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| 1 | Early diabetic neuropathy:Triggers and mechanisms显示文摘Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the most frequent and troublesome complications of diabetes mellitus. It is the major reason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presenta- tions of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glu- cose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has ac- cumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, cor- relation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our un- derstanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on clinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia. | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | World Journal of Gastroenterology2007，13，2： | 55 |
| 2 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 3 | Special nanostructures in Al-Mg alloys subjected to high pressure torsion显示文摘Deformation twins and stacking faults were observed in nanostructure Al-Mg alloys subjected to high pressure torsion.These observations are surprising because deformation twinnings have never been observed in their coarse-grained counterparts under normal conditions.Experimental evidences are introduced on non-equilibrium grain boundaries,deformation twinnings and partial dislocation emissions from grain boundaries.Some of these features can be explained by the results reported from molecular-dynamics simulations of pure FCC metals.Special emphasis is laid on the recent observations of high density hexagonal and rhombic shaped nanostructures with an average size of 3 nm in the Al-Mg alloys processed by high pressure torsion.A possible formation process of these nanostructures is proposed based on molecular-dynamics simulations. | 刘满平 Hans J.ROVEN 刘新涛 Maxim MURASHKIN Ruslan Z.VALIEV Tamas UNGáR Levente BALOGH | 2010 | Transactions of Nonferrous Metals Society of China2010，20，11： | 2 |
| 4 | 早期糖尿病神经病变:病因与机制显示文摘外周神经病变,尤其是末梢神经病变,是糖尿病最常见而棘手的并发症之一。它是糖尿病患者发病与死亡的主要原因,还常与衰弱性疼痛相关。遗憾的是,我们对糖尿病末梢神经病变自然史与发病机理的了解仍然有限。本文介绍2007年1月《World J Gastroenterol》杂志上有关该病的早期病因与机制。 | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | 继续医学教育2007，21，5： | 1 |
| 5 | A Common Pesticide Decreases Foraging Success and Survival in Honey Bees显示文摘 | MICKAEL H MAXIME B FABRICE R | 2012 | Science2012，336，6079： | 1 |
| 6 | The Ability of Stroke Volume Variations Obtained with Vigileo/FloTrac System to Monitor Fluid Responsiveness in Mechanically Ventilated Patients显示文摘 | Maxime Cannesson Henri Musard Olivier Desebbe Cécile Boucau Rémi Simon Roland Hénaine Jean-Jacques Lehot | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 7 | Catalytic combustion of methane over palladium-based catalysts 显示文摘 | Ciuparu D Maxim R L Altman E | 2002 | Catalysis Review2002，44，： | 1 |
| 8 | Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking 显示文摘 | Maxime D H Camilla L C Philippe R | 2003 | Science2003，302，： | 1 |
| 9 | Intelligent Content-based Retrieval for P2P Networks显示文摘 | Maxim R Siu Cheung Hui | 2003 | Proceedings of International Conference on Cyberworlds2003，3，5： | 1 |
| 10 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 11 | Television-viewing habits and sleep disturbance in school children显示文摘 | Owens J Maxim R McGuinn M | 1999 | Pediatrics1999，104，3： | 1 |
| 12 | Parental and self-report of sleep in children with attention-deficit/hyperactivity disorder显示文摘 | Owens JA Maxim R Nobile C | 2000 | Arch Pediatr Adolesc Med2000，154，6： | 1 |
| 13 | Ketamine attenuates neutrophil activation after cardiopulmonary bypass显示文摘 | Genadi Z Rachel L Maxim R | 2002 | Anesth Analg2002，95，3： | 1 |
| 14 | Workplace monitoring of occupational exposure to refractory ceramic fiber-a 17-year , retrospective显示文摘 | MAXIM L D ALLSHOUSE J FAIRFAX R E | 2008 | Inhal Toxicol2008，20，3： | 1 |
| 15 | Television-viewing habits and sleep disturbance in school children显示文摘 | Owens J Maxim R McGuinn M | 1999 | Pediatrics1999，104，3： | 1 |
| 16 | Parental and self-report of sleep in children with attention - deficit/hyperactivity disorder 显示文摘 | Owens JA Maxim R Nobile C | 2000 | Arch Pediatr Adolesc Med2000，154，6： | 1 |
| 17 | Bifunctional Fe3O4/ZnS:Mn composite nanoparticles显示文摘 | JUAN B H MAXIME J F BRAD R W | 2013 | Material Letters2013，98，： | 1 |
| 18 | Tat(48-60) peptide amino acid sequence is not unique in its cell penetrating properties and cell-surface glycosaminoglycans inhibit its cellular uptake显示文摘 | Astrid Subrizi Eva Tuominen Alex Bunker Tomasz Róg Maxim Antopolsky Arto Urtti | 2011 | Journal of Controlled Release2011，，2： | 1 |
| 19 | Television-viewing habits and sleep disturbance in school children显示文摘 | Maxim R MeGuinn M | 1999 | Pediatrics1999，104，3： | 1 |
| 20 | on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway 显示文摘 | Xu HL Yu XF Qu SC Zhang R Qu XR Chen YP et aL Anti-proliferative effect of juglone from Juglans mand- shurica Maxim | 2010 | EurJ Pharmacol2010，645，13： | 1 |
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