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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Direct coronary vasodilator action of adrenomedullin is mediated by nitric oxide显示文摘 | De MATTEO R MAY C N | 2003 | Br J Pharmacol2003，140，8： | 2 |
| 3 | New NDT techniques for the assessment offire-damaged concrete structures显示文摘 | Matteo C Roberto F | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 4 | Laparoscopic management of ovar- ian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 5 | Laparoscopic management of ovarian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 6 | The orbital glands of the terrapin Pseudemys scripta in response to osmotic stress:a light and electron microscope study显示文摘 | Baccari G C Minucci S Di Matteo L | 1993 | J Anat1993，183，1： | 1 |
| 7 | Four channel, 40 ps resolution, fully integrated time-to-amplitude converter for time-resolved photon counting 显示文摘 | Matteo C Ivan R Massimo G | 2012 | IEEE Journal of Solid-State Circuits2012，47，3： | 1 |
| 8 | Biochemical evidence that tire atypical antipsychotic drags dozapine and rispenlone block 5-HT (2C) receptors in vivo显示文摘 | Di Matteo V Cacchio M Di Giulio C | 2002 | Phannacol Biochem Behav2002，71，4： | 1 |
| 9 | Laparoscopic management of ovarian cysts in newborns显示文摘 | Esposito C Garipoli V Matteo GD | 1998 | Surg Endosc1998，12，9： | 1 |
| 10 | Screen Printed Biosensors for Detection of Nitrates in Drinking Water 显示文摘 | Albanese D Matteo D M Alessio C | 2010 | Computer Aided Chemical Engineering2010，28，： | 1 |
| 11 | Assessment and treatment of elderly patients with cancer 显示文摘 | Lodovico B Giuseppe C Matteo C | 2010 | Surgical Oncology2010，19，： | 1 |
| 12 | The crystal structure of PGIP (polygalacturonase-inhibiting protein), a leucine-rich repeat protein involved in plant defense 显示文摘 | Di Matteo A Federici L Mattei B Salvi G Johnson K A Savino C DeLorenzo G Tsernoglou D Cervone F | 2003 | Proc Natl Acad Sci2003，100，10： | 1 |
| 13 | Knowledge and attitudesabout cancer pain management : A national survey of Italian on-cologY nurses 显示文摘 | Matteo B Gianluca C Annie L et (27 | 2007 | European Journal of Oncology Nursing2007，11，： | 1 |
| 14 | Conditional Survival after Hepatic Resection for Hepatocellular Carcinoma in Cirrhotic Pa- tients显示文摘 | Alessandro C Fabio P Matteo C | 2012 | Clin Cancer Res2012，18，16： | 1 |
| 15 | Fast Determination of Catechins and Xanthines in Tea Beverages by Micellar Electrokinetic Chromatography显示文摘 | Matteo B Piero C Marco P | 2003 | J Agric Food Chem2003，51，： | 1 |
| 16 | Collecting Exhaled Breath Condensate (EBC)with Two Condensers in Series: A Promising Technique for Studying the Mechanisms of EBC Formation, and the Volatility of Selected Biomarkers 显示文摘 | Massimo C Matteo G Andrea C | 2008 | Journal of Aerosol Medicine and Pulmonary Drug Delivery2008，21，1： | 1 |
| 17 | Aerobic submerged fermen- tation by acetic acid bacteria for vinegar production: Process and biotechnological aspects 显示文摘 | Maria G Elena V Matteo C | 2014 | Process Biochemistry2014，49，10： | 1 |
| 18 | Determination of hexavalent chromilxm in exhaled breath condensate and environmental air among chrome plating workers 显示文摘 | Matteo G Andrea C Diana P | 2006 | Analytica Chimiea Acta2006，562，： | 1 |
| 19 | Generation of optimal trajectories for earth hybrid pole sitters 显示文摘 | MATTEO C MCINNES C R | 2011 | Journal of Guidance Control and Dynamics2011，34，3： | 1 |
| 20 | Knowledge and attitudes about cancer pain management:A national survey of Italian oncology nurses显示文摘 | Matteo B Gianluca C Annie L | 2007 | European Journal of Oncology Nursing2007，11，： | 1 |
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