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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | Softwood cuttings for propagation of red alder planting stock显示文摘 | Radwan M A T A Max D W Johnson | 1989 | New For1989，3，： | 1 |
| 4 | Methane hydrate:a frontier for exploration of new gas resources 显示文摘 | Max M D Lowrie A | 1996 | Journal of Petroleum Geology1996，19，2： | 1 |
| 5 | Understanding innovation in small and medium-sized enterprises: A process manifest 显示文摘 | Tim E Rick D Max M | 2005 | Technovation2005，25，10： | 1 |
| 6 | Tectono-sedimentary controls on the likelihood of gas hydrate occurrence near Taiwan显示文摘 | McDonnell S L Max M D Cherkis N Z | 2000 | Marine and Petroleum Geology2000，17，： | 1 |
| 7 | Tectono-sedimentary controls on the likelihood of gashydrate occurrence near Taiwan显示文摘 | MCDONNELL S L MAX M D CHERKIS N Z | 2000 | Marine Petroleum andGeology2000，，： | 1 |
| 8 | Gas hydrates and acoustically laminated sediments:potential environmental cause of anomalously low acoustic bottom loss in deep ocean sediments显示文摘 | Max M D | 1990 | U S Naval Research Laboratory Report1990，9235，66： | 1 |
| 9 | Tectono-sedimentary controls on the likelihood of gas hydrate occurrence near Taiwan显示文摘 | McDonnell S L Max M D Cherkis N Z Czarnecki M F | 2000 | Marine and Petroleum Geology2000，17，： | 1 |
| 10 | Oceanic methane hydrate: Character of the Blake Ridge stability zone and potential for methane extraction显示文摘 | Max M D Dillon W P | 1998 | Journal of Petroleum Geology1998，，21： | 1 |
| 11 | Oceanic Methane Hydrates: A'Frontier'Gas Resource显示文摘 | Max M D Lowrie A | 1996 | Journal of Petroleum Geology1996，19，1： | 1 |
| 12 | Geological control of shallow gas and pockmarks in the norwegian channel;high resolution shallow sub bottom profiling of small scale features显示文摘 | Max M D Schreiber R Cherkis N | | 0，，01： | 1 |
| 13 | Tectono-sedimentary controls on the likelihood of gas hydrate occurrence near Taiwan 显示文摘 | MCDONNELL S L MAX M D CHERKIS N Z | 2000 | Marine and Petroleum Geology2000，17，8： | 1 |
| 14 | Sea floor methane blow-out and global firestorm at the K-T boundary 显示文摘 | Max M D Dillon W P Nishimura C Hurdle B G | 1999 | Geo-Marine Letters1999，18，： | 1 |
| 15 | Magnetic-polarization effect of Pd layers in Fe/Pd multilayers显示文摘 | LI M MAX D PENG C B | 1994 | Physical Review B1994，50，10： | 1 |
| 16 | Oceanic methane hydrate development: reservoir character and extraction显示文摘 | Max M D Lowrie A | 1997 | Offshore Technology Conference Proceedings1997，，5： | 1 |
| 17 | MERRA: NASA’s Modern-Era Retrospective Analysis for Research and Applications显示文摘 | Rienecker Michele M Suarez Max J Gelaro Ronald Todling Ricardo Bacmeister Julio Liu Emily Bosilovich Michael G Schubert Siegfried D Takacs Lawrence Kim Gi-Kong Bloom Stephen Chen Junye Collins Douglas Conaty Austin Da Silva Arlindo Gu Wei | 2011 | Journal of Climate2011，，14： | 1 |
| 18 | Tectono-sedimentary controls on the likelihood of gas hydrate occurrence near Taiwan显示文摘 | McDonnell S L Max M D Cherkis N Z | 2000 | Marine and Petroleum Geology2000，，17： | 1 |
| 19 | Tectonic selling discrimination in clastic sequences :an example from the late Proterozoic Erris group,NWIreland 显示文摘 | Winchester J A Max M D | 1989 | Preeamb Res1989，45，： | 1 |
| 20 | Tectono-sedimentary controls on the likelihood of gas hydrate occurrence near Taiwan显示文摘 | McDonnell S L Max M D Cherkis N Z | 2000 | Marine and Petroleum Geology2000，17，： | 1 |
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