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| 1 | A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。 | Amy E Monaghan Iain J McEwan | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 2 | Past,present and future of industrial plantation forestry and implication on future timber harvesting technology显示文摘Plantation forests are established,and expanding,to satisfy increasing global demand for timber products.Shifting societal values,such as safety,productivity,environmental,quality and social are influencing the plantation forestry sector.This is primarily driven through an ever increasing world population,which in turn influences the way nations view the value systems by which they live.More people require more resources-also forest products.Also,the availability of information is influencing the pace of technological development.These changes could result in a difference in the management of plantations that could affect the forest engineering systems of the future.This review aimed to summarize the current status of plantation forests;summarize future developments and possible scenarios in forest plantation management for the various products;and assess whether these developments in a plantation environment could affect the harvesting systems used.Factors influencing the form of plantations include the type and nature of the plantation owner;the change in demand for different and new forest products;climate change factors,including the use of biomass for energy,carbon sequestration and trading;ecosystem services and other products and services;and sustainability certification of forest management.The impact and influence of these factors were summarised into a series of key drivers that will influence the technology used in harvesting machines,as well as the choice of harvesting machines,systems and methods.These drivers were the effect of variations in tree size,the expansion of plantation areas onto more difficult terrain,diversity in plantation design,increased attention towards site impacts and the increased use of biomass for energy.Specific information is provided regarding how the harvesting systems could be affected. | Andrew McEwan Enrico Marchi Raffaele Spinelli Michal Brink | 2020 | Journal of Forestry Research2020，31，2： | 3 |
| 3 | Raised paraspinal muscle activity reduces rate of stature recovery after loaded exercise in individuals with chronic low back pain显示文摘 | Emma L. Healey Neil E. Fowler Adrian M. Burden Islay M. McEwan | 2005 | Archives of Physical Medicine and Rehabilitation2005，，4： | 2 |
| 4 | Stiffened panel stability behaviour and performance gains with plate prismatic sub-stiffening显示文摘 | D. Quinn A. Murphy W. McEwan F. Lemaitre | 2009 | Thin-Walled Structures2009，，12： | 2 |
| 5 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 6 | An experimental evaluation of fire history reconstruction using dendrochronology in white oak (quercus alba)显示文摘 | Mcewan R W Huchinson T F Ford R D | 2007 | Canadian Journal of Forest research2007，37，4： | 1 |
| 7 | Molecular mechanisms of androgen receptor-mediated gene regulation:structure-function analysis of the AF-1 domain显示文摘 | McEwan IJ | 2004 | Endocrine-Related Cancer2004，11，： | 1 |
| 8 | Matrix metalloproteinases and cardiovascular disease 显示文摘 | Dollery CM McEwan JR Henney AM | 1995 | Circ Res1995，77，5： | 1 |
| 9 | Differential effects of angiotensin 1] on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo显示文摘 | McEwan PE Gray GA Sherry L | 1998 | Circulation1998，98，24： | 1 |
| 10 | Crust strength: a wind tunnel study of the effect of impact by sahating particles on cohesive soil surfaces 显示文摘 | Rice M A Mcewan I K | 2001 | Earth Surface Processes and Landforms2001，26，： | 1 |
| 11 | Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep显示文摘 | Davis G H McEwan J C Fennessy P F | 1991 | Biol Reprod1991，44，4： | 1 |
| 12 | Crystal structure of the factor XI zymogen reveals a pathway for transactivation显示文摘 | Papagrigoriou E McEwan PA Walsh PN | 2006 | Nat Struct Mol Biol2006，13，6： | 1 |
| 13 | Structural and functional alterations in the androgen receptor in spinal bulbar muscular atrophy显示文摘 | McEwan IJ | 2001 | Biochem Soc Transactions2001，29，： | 1 |
| 14 | A role for ubiquitin in selective autophagy显示文摘 | Kirkin V McEwan DG Novak I | 2009 | Mol Cell2009，34，： | 1 |
| 15 | Recruitment of Rural Teachers in Developing Countries: An Economic Analysis 显示文摘 | Patrick J McEwan | 1999 | Teaching and Teacher Education1999，，15： | 1 |
| 16 | Rumen micro- bial population dynamics in response to photoperiod 显示文摘 | McEwan NR Abecia L Regensbogenova M | 2005 | Lett Appl Microbial2005，41，1： | 1 |
| 17 | The effects of prescribed fire and silvicultural thinning on the aboveground carbon stocks and net primary production of overstory trees in an oak-hickory ecosystem in southern Ohio 显示文摘 | Chiang J M McEwan R W Yaussy D A | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 18 | The validity of clinical measures of patella position 显示文摘 | McEwan I Herrington L Thom J | 2007 | Manual Ther2007，12，3： | 1 |
| 19 | Natu ral products as manipulators of rumen fermentation 显示文摘 | Wallace R J McEwan N R Mclntosh F M | 2002 | Asian Australasian Journal of Animal Science2002，15，： | 1 |
| 20 | Resuits of a randomized phase Ⅲ trial to eval- uate the efficacy of strontium - 89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer 显示文摘 | Porter AT McEwan AJ Powe JE | 1993 | Int J Radiat Oncol Biol Phys1993，25，5： | 1 |
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