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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies显示文摘Spondyloarthropathies(SpA) are commonly observed extra-intestinal manifestations of both Crohn's disease(CD) and ulcerative colitis(UC), the two major forms of inflammatory bowel diseases(IBD).However, the immunological link between these two clinical entities is still poorly understood.Several lines of evidence indicate that SpA may originate from the relocation to the joints of the immune process primarily induced in the gut.The transfer of the intestinal inflammatory process into the joints implicates that immune cells activated in the gut-draining lymph nodes can localize, at a certain point of the intestinal disease, either into the gut or into the joints.This is indicated by the over-lapping expression of adhesion molecules observed on the surface of intestinal and synovial endothelial cells during inflammation.Moreover bacterial antigens and HLA-B27 expression may be implicated in the reactivation of T cells at the articular level.Finally, accumulating evidence indicates that a T helper 17 cell-mediated immune response may contribute to IBD and IBD-related SpA with a crucial role played by tumor necrosis factor-α in CD and to a lesser extent in UC. | Massimo C Fantini Francesco Pallone Giovanni Monteleone | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 3 | Thermodynamical and structural properties of fcc transition metals using a simple tight-binding model显示文摘 | Rosato V Massimo C Legrand B | 1989 | Philos Mag A1989，59，2： | 1 |
| 4 | Vehicle Yaw Control via Second-Order Sliding-Mode Technique显示文摘 | Massimo C Lorenzo F Antonella F | 2008 | IEEE Transactions on Industrial Electronics2008，55，11： | 1 |
| 5 | Potential of unicellular cyanobacteria from saline environments as exopolysaccharide producers 显示文摘 | MARIA C M RICCARDO M MASSIMO V | 1998 | Applied and Environment Microbiology1998，64，3： | 1 |
| 6 | Next-Generation Access Network: A Wireless Network Using E-Band Radio Frequency (71 - 86GHz) to Provide Wideband Connectivity 显示文摘 | Claudio C Massimo C | 2011 | Bell Labs Technical Journal2011，16，1： | 1 |
| 7 | Thermal oxidative degrada-tion of AES显示文摘 | Oscar C Marino G Massimo L | 1995 | Polymer Degradation and Stability1995，47，： | 1 |
| 8 | Recombinant human, active site-blocked factor Ⅶa reduces infarct size and no-reflow phenomenon in rabbits显示文摘 | Paolo G Massimo R Plinio C | 2000 | Am J Physiol Heart Circ Physiol2000，278，： | 1 |
| 9 | Late complete artriovenous block af- ter percutaneous closure of a perimembranous ventricular septal de- fect 显示文摘 | Butera G Massimo C Mario C | 2006 | Catheter Cardiovasc Interv2006，67，6： | 1 |
| 10 | Multi-echelon, multi-in- denture spare parts inventory control subject to system availabili- ty and budget constraints显示文摘 | Francesco C Giulio D G Massimo T | 2013 | Reliability Engineering & System Safety2013，119，11： | 1 |
| 11 | Lung Recruitment in patients with the acute respiratory distress syndrome显示文摘 | Luciano L Pietro C Massimo C | 2006 | N Engl J Med2006，354，17： | 1 |
| 12 | Four channel, 40 ps resolution, fully integrated time-to-amplitude converter for time-resolved photon counting 显示文摘 | Matteo C Ivan R Massimo G | 2012 | IEEE Journal of Solid-State Circuits2012，47，3： | 1 |
| 13 | Artificial neural networks in process estimation and control显示文摘 | Willis M J Montague G A Di Massimo C | 1992 | Automatica1992，28，6： | 1 |
| 14 | Soil genotoxicity sssessment: A new strategy based on biomolecular tools and plant bioindicators 显示文摘 | Sandra C Roberta A Massimo L | 2002 | Environ Sci Technol2002，36，： | 1 |
| 15 | The brachytic2 and 3 maize double mutant shows alterations in plant growth and embryo development 显示文摘 | Elena C Daniele V Massimo D | 2011 | Plant Growth Regul2011，64，： | 1 |
| 16 | Early and late complications associated with transcatheter occlusion of secundumatrial septal defect显示文摘 | Massimo C Mario C Gianfranco B | 2002 | JACC2002，39，6： | 1 |
| 17 | Towards improved penicillin fermentation via artificial neural networks显示文摘 | Massimo C D | 1994 | Computers Chem Eng1994，18，4： | 1 |
| 18 | Systemic absorption and pharmacokinetics of single-dose early intravesical mitomycin C after transurethral resection of non-muscle-invasive bladder cancer显示文摘 | Massimo M Fabio C Egi EM | | 0，，： | 1 |
| 19 | Synthesis and optical characterization of new highly luminescent poly(m,p-phenylenevinylene)derivatives显示文摘 | Gabriele G Massimo C Piergiulio D M | 2001 | Synth Met2001，123，： | 1 |
| 20 | Cerebral amyloid angiopathy presenting as nonhemorrhagic diffuse encephalopathy:neuropathologic and neuroradiologic manifestations in one case显示文摘 | Massimo C Donatella T Roland B | 2001 | Am J Neuroradiol2001，22，： | 1 |
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