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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | 应用可扩展的套索回归模型对间皮瘤进行生存期预测:临床预测指标的使用和初始性能的说明显示文摘目的对恶性胸膜间皮瘤(MPM)进行准确的预后预测具有一定困难。我们研究一套健全的计算模型来量化常规可用临床数据的预后价值,它们构成了已发布的MPM预测模型的基础。 | 王臻(译) 施焕中(校) Andrew C Kidd Michael McGettrick Selina Tsim Daniel L Halligan Max Bylesjo Kevin G Blyth | 2018 | 英国医学杂志中文版2018，21，6： | 11 |
| 3 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 4 | Activation mechanism for sacrificial Al/Zn/Hg anodes显示文摘 | Max C Reboul Marc C Delatte | 1980 | Materials Performance1980，19，5： | 1 |
| 5 | Expression of CD4 on Epstein-Barr virus-immortalized B cells显示文摘 | Hoennscheidt C Max D Richter N | 2009 | Scand J lmmunol2009，70，3： | 1 |
| 6 | Infrared spectra of aquous ionic salt mixtures at low concentrations: Ion pairing in water 显示文摘 | Max J J Chapados C | 2007 | The Journal of Chem Phys2007，127，11： | 1 |
| 7 | 显示文摘 | Zhao X S Lu Max G Q Song C | 2003 | J Mol Catal A:Chem2003，191，： | 1 |
| 8 | Origin of sulphur and geothermometry of hydrothermal sulphides from the Galapagos Rift, 86^oW显示文摘 | Russell S Max L C | 1982 | Nature1982，299，： | 1 |
| 9 | Effect of hospital volume, surgeon experience, and surgeon volume on pa- tient outcomes after pancreaticoduodenectomy 显示文摘 | Max Schmidt C Olivier Tun'ini Purvi Parikh | 2010 | Arch Surg2010，145，7： | 1 |
| 10 | A new approach to deep desulfurization of gasoline, diesel fuel and jet fuel by selective adsorption for ultra-clean fuels and for fuel cell applications显示文摘 | MAX L SUN L SONG C S | 2002 | Catal Today2002，77，12： | 1 |
| 11 | External control of anthocyanin formation in apple 显示文摘 | Max C | 1990 | Scientia Horticulture1990，42，： | 1 |
| 12 | A new approach to deepdesulfur ization of gasoline, diesel fuel and jet fuel by selective adsorp tion for ultra-clean fuels and for cell applications显示文摘 | MAX L SUN L SONG C S | 2002 | Catalysis Today2002，77，： | 1 |
| 13 | A microplate flurimetric assay for the study of enzyme diversity in soils 显示文摘 | Max C Wood M Jarvis S C | 2001 | Soil Biology & Bioche- mistry2001，，33： | 1 |
| 14 | Self-modulation and self-focusing of electromagnetic waves in plasmas显示文摘 | Aron J Langdon A B | 1974 | Phys Rev Lett1974，33，： | 1 |
| 15 | Effect of ultrasound on the structural and physiochemical properties of organosolv soluble hemicelluloses from wheat straw显示文摘 | SUN R C SUN X F MAX H | 2002 | Ultrason Sonochem2002，9，2： | 1 |
| 16 | A joint locationinventory model显示文摘 | Max S Coullard C Daskin M S | 2003 | Transportation Science2003，37，1： | 1 |
| 17 | A stakeholder framework for analyzing and evaluating corporate social performance 显示文摘 | Max B E C | 1995 | Academy of Management Review1995，，20： | 1 |
| 18 | Hypoxia inducible factor-1(HIF-1)显示文摘 | Qingdong K Max C | 2006 | MolPharmaco2006，70，5： | 1 |
| 19 | Growth of carbon nanotube arrays using the existing array as a substrate and their Raman characterization显示文摘 | SUN L F LIU Z Q MAX C | 2001 | Chemical Physics Letters2001，340，： | 1 |
| 20 | Effects of preharvest bagging on fruit quality and postharvest physiology of pears (Pyrus communis) 显示文摘 | AMARANTE C BANKS N H MAX S | 2002 | New Zeal J Crop Hort Sci2002，30，2： | 1 |
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