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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Urethroscopic realignment of ruptured bulbous urethra显示文摘 | Sun YH Xu CL Gao X | 2000 | J Urol2000，164，： | 1 |
| 3 | Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy显示文摘 | Sun MZ Deckers CL Liu YX | | 0，，02： | 1 |
| 4 | A survey in rural China of parent-absence through migrant working:the impaet on their children's self-concept and loneliness 显示文摘 | Liu L J Sun X Zhang CL | 2010 | BMC Public Health2010，10，： | 1 |
| 5 | Second primary malignan- cies after autologous hematopoietic cell transplantation for multi- ple myeloma显示文摘 | Krishnan AY Mei M Sun CL | 2013 | Biol Blood Marrow Transplant2013，19，2： | 1 |
| 6 | Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy显示文摘 | AMLING CL RIFFENBURGH RH SUN L | 2004 | J Clin Oncol2004，22，3： | 1 |
| 7 | Li distribution and mode of occurrenc- es in Li-bearing coal seam 6 from the Guanbanwusu Mine, Inner Mongo- lia, Northern China显示文摘 | Sun YZ Zhao CL Li YH | 2012 | Energy Exploration and Exploitation2012，30，1： | 1 |
| 8 | Opposing effects of dieta- ry n-3 and n-6 fatty acids on mammary carcinogenesis:The singapore Chinese health study 显示文摘 | Gago-Dominguez M Yuan JM Sun CL | 2003 | Br J Cancer2003，89，9： | 1 |
| 9 | Effects of dietary mixtures of amino acids on fetal growth and fetal amino acids pools in experimental maternal phenylketonuria显示文摘 | Austic RE Sun CL Strupp BJ | 1999 | Am J Clin Nutr1999，69，4： | 1 |
| 10 | Ureteroscope realignment of ruptured bulbous urethra显示文摘 | Sun YH Xu CL Gao X | 2000 | J Urol2000，164，5： | 1 |
| 11 | Angiotenensin I-converting enzyme(ACE) gene polymorphismad breast cancer risk among Chinese women in Singapore 显示文摘 | Koh WP Yuan J M Sun CL | 2003 | Cancer Res2003，63，3： | 1 |
| 12 | A myocardial lineage derives from tbxl8 epicardial cells 显示文摘 | Cai CL Martin JC Sun Y | 2008 | Nature2008，454，7200： | 1 |
| 13 | Intraurethral brachytherapy for prevention of recurrent urethral stricture after internal urethrotomy or transurethral resection of scar 显示文摘 | Sun YH Xu CL Gao X | 2001 | J En- douro12001，15，： | 1 |
| 14 | LL-37 expression in the skin in syste-mic lupus erythematosus 显示文摘 | Sun CL Zhang FZ Li P | 2011 | Lupus2011，20，9： | 1 |
| 15 | Angiotensin I- converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore 显示文摘 | Koh WP Yuan JM Sun CL | 2011 | Clin Biochem2011，44，1415： | 1 |
| 16 | Monoclonal antidoublestranded DNA autoantibody stimulates the expression and release of IL-1 beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis 显示文摘 | Sun KH Yu CL Tang S J | 2000 | Immunology2000，99，3： | 1 |
| 17 | Urinary tea polyphenols in relation to gastric and esophageal cancers:a prospective study of men in Shanghai,China显示文摘 | Sun CL Yuan JM Lee MJ | 2002 | Carcinogenesis2002，23，9： | 1 |
| 18 | Angiotensin I-converting enzyme(ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore显示文摘 | Koh WP Yuan JM Sun CL | | 0，，03： | 1 |
| 19 | Li distribution and mode of oceur- renees in Li-bearing coal seam 6 from the Guanbanwusu Mine, Inner Mongolia, Northern China显示文摘 | Sun YZ Zhao CL Li YH | 2012 | Energy Exploration and Exploitation2012，30，1： | 1 |
| 20 | Activation of calcium-sensing re- ceptor increases TRPC3/6 expression in T lymphocyte in sepsis显示文摘 | Wu QY Sun MR Wu CL | 2015 | Mol Immunol2015，64，1： | 1 |
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