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| 1 | Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs显示文摘Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species(ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: 'Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?' The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. | Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi | 2016 | Chinese Journal of Cancer Research2016，28，4： | 3 |
| 2 | High vesicular cholesterol and protein in bile are associated with formation of cholesterol but not pigment gallstones显示文摘 | Dr. Kazuo Chijiiwa MD Ichio Hirota MD Hirokazu Noshiro MD | 1993 | Digestive Diseases and Sciences1993，，1： | 1 |
| 3 | Treadmill trainingwith body weight support:Its effect on Parkinson's disease显示文摘 | Ichio M Yesuyuki F Yoshishige U | 2000 | Arch Phys Med Rehabil2000，81，： | 1 |
| 4 | Performance of integrated FDG–PET/contrast-enhanced CT in the diagnosis of recurrent ovarian cancer: comparison with integrated FDG–PET/non-contrast-enhanced CT and enhanced CT显示文摘 | Kazuhiro Kitajima Koji Murakami Erena Yamasaki Yasushi Domeki Yasushi Kaji Ichio Fukasawa Noriyuki Inaba Narufumi Suganuma Kazuro Sugimura | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，8： | 1 |
| 5 | Idiopathic sudden hearing loss in patients with type 2 diabetes显示文摘 | Michiaki Fukui Yoshihiro Kitagawa Naoto Nakamura Mayuko Kadono Shin-ichi Mogami Masayoshi Ohnishi Chizuko Hirata Naoko Ichio Katsuya Wada Chiyoko Kishimoto Hirofumi Okada Hirofumi Miyata Toshikazu Yoshikawa | 2003 | Diabetes Research and Clinical Practice2003，，3： | 1 |
| 6 | Loss of 17p,mutation of the p53 gene,and overexpression of P53 protein in esophageal squamous cell carcinomas显示文摘 | Takashi W Ichio S Masayuki I | 1993 | Cancer Res1993，53，4： | 1 |
| 7 | Reactivity and durability of iron oxide high temperature desulfurization sorbents 显示文摘 | SASAOKA E SAKAMOTO M ICHIO T | 1993 | Energy & Fuels1993，7，63： | 1 |
| 8 | Treadmill training with body weight support:Its effect on Parkinson's disease显示文摘 | Ichio M Yasuyuki F Yoshishige U | 2000 | Arch Phys Med Rehabil2000，81，： | 1 |
| 9 | High-temperature hydrogen sulfide removal from coal-derived gas by iron ore显示文摘 | Sasaoka E Ichio T Kasaoka S | 1992 | Energy & Fuels1992，6，5： | 1 |
| 10 | A random amplified polymorphic DNA (RAPD) primer to assist the identification of a selected strain,aizu K-111 of Panax ginseng and the sequence amplified显示文摘 | Yukiko TK Isao A Ichio I | 2001 | Biol Pharm Bull2001，24，： | 1 |
| 11 | Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors显示文摘 | Peng Mi Daisuke Kokuryo Horacio Cabral Michiaki Kumagai Takahiro Nomoto Ichio Aoki Yasuko Terada Akihiro Kishimura Nobuhiro Nishiyama Kazunori Kataoka | 2014 | Journal of Controlled Release2014，，： | 1 |
| 12 | Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics显示文摘 | Bakalova Ichio Aoki Lubomir Spasov Daisuke Kokuryo Zhivko Zhelev | 2011 | International Journal of Nanomedicine (default)2011，，： | 1 |
| 13 | Design of a maximum power tracking system for wind-energy-conversion applications 显示文摘 | EFI'ICHIOS K KOSTAS K | 2006 | IEEE Transactions on Industrial Electronics2006，53，2： | 1 |
| 14 | Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging显示文摘 | Sumitaka Hasegawa Yukie Morokoshi Atsushi B. Tsuji Toshiaki Kokubo Ichio Aoki Takako Furukawa Ming-Rong Zhang Tsuneo Saga | 2014 | Molecular Oncology2014，，： | 1 |
| 15 | Reactivity and durability of iron oxide high temperature desulfurization显示文摘 | SASAOKA E SAKAMOTO M ICHIO T KASAOKA S SAKATA Y | 1993 | Energy Fuels1993，7，5： | 1 |
| 16 | A case report :rare case of primary transitional cell carcinoma of the fallopian tube 显示文摘 | Takeuchi S Hirano H Ichio T | 1999 | J Obstet Gynaecol Res1999，25，1： | 1 |
| 17 | 一种新的病毒TTV,在产科和围产医学的临床意义显示文摘目的:为了研究TTV(一种新的NMA病毒)在围产期对孕妇的危害,检查日本孕妇TTV的感染情况、孕妇肝功能(sALT/sAST)及其后代,包括回顾性和前瞻性研究。研究对象及方法:反复检测195名非携带HBV和HCV孕妇(NBCPW组),84名携带HBV和/或HCV孕妇(BCCPW组)以及TTV-DNA阴性孕妇(对照组)的TTV-DNA和肝功能。NBCPW组携带TTV孕妇分娩14个新生儿。 | Shihou H Michiyo I Kyoko O Ichio F Hiroshi W | 2010 | 中国产前诊断杂志(电子版)2010，，4： | 1 |
| 18 | Characteristics of high-carbon high hpeed hteel rolls for hot strip mill显示文摘 | Yoshikazu Sano Toshiyuki Hattorl M ichio Haga | 1992 | ISIJ International1992，32，11： | 1 |
| 19 | A case report:rare case of primary transitional cell carcinoma of the fallopian tube显示文摘 | Takeuchi S Hirano H Ichio T | 1999 | J Obstet Gynaecol Res1999，25，1： | 1 |
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