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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Performant implementation of the atomic cluster expansion(PACE)and application to copper and silicon显示文摘The atomic cluster expansion is a general polynomial expansion of the atomic energy in multi-atom basis functions.Here we implement the atomic cluster expansion in the performant C++code PACE that is suitable for use in large-scale atomistic simulations.We briefly review the atomic cluster expansion and give detailed expressions for energies and forces as well as efficient algorithms for their evaluation.We demonstrate that the atomic cluster expansion as implemented in PACE shifts a previously established Pareto front for machine learning interatomic potentials toward faster and more accurate calculations.Moreover,general purpose parameterizations are presented for copper and silicon and evaluated in detail.We show that the Cu and Si potentials significantly improve on the best available potentials for highly accurate large-scale atomistic simulations. | Yury Lysogorskiy Cas van der Oord Anton Bochkarev Sarath Menon Matteo Rinaldi Thomas Hammerschmidt Matous Mrovec Aidan Thompson Gábor Csányi Christoph Ortner Ralf Drautz | 2021 | npj Computational Materials2021，，1： | 3 |
| 3 | Laparoscopic management of ovar- ian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 4 | Would you mind if I get more? An experimental study of the envy game显示文摘 | Sandro Casal Werner Güth Mofei Jia Matteo Ploner | 2012 | Journal of Economic Behavior and Organization2012，，3： | 1 |
| 5 | Detection and quanti- fication of airborne conidia of Fusarium circinatum, the causal agent of pine pitch canker, from two California sites by using a real - time PCR approach combined with a simple spore trapping method 显示文摘 | Wolfgang S Kerry 0 D Matteo G | 2004 | App Envir Micro2004，70，63： | 1 |
| 6 | Validation of an antbsphingosine-l-phos- phate antibody as a potential therapeutic in reducing growth, invasion,and angiogenesis in multiple tumor lineages显示文摘 | Visentin B Vekich J A Sibbald B J Cavalli A L Moreno K M Matteo R G | 2006 | Canc- er Cell2006，9，： | 1 |
| 7 | Laparoscopic management of ovarian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 8 | Calcipotriol and betamethasone dipropionate in the treatment of mild-to- moderate psoriasis: a cost effectiveness analysis of the ointment versus gel formulation ]显示文摘 | Colombo GL Matteo SD Bruno G | 2012 | Clinieoeeon Out- comes Res2012，21，4： | 1 |
| 9 | The orbital glands of the terrapin Pseudemys scripta in response to osmotic stress:a light and electron microscope study显示文摘 | Baccari G C Minucci S Di Matteo L | 1993 | J Anat1993，183，1： | 1 |
| 10 | Relation between renal function within the normal range and central and peripheral arterial stiffness in hypertension显示文摘 | Schillaci G Matteo P Massimo R | 2006 | Hypertension2006，48，4： | 1 |
| 11 | Four channel, 40 ps resolution, fully integrated time-to-amplitude converter for time-resolved photon counting 显示文摘 | Matteo C Ivan R Massimo G | 2012 | IEEE Journal of Solid-State Circuits2012，47，3： | 1 |
| 12 | Intraoperative effects of combined versus general anesthesia during major liver surgery 显示文摘 | Siniscalchi A Begliomini B Matteo G | 2003 | Minerva Anestesiol2003，69，12： | 1 |
| 13 | Three-mode entanglement by interlinked nonlinear interactions in optical media显示文摘 | Ferraro Matteo A Patls G A Maria Bondani | 2004 | J Opt Soc Am B2004，21，： | 1 |
| 14 | Detection of toxigenic strains of Fusarium vertieil- lioides in corn by electronic olfactory system显示文摘 | Matteo Falascon I Emanuela G Obb I Matteo Pardo | 2005 | Sensors and Actuators B: Chemical2005，108，12： | 1 |
| 15 | Increased C-reactive protein concentrations in never-treated hypertension: the role of systolic and pulse pressures显示文摘 | GIUSEPPE S MATTEO P FABIO G | 2003 | J Hypertension2003，21，10： | 1 |
| 16 | Intake of tomato-en- riched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons 显示文摘 | di Matteo V Pierucci M Di Giovanni G | 2009 | J Neural Transmission2009，73，： | 1 |
| 17 | Analysis of green tea catechins: comparative study between HPLC and HPCE显示文摘 | MATTEO B MARCO P TULLIA G Y | 2003 | Food Chemistry2003，81，4： | 1 |
| 18 | Dete- ction of toxigenic strains of fusarium verticil- lioides in corn by electronic olfactory system 显示文摘 | Matteo F Emanuela G Matteo P | 2005 | Sensors and Actuators B: Chemical2005，108，2： | 1 |
| 19 | Insight into B cell development and differentiation显示文摘 | Moschese V Orlandi P Di Matteo G | 2004 | Acta Paediatr Suppl2004，93，445： | 1 |
| 20 | The crystal structure of PGIP (polygalacturonase-inhibiting protein), a leucine-rich repeat protein involved in plant defense 显示文摘 | Di Matteo A Federici L Mattei B Salvi G Johnson K A Savino C DeLorenzo G Tsernoglou D Cervone F | 2003 | Proc Natl Acad Sci2003，100，10： | 1 |
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