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| 1 | Big Earth Data science:an information framework for a sustainable planet显示文摘The digital transformation of our society coupled with the increasing exploitation of natural resources makes sustainability challenges more complex and dynamic than ever before.These changes will unlikely stop or even decelerate in the near future.There is an urgent need for a new scientific approach and an advanced form of evidence-based decisionmaking towards the benefit of society,the economy,and the environment.To understand the impacts and interrelationships between humans as a society and natural Earth system processes,we propose a new engineering discipline,Big Earth Data science.This science is called to provide the methodologies and tools to generate knowledge from diverse,numerous,and complex data sources necessary to ensure a sustainable human society essential for the preservation of planet Earth.Big Earth Data science aims at utilizing data from Earth observation and social sensing and develop theories for understanding the mechanisms of how such a social-physical system operates and evolves.The manuscript introduces the universe of discourse characterizing this new science,its foundational paradigms and methodologies,and a possible technological framework to be implemented by applying an ecosystem approach.CASEarth and GEOSS are presented as examples of international implementation attempts.Conclusions discuss important challenges and collaboration opportunities. | Huadong Guo Stefano Nativi Dong Liang Max Craglia Lizhe Wang Sven Schade Christina Corban Guojin He Martino Pesaresi Jianhui Li Zeeshan Shirazi Jie Liu Alessandro Annoni | 2020 | International Journal of Digital Earth2020，13，7： | 12 |
| 2 | Cloning and expression of the first gene for biodegrading microcystin LR by Sphingopyxis sp.USTB-05显示文摘Harmful cyanobacterial blooms are a growing environmental problem worldwide in natural waters,the biodegradation is found to be the most efficient method for removing microcystins(MCs) produced by harmful cyanobacteria.Based on the isolation of a promising bacterial strain of Sphingopyxis sp.USTB-05 for biodegrading MCs,we for the first time cloned and expressed a gene USTB-05-A(HM245411) that is responsible for the first step in the biodegradation of microcystin LR(MC-LR) in E.coli DH5α,with a cloning vector of pGEM-T easy and an expression vector of pGEX-4T-1,respectively.The cell-free extracts(CE) of recombinant E.coli DH5α containing USTB-05-A had high activity for biodegrading MC-LR.The initial MC-LR concentration of 40 mg/L was completely biodegraded within 1 hr in the presence of CE with a protein concentration of 0.35 mg/mL.Based on an analysis of the liquid chromatogram-mass spectrum(LC-MS),the enzyme encoded by gene USTB-05-A was found to be active in cleaving the target peptide bond between 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid(Adda) and arginine of MC-LR,and converting cyclic MC-LR to linear MC-LR as a first product that is much less toxic than parent MC-LR,which offered direct evidence for the first step on the pathway of MC-LR biodegradation by Sphingopyxis sp.USTB-05. | Hai Yan Huasheng Wang Junfeng Wang Chunhua Yin Song Max Xiaolu Liu Xueyao Yin | 2012 | Journal of Environmental Sciences2012，24，10： | 6 |
| 3 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 4 | The grapevine kinome:annotation,classification and expression patterns in developmental processes and stress responses显示文摘Protein kinases(PKs)have evolved as the largest family of molecular switches that regulate protein activities associated with almost all essential cellular functions.Only a fraction of plant PKs,however,have been functionally characterized even in model plant species.In the present study,the entire grapevine kinome was identified and annotated using the most recent version of the grapevine genome.A total of 1168 PK-encoding genes were identified and classified into 20 groups and 121 families,with the RLK-Pelle group being the largest,with 872 members.The 1168 kinase genes were unevenly distributed over all 19 chromosomes,and both tandem and segmental duplications contributed to the expansion of the grapevine kinome,especially of the RLK-Pelle group.Ka/Ks values indicated that most of the tandem and segmental duplication events were under purifying selection.The grapevine kinome families exhibited different expression patterns during plant development and in response to various stress treatments,with many being coexpressed.The comprehensive annotation of grapevine kinase genes,their patterns of expression and coexpression,and the related information facilitate a more complete understanding of the roles of various grapevine kinases in growth and development,responses to abiotic stress,and evolutionary history. | Kaikai Zhu Xiaolong Wang Jinyi Liu Jun Tang Qunkang Cheng Jin-Gui Chen Zong-Ming(Max)Cheng | 2018 | Horticulture Research2018，5，1： | 5 |
| 5 | A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas显示文摘 | Jeffrey R. Infante Bradley G. Somer Joon Oh Park Chung-Pin Li Max E. Scheulen Saifuddin M. Kasubhai Do-Youn Oh Yuan Liu Suman Redhu Klaudia Steplewski Ngocdiep Le | 2014 | European Journal of Cancer2014，，： | 4 |
| 6 | Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit显示文摘The exocyst is a well-known complex which tethers vesicles at the cell membrane before fusion. Whether an individual subunit can execute a unique function is largely unknown. Using yeast-two-hybrid(Y2H) analysis, we found that EXO70A1 interacted with the GOLD domain of Patellin3(PATL3). The direct EXO70A1-PATL3 interaction was supported by in vitro and in vivo experiments. In Arabidopsis, PATL3-GFP colocalized with EXO70A1 predominantly at the cell membrane, and PATL3 localization was insensitive to BFA and Try A23. Remarkably, in the exo70 a1 mutant, PATL3 proteins accumulated as punctate structures within the cytosol, which did not colocalize with several endomembrane compartment markers, and was insensitive to BFA. Furthermore, PATL3 localization was not changed in the exo70 e2, PRsec6 or exo84b mutants. These data suggested that EXO70A1, but not other exocyst subunits, was responsible for PATL3 localization,which is independent of its role in secretory/recycling vesicletethering/fusion. Both EXO70A1 and PATL3 were shown to bind PI4 P and PI(4,5)P2 in vitro. Evidence was obtained that the other four members of the PATL family bound to EXO70A1 as well, and shared a similar localization pattern as PATL3.These findings offered new insights into exocyst subunitspecific function, and provided data and tools for further characterization of PATL family proteins. | Chengyun Wu Lu Tan Max van Hooren Xiaoyun Tan Feng Liu Yan Li Yanxue Zhao Bingxuan Li Qingchen Rui Teun Munnik Yiqun Bao | 2017 | Journal of Integrative Plant Biology2017，59，12： | 3 |
| 7 | Evolution of the R2R3-MYB gene family in six Rosaceae species and expression in woodland strawberry显示文摘R2R3-MYB gene family play important roles in plants development, metabolism, and responses to various biotic and abiotic stresses. In this study, 838 R2 R3-MYB genes were identified from six Rosaceae species, including 105 in woodland strawberry(Fragaria vesca), 173 in European pear(Pyrus communis), 219 in apple(Malus domestica), 121 in peach(Prunus persica), 121 in Chinese rose(Rosa chinensis), and 99 in black raspberry(Rubus occidentalis). All R2 R3-MYB genes in the six Rosaceae species were clustered into 51 species-specific duplicated clades with 109 genes and 50 lineage-specific duplicated clades with 242 genes according to phylogenetic analysis. R2 R3-MYB genes were distributed on all chromosomes in each of the six species, with a small amount of tandem duplication events. The proportion of tandem repeat genes ranged from 0 to 25.1%. The R2 R3-MYB protein was conserved in a clade and likely to share similar functions. The distribution of Ks showed the duplication times of R2 R3-MYB genes in six Rosaceae species. Furthermore, most of the R2 R3-MYB genes had Ka/Ks values less than 1, which indicated they were driven by purifying selection during the evolutionary processes. The GO term enrichment analysis revealed that R2 R3-MYB genes in strawberry and black raspberry were more divergent than in other Rosaceae species. Analysis of transcriptomes of 42 different tissues and development stages of woodland strawberry showed that high expression levels of R2 R3-MYB suggested that the R2 R3-MYB genes in strawberry played a key role in growth and development of both vegetative tissues and fruits. The strawberry R2 R3-MYB genes in sub-group of S1, S2, S11, S20, and S22 had high expression levels both in young leaves(YL) and old leaves(OL) strawberry tissues under drought treatments. | LIU Hui XIONG Jin-song JIANG Yue-ting WANG Li CHENG Zong-ming(Max) | 2019 | Journal of Integrative Agriculture2019，18，12： | 3 |
| 8 | Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction显示文摘While most patients with an anterior cruciate ligament(ACL) injury indicate satisfaction with surgical intervention, a significant proportion still do not return to pre-injury level of function or sport. Psychiatric comorbidities, such as depression, have recently been associated with poor clinical outcomes after ACL reconstruction(ACLR). To date, no article has yet examined how depression affects ACLR outcomes and how potential screening and intervention for psychological distress may affect postoperative activity level. The purpose of this review is to delineate potential relationships between depression and ACLR outcome, discuss clinical implications and identify future directions for research. | Hao-Hua Wu Max Liu Joshua S Dines John D Kelly Grant H Garcia | 2016 | World Journal of Orthopedics2016，7，11： | 2 |
| 9 | A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics显示文摘Rosa rugosa,commonly known as rugged rose,is a perennial ornamental shrub.It produces beautiful flowers with a mild fragrance and colorful seed pods.Unlike many other cultivated roses,R.rugosa adapts to a wide range of habitat types and harsh environmental conditions such as salinity,alkaline,shade,drought,high humidity,and frigid temperatures.Here,we produced and analyzed a high-quality genome sequence for R.rugosa to understand its ecology,floral characteristics and evolution.PacBio HiFi reads were initially used to construct the draft genome of R.rugosa,and then Hi-C sequencing was applied to assemble the contigs into 7 chromosomes.We obtained a 382.6Mb genome encoding 39,704 protein-coding genes.The genome of R.rugosa appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication(WGT),which occurred~100 million years ago in the ancestor of core eudicots.Based on a comparative analysis of the high-quality genome assembly of R.rugosa and other high-quality Rosaceae genomes,we found a unique large inverted segment in the Chinese rose R.chinensis and a retroposition in strawberry caused by post-WGT events.We also found that floral development-and stress response signaling-related gene modules were retained after the WGT.Two MADS-box genes involved in floral development and the stress-related transcription factors DREB2A-INTERACTING PROTEIN 2(DRIP2)and PEPTIDE TRANSPORTER 3(PTR3)were found to be positively selected in evolution,which may have contributed to the unique ability of this plant to adapt to harsh environments.In summary,the high-quality genome sequence of R.rugosa provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future. | Fei Chen Liyao Su Shuaiya Hu Jia-Yu Xue Hui Liu Guanhua Liu Yifan Jiang Jianke Du Yushan Qiao Yannan Fan Huan Liu Qi Yang Wenjie Lu Zhu-Qing Shao Jian Zhang Liangsheng Zhang Feng Chen Zong-Ming(Max)Cheng | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | Cancer stem cells: An old idea - A paradigm shift 显示文摘 | Max S Wicha Suling Liu Gabriela Dantu | | Cancer Res0，66，4： | 1 |
| 11 | The first genetic linkage map of Luohanguo (Siraitia grosvenorii) based on ISSR and SRAP markers显示文摘 | LIU L H MAX J WEI J H | 2011 | Genome2011，54，1： | 1 |
| 12 | Online Data-Driven Fuzzy Clustering With Applications to Real-Time Robotic Tracking 显示文摘 | Peter X Liu Max Q H Meng | 2004 | IEEE Transactions on Fuzzy Systems (S1063-6706)2004，12，4： | 1 |
| 13 | soja under NaC1 stress 显示文摘 | Luo Q Y Yu B J Liu Y L Differential sensitivity to chloride and sodium ions in seedlings of Glycine max and G | 2003 | Journal of Plant Physiology2003，16，： | 1 |
| 14 | Dynamic wheeled motion control of wheel-biped transformable robots显示文摘Most existing biped robots can only walk with their feet or move by wheels.To combine the best of both worlds,this paper introduces the dynamic wheeled control including wheeled locomotion and in-situ wheel-to-foot(WtF)transformation of a full-sized wheel-biped transformable robot SR600-II.It can traverse on flat surfaces by wheels and transform to footed stance through its switching modules when facing obstacles.For wheeled locomotion,the kinematics considering upper-body lumped center-of-mass(CoM)constraint is first derived.Then,the dynamics of wheeled locomotion is modeled as a wheeled inverted pendulum(WIP)with variables related to the pose of upper body.After that,a parameter-varying linear quadratic regulator(LQR)controller is utilized to enable dynamic wheeled locomotion.For WtF transformation,the WtF balance constraints are first revealed.Then,a WtF transformation strategy is proposed to tackle the problem when robot transforms from wheeled balance state to in-situ biped stance state.It enables the robot to pass by the transition stages in which both wheels and feet touch the ground and to maintain its balance at the same time.Simulations and experiments on the SR600-II prototype have validated the efficacy of proposed dynamic wheeled control strategies for both wheeled locomotion and in-situ WtF transformation. | Chao Zhang Tangyou Liu Shuang Song Jiaole Wang Max Q-H.Meng | 2022 | Biomimetic Intelligence & Robotics2022，2，2： | 1 |
| 15 | Growth of carbon nanotube arrays using the existing array as a substrate and their Raman characterization显示文摘 | SUN L F LIU Z Q MAX C | 2001 | Chemical Physics Letters2001，340，： | 1 |
| 16 | Triterpenoid sap- onins from the roots of Clematis chinensis Osbeck 显示文摘 | LIU L F MAX L WANG Y X | 2009 | Journal of Asian Natural Products Research2009，11，5： | 1 |
| 17 | Preparation of a high strength A1-Cu-Mg alloy by mechanical alloying and press-forming 显示文摘 | TANG H CHENG Z LIU J MAX | 2006 | Materials Science and Engineering A2006，550，： | 1 |
| 18 | CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts显示文摘 | Ginestier Christophe Liu Suling Diebel Mark E Korkaya Hasan Luo Ming Brown Marty Wicinski Julien Cabaud Olivier Charafe-Jauffret Emmanuelle Birnbaum Daniel Guan Jun-Lin Dontu Gabriela Wicha Max S | 2010 | Journal of Clinical Investigation2010，，2： | 1 |
| 19 | Nutrient cycling and distribution in different-aged plantation of Chinese fir in southeast China 显示文摘 | MAX Q HEAL K V LIU A | 2007 | Forest Ecology and Management2007，243，： | 1 |
| 20 | soja under NaCl Stress 显示文摘 | Luo Q Y Yu B J Liu Y L Differential Sensitivity to Chloride and Sodium Ions in Seedlings of Glycine max and G | 2005 | Journal of Plant Physiology2005，162，： | 1 |
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