in PC12 cells显示文摘 | Mei CL Mang J He JT | 2012 | Af- riean Journal of Biotechnology2012，11，13： | 1 |
| 9 | Neuroprotective effects of exogenous activin A on oxygen-glucose deprivation in PC12 cells显示文摘 | He JT Mang J Mei CL | 2012 | Molecules2012，17，1： | 1 |
| 10 | CDC growth charts:United States显示文摘 | Kuczmarski RJ Ogden CL Grummer-Strawn LM Flegal KM Guo SS Wei R Mei Z Curtin LR Roche AF Johnson CL | | 0，，314： | 1 |
| 11 | Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic in- jury in PC12 cells显示文摘 | Mang J Mei CL Wang JQ | 2013 | Molecules2013，18，12： | 1 |
| 12 | Screening for Intracranial Aneurysm in 355 Patients With Autosomal-Dominant Polycystic Kidney Disease 显示文摘 | Xu HW Yu SQ Mei CL | 2011 | Stroke2011，42，1： | 1 |
| 13 | ACE 2,a new regulator of the renin-angiotensin system显示文摘 | Bruell LM Johnston CL Tikellis C Cooper MEI | 2004 | Trends Endocrinol Metab2004，15，4： | 1 |
| 14 | Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease显示文摘 | Xu HW Yu SQ Mei CL | | 0，，： | 1 |
| 15 | MicroRNA-146a inhibits glioma development by targeting Notchl 显示文摘 | Mei J Bachoo R Zhang CL | 2011 | Mol Cell Biol2011，31，17： | 1 |
| 16 | Comparisons between oral pulse alfacalcidol therapy and daily therapy in maintenance hemodialysis patients with secondary hyperparathyroidism: a randomized, controlled, and multicenter study 显示文摘 | Gu Y Ding F Chen N Mei CL Qian JQ Wang xY | 2005 | Ren Fail2005，27，2： | 1 |
| 17 | Reverse correlation between ankle-brachial index and left ventricular hypertrophy in patients on maintenance heamodialysis显示文摘 | Fu WC Ye CY Mei CL | 2006 | Nephrology2006，11，1： | 1 |
| 18 | MicroRNA-146a inhibits glioma development by targeting Notch1显示文摘 | Mei J Bachoo R Zhang CL | 2011 | Mol Cell Biol2011，31，17： | 1 |
| 19 | Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease显示文摘 | Xu HW Yu SQ Mei CL | | 0，，： | 1 |
| 20 | Screening for Intracranial Aneurysm in 355 Patients With Autosomal-Dominant Polycystic Kidney Disease显示文摘 | Xu HW Yu SQ Mei CL | 2011 | stroke2011，42，1： | 1 |
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